ChemicalBook > CAS DataBase List > GW4869
GW4869
- Product Name
- GW4869
- CAS No.
- 6823-69-4
- Chemical Name
- GW4869
- Synonyms
- GW 4869 (hydrochloride hydrate);CS-2410;GW4869(2);GW4869(1);GW4869 HCl;GW4869 2HCl;GW4869/GW-4869;GW4869 (GW69A);GW69A， GW554869A;GW4869 USP/EP/BP
- CBNumber
- CB4972736
- Molecular Formula
- C30H29ClN6O2
- Formula Weight
- 541.05
- MOL File
- 6823-69-4.mol
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GW4869 Property
- Melting point:
- >300 °C
- storage temp.
- 2-8°C
- solubility
- DMSO: soluble0.2mg/mL
- form
- powder
- color
- light yellow to yellow
- InChIKey
- NSFKAZDTKIKLKT-LOLTXFFGSA-N
- SMILES
- Cl.Cl.O=C(Nc1ccc(cc1)C2=NCCN2)\C=C/c3ccc(\C=C/C(=O)Nc4ccc(cc4)C5=NCCN5)cc3
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Safety
- Safety Statements
- 22-24/25
- WGK Germany
- 3
- HS Code
- 2933299090
- Storage Class
- 11 - Combustible Solids
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- D1692
- Product name
- GW4869
- Purity
- ≥90% (NMR)
- Packaging
- 5mg
- Price
- $243
- Updated
- 2025/07/31
Cayman Chemical
- Product number
- 13127
- Product name
- GW 4869 (hydrochloride hydrate)
- Purity
- ≥90%
- Packaging
- 500μg
- Price
- $33
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 13127
- Product name
- GW 4869 (hydrochloride hydrate)
- Purity
- ≥90%
- Packaging
- 1mg
- Price
- $62
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- D1692
- Product name
- GW4869
- Purity
- ≥90% (NMR)
- Packaging
- 25mg
- Price
- $919
- Updated
- 2025/07/31
Cayman Chemical
- Product number
- 13127
- Product name
- GW 4869 (hydrochloride hydrate)
- Purity
- ≥90%
- Packaging
- 5mg
- Price
- $160
- Updated
- 2024/03/01
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GW4869 Chemical Properties,Usage,Production
Uses
GW4869 has been used:
- as an inhibitor of neutral sphingomyelinase and exosome biogenesis
- to analyse the effects of arsenic trioxide (ATO) treatment for hepatoma carcinoma HCCLM3 cells on ceramide production
- to determine the contributions of p75 neurotrophin receptor (p75NTR) and tropomyosin receptor kinase A (TrkA)- coupled pathways to nerve growth factor (NGF)-induced thermal hypersensitivity in rats
General Description
GW4869 is a commonly used pharmacological agent, which inhibits exosome generation. It blocks ceramide-mediated inward budding of multivesicular bodies (MVBs) and the release of mature exosomes from MVBs. GW4869 exhibits cytotoxicity to phosphatidylserine-expressing myeloma cells. It inhibits the secretion of IFN (interferon)-α by plasmacytoid dendritic cells?(pDCs).
Biochem/physiol Actions
A cell-permeable, potent, specific, non-competitive inhibitor of N-SMase (neutral sphingomyelinase)
in vivo
GW4869 (2.5 μg/g, i.p.) causes inhibition of exosome release blocks LPS-stimulated pro-inflammatory cytokine production and cardiac inflammation in mice. GW4869 mitigates LPS-caused myocardial dysfunction and improves survival in mice[2].
GW4869 (2.5 μg/g, i.p.) blocks the production of pro-inflammatory cytokines and cardiac inflammation in CLP mice[2].
| Animal Model: | 10-12 weeks old Male wild-type C57BL/6 mice (Endotoxin-Challenged Mice)[2]. |
| Dosage: | 2.5 μg/g. |
| Administration: | I.P. once (1 h later, followed by an i.p. injection of LPS (2.5 μg/g, 100 μL)). |
| Result: | Significantly decreased exosome levels by 37% in sera, compared to levels collected from control mice. At 12 h after LPS injection, the levels of circulating exosomes were increased significantly compared to PBS-controls, as evidenced by a 1.7-fold elevation in the AChE activity. |
| Animal Model: | 10-12 weeks old Male wild-type C57BL/6 mice (CLP Polymicrobial Sepsis Model)[2]. |
| Dosage: | 2.5 μg/g. |
| Administration: | I.P. once (before sham or CLP surgery). |
| Result: | Decreased exosome concentration by 33% compared to mice injected with PBS in sham-surgery controls. CLP-stimulated exosome release was significantly inhibited by pre-treatment of CLP mice compared to CLP mice pre-treated with PBS. |
GW4869 Preparation Products And Raw materials
Raw materials
Preparation Products
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GW4869 Suppliers
- Tel
- 0330-2528181
- Fax
- 0330-2528171
- sales@vdmbio.com
- Country
- United States
- ProdList
- 510
- Advantage
- 64
- Tel
- 0411-62910999 13889544652
- sales@meilune.com
- Country
- China
- ProdList
- 4759
- Advantage
- 58
- Tel
- 021-58955995
- Fax
- 609-228-5909
- sales@medchemexpress.cn
- Country
- United States
- ProdList
- 4861
- Advantage
- 58
- Tel
- 020-39119399 18927568969
- Fax
- 020-39119999
- isunpharm@qq.com
- Country
- China
- ProdList
- 4720
- Advantage
- 55
- Tel
- +1 (866) 930-6790
- Fax
- +1 (866) 333-9607
- info@adooq.com
- Country
- United States
- ProdList
- 2782
- Advantage
- 58
- Tel
- 400-400-164-7117 18317119277
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 40000
- Advantage
- 60
- Tel
- 15221275939
- Fax
- 021-50706099
- shenlinxing@macklin.cn
- Country
- China
- ProdList
- 15872
- Advantage
- 55
- Tel
- 025-58849295 18951903616;
- Fax
- 025-68650336
- info@adooq.cn
- Country
- China
- ProdList
- 2990
- Advantage
- 60
- Tel
- 021-61415566 800-8193336
- orderCN@merckgroup.com
- Country
- China
- ProdList
- 51395
- Advantage
- 80
- Tel
- 021-52996696，15000506266 15000506266
- Fax
- +86-21-52996696
- Country
- China
- ProdList
- 4797
- Advantage
- 55
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View Lastest Price from GW4869 manufacturers
Dideu Industries Group Limited
- Product
- GW4869 6823-69-4
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons min
- Release date
- 2021-08-17
Career Henan Chemical Co
- Product
- GW4869 6823-69-4
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99.99%
- Supply Ability
- 200kg
- Release date
- 2019-12-20