ChemicalBook > CAS DataBase List > GW4869

GW4869

Product Name
GW4869
CAS No.
6823-69-4
Chemical Name
GW4869
Synonyms
GW 4869 (hydrochloride hydrate);CS-2410;GW4869(2);GW4869(1);GW4869 HCl;GW4869 2HCl;GW4869/GW-4869;GW69A， GW554869A;GW4869 USP/EP/BP;N-SMase Inhibitor
CBNumber
CB4972736
Molecular Formula
C30H29ClN6O2
Formula Weight
541.05
MOL File
6823-69-4.mol
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GW4869 Property

Melting point:
>300 °C
storage temp. 
2-8°C
solubility 
DMSO: soluble0.2mg/mL
form 
powder
color 
light yellow to yellow
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
HS Code 
2933299090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
D1692
Product name
GW4869
Purity
≥90% (NMR)
Packaging
5mg
Price
$236
Updated
2024/03/01
Cayman Chemical
Product number
13127
Product name
GW 4869 (hydrochloride hydrate)
Purity
≥90%
Packaging
500μg
Price
$33
Updated
2024/03/01
Cayman Chemical
Product number
13127
Product name
GW 4869 (hydrochloride hydrate)
Purity
≥90%
Packaging
1mg
Price
$62
Updated
2024/03/01
Sigma-Aldrich
Product number
D1692
Product name
GW4869
Purity
≥90% (NMR)
Packaging
25mg
Price
$851
Updated
2024/03/01
Cayman Chemical
Product number
13127
Product name
GW 4869 (hydrochloride hydrate)
Purity
≥90%
Packaging
5mg
Price
$160
Updated
2024/03/01
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GW4869 Chemical Properties,Usage,Production

Uses

GW4869 has been used:

  • as an inhibitor of neutral sphingomyelinase and exosome biogenesis
  • to analyse the effects of arsenic trioxide (ATO) treatment for hepatoma carcinoma HCCLM3 cells on ceramide production
  • to determine the contributions of p75 neurotrophin receptor (p75NTR) and tropomyosin receptor kinase A (TrkA)- coupled pathways to nerve growth factor (NGF)-induced thermal hypersensitivity in rats

General Description

GW4869 is a commonly used pharmacological agent, which inhibits exosome generation. It blocks ceramide-mediated inward budding of multivesicular bodies (MVBs) and the release of mature exosomes from MVBs. GW4869 exhibits cytotoxicity to phosphatidylserine-expressing myeloma cells. It inhibits the secretion of IFN (interferon)-α by plasmacytoid dendritic cells?(pDCs).

Biochem/physiol Actions

A cell-permeable, potent, specific, non-competitive inhibitor of N-SMase (neutral sphingomyelinase)

GW4869 Preparation Products And Raw materials

Raw materials

Preparation Products

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GW4869 Suppliers

China 68 India 2 Switzerland 1 United States 15 Global 86
VDM Biochemicals
Tel
0330-2528181
Fax
0330-2528171
Email
sales@vdmbio.com
Country
United States
ProdList
510
Advantage
64
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
meilunui@163.com
Country
China
ProdList
4727
Advantage
58
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
Guangzhou Isun Pharmaceutical Co., Ltd
Tel
020-39119399 18927568969
Fax
020-39119999
Email
isunpharm@qq.com
Country
China
ProdList
4428
Advantage
55
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
Country
United States
ProdList
2782
Advantage
58
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
41462
Advantage
60
Shanghai Macklin Biochemical Co.,Ltd.
Tel
15221275939 15221275939
Fax
021-50706099
Email
shenlinxing@macklin.cn
Country
China
ProdList
16166
Advantage
55
AdooQ Bioscience CHINA
Tel
025-58849295 18951903616;
Fax
025-68650336
Email
info@adooq.cn
Country
China
ProdList
2990
Advantage
60
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51456
Advantage
80
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4512
Advantage
55
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View Lastest Price from GW4869 manufacturers

Dideu Industries Group Limited
Product
GW4869 6823-69-4
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons min
Release date
2021-08-17
Career Henan Chemical Co
Product
GW4869 6823-69-4
Price
US $1.00/g
Min. Order
1g
Purity
99.99%
Supply Ability
200kg
Release date
2019-12-20

6823-69-4, GW4869Related Search:


  • N-SMase Inhibitor, GW4869 - CAS 6823-69-4 - Calbiochem
  • CS-2410
  • N-SMase Inhibitor
  • 2-PropenaMide, 3,3'-(1,4-phenylene)bis[N-[4-(4,5-dihydro-1H-iMidazol-2-yl)phenyl]-, hydrochloride (1:2)
  • 4',4''-Di-2-imidazolin-2-yl-p-benzenediacrylanilide dihydrochloride
  • GW 4869 (hydrochloride hydrate)
  • GW4869/GW-4869
  • GW4869 dihydrochloride
  • GW4869;GW 4869 HYDROCHLORIDE HYDRATE
  • GW4869(1)
  • GW4869(2)
  • GW69A， GW554869A
  • GW4869 USP/EP/BP
  • GW4869 2HCl
  • p-Benzenediacrylanilide, 4′,4′′-di-2-imidazolin-2-yl-, dihydrochloride
  • GW4869 HCl
  • GW-4869,Inhibitor,Phospholipase,GW4869,inhibit
  • 6823-69-4
  • C30H28N6O22HCl
  • C30H30N6Cl2O2
  • API
  • A cell-permeable, symmetrical dihydroimidazolo-amide compound that acts as a potent, specific, non-competitive inhibitor of N-SMase.