Description Physical properties
ChemicalBook > CAS DataBase List > N-(4-CYANO-PHENYL)-GLYCINE

N-(4-CYANO-PHENYL)-GLYCINE

Description Physical properties
Product Name
N-(4-CYANO-PHENYL)-GLYCINE
CAS No.
42288-26-6
Chemical Name
N-(4-CYANO-PHENYL)-GLYCINE
Synonyms
N-(4-Cyanophenyl)glycine(DG10);4-Cyano phenyl Glycine;N-(p-Cyanophenyl)glycine;N-(4-Cynophenyl)-Glycine;Dabigatran Intermediate 2;N-(4-CYANO-PHENYL)-GLYCIN;N-(4-CYANO-PHENYL)-GLYCINE;Glycine, N-(4-cyanophenyl)-;N-(4-Cyanophenyl)glycine >N-(4-Cyanophenyl)glycine, 98%
CBNumber
CB51011398
Molecular Formula
C9H8N2O2
Formula Weight
176.17
MOL File
42288-26-6.mol
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N-(4-CYANO-PHENYL)-GLYCINE Property

Melting point:
237 °C(dec.)
Boiling point:
447.2±30.0 °C(Predicted)
Density 
1.30±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
Dichloromethane (Slightly), DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
3.81±0.10(Predicted)
color 
White to Pale Yellow
InChI
InChI=1S/C9H8N2O2/c10-5-7-1-3-8(4-2-7)11-6-9(12)13/h1-4,11H,6H2,(H,12,13)
InChIKey
KJRQMXRCZULRHF-UHFFFAOYSA-N
SMILES
C(O)(=O)CNC1=CC=C(C#N)C=C1
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Safety

HS Code 
2926907090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical
Product number
C2771
Product name
N-(4-Cyanophenyl)glycine
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$30
Updated
2025/07/31
TCI Chemical
Product number
C2771
Product name
N-(4-Cyanophenyl)glycine
Purity
>98.0%(HPLC)(T)
Packaging
25g
Price
$87
Updated
2025/07/31
TRC
Product number
C982125
Product name
N-(4-Cyanophenyl)-glycine
Packaging
5G
Price
$90
Updated
2021/12/16
AK Scientific
Product number
X1037
Product name
N-(4-Cyanophenyl)glycine
Packaging
1g
Price
$14
Updated
2021/12/16
AK Scientific
Product number
X1037
Product name
N-(4-Cyanophenyl)glycine
Packaging
5g
Price
$17
Updated
2021/12/16
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N-(4-CYANO-PHENYL)-GLYCINE Chemical Properties,Usage,Production

Description

Dabigatran etexilate is a novel synthetic direct thrombin inhibitor, a prodrug of dabigatran, a non-peptide thrombin inhibitor. Dabigatran etexilate intermediate II is an impurity produced during the preparation of dabigatran etexilate.

Physical properties

N-(4-Cyanophenyl)glycine is a off-white Solid.

Uses

Dabigatran etexilate intermediate

Uses

N-(4-Cyanophenyl)-glycine (cas# 42288-26-6) is a compound useful in organic synthesis.

Synthesis

79-08-3

873-74-5

42288-26-6

3.2.3 Preparation of [(4-cyanophenyl)amino]acetic acid (V). Molecular formula: C9H8N2O2. molecular weight: 176.17. Raw materials: 90g (0.75mol) of bromoacetic acid (F), 211.7g (1.5mol) of p-aminobenzonitrile (G), 35g (0.42mol) of sodium bicarbonate. Procedure: bromoacetic acid (F) and p-aminobenzonitrile (G) were mixed in 1250 ml of water to form a suspension. The suspension was placed in a bath heated to 100-110°C for 3 hours. Upon completion of the reaction, the reaction vessel was removed from the bath and cooled to room temperature, followed by further cooling in a refrigerator. The precipitate was separated by diafiltration and dried in a vacuum desiccator at 100 °C. Yield of crude product: 122 g (92.8% yield), HPLC purity: 97%. Purification step: the crude product was converted to sodium salt and re-acidified using aqueous sodium bicarbonate to release the free acid by dilute hydrochloric acid (1:1). After filtration, the product was washed with water and dried in a vacuum desiccator at 105°C. The product was then purified to a sodium salt using aqueous sodium bicarbonate. Yield of purified product: 115 g (88% yield), HPLC purity: 99.1%, water content: 0.13%, sulfated ash: 1.8%.

References

[1] Patent: WO2009/111997, 2009, A1. Location in patent: Page/Page column 11
[2] Patent: WO2013/111163, 2013, A2. Location in patent: Page/Page column 18
[3] Patent: US2015/11589, 2015, A1. Location in patent: Paragraph 0121-0122
[4] European Journal of Medicinal Chemistry, 2016, vol. 120, p. 148 - 159

N-(4-CYANO-PHENYL)-GLYCINE Preparation Products And Raw materials

Raw materials

Preparation Products

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N-(4-CYANO-PHENYL)-GLYCINE Suppliers

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View Lastest Price from N-(4-CYANO-PHENYL)-GLYCINE manufacturers

Anhuyan (Hainan) Biotechnology Co., LTD
Product
N-(4-CYANO-PHENYL)-GLYCINE 42288-26-6
Price
US $0.00-0.00/KG
Min. Order
0.001KG
Purity
99.99%
Supply Ability
200000KG
Release date
2025-06-16
WUHAN FORTUNA CHEMICAL CO., LTD
Product
N-(4-Cyanophenyl)glycine 42288-26-6
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
99%min
Supply Ability
1000kg
Release date
2021-10-29
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
Product
N-(4-CYANO-PHENYL)-GLYCINE 42288-26-6
Price
US $100.00-75.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000
Release date
2024-08-14

42288-26-6, N-(4-CYANO-PHENYL)-GLYCINERelated Search:

3-(S)-(+)-(1-Carbamoyl-1,1-diphenylmethyl)pyrroloidine-L-(+)-tartarate HEXYL CHLOROFORMATE N-[[2-[[[4-(Aminoiminomethyl)phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-(2-pyridinyl)-beta-alanine ethyl ester hydrochloride 4-Aminobenzamidine dihydrochloride 3-[[[2-[[(4-Cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]pyridin-2-ylamino]propionic acid ethyl ester ETHYL N-[4-(METHYLAMINO)-3-NITROBENZOYL]-N-PYRIDIN-2-YL-SS-ALANINATE 3-[(3-AMINO-4-METHYLAMINO-BENZOYL)-PYRIDIN-2-YL-AMINO]-PROPIONIC ACID ETHYL ESTER 5-(2-Bromoethyl)-2,3-dihydrobenzofuran Dabigatran etexilate Dabigatran Etexilate Mesylate N-(4-CYANO-PHENYL)-GLYCINE (4-CYANO-PHENYLAMINO)-ACETIC ACID TERT-BUTYL ESTER ethyl 2-[(4-cyanophenyl)amino]acetate 1-(4-cyanophenyl)-4-hydroxypyrrolidine-2-carboxylic acid (S)-N-(4-CYANO-2-NITRO-PHENYL)-L-TYROSINE N-(4-Cyanophenyl)-L-proline methyl 2-[(4-cyanophenyl)(methyl)amino]acetate (3AR,4S,9BS)-8-CYANO-3A,4,5,9B-TETRAHYDRO-3H-CYCLOPENTA[C]QUINOLINE-4-CARBOXYLIC ACID

  • N-(4-CYANO-PHENYL)-GLYCINE
  • Dabigatran Intermediate 2
  • Dabigatran Impurity 2 (DABRC-02)
  • N-(4-Cyanophenyl)glycine CAS:42288-26-6
  • [(4-Cyanophenyl)aMino]acetic Acid
  • 4-(((Carboxy)Methyl)aMino)benzonitrile
  • N-(p-Cyanophenyl)glycine
  • Dabigatran pharMaceutical interMediate
  • Glycine, N-(4-cyanophenyl)-
  • Dabigatran Etexilate Intermediate 2
  • <i>N</i>-(4-Cyanophenyl)glycine
  • 4-Cyano phenyl Glycine
  • N-(4-Cyanophenyl)glycine &gt
  • N-(4-CYANO-PHENYL)-GLYCIN
  • N-(4-Cynophenyl)-Glycine
  • N-(4-Cyanophenyl)glycine(DG10)
  • Pradaxa mesylate intermediates，N-(4-cyanophenyl)-Glycine
  • N-(4-cyano-phenyl)-glycine (DBE-102)
  • Dabigatran Impurity 2/Dabigatran Impurity 24
  • 2-(4-Cyanophenylamino) acetic acid (DGSB)
  • 2-((4-cyanophenyl)amino)aceticacid (DBI)
  • 2-((4-Cyanophenyl)amino)aceticaci
  • [(4-Cyanophenyl)amino]aceitic acid
  • DBEA- N-(4-cyanophenyl)glycine
  • Dabigatran Impurity 2 N-(4-Cyanophenyl)glycine
  • N-(4-Cyanophenyl)glycine, 98%
  • N - (4-cyanophenyl) aminoacetic acid
  • 4-Chloro-6,7-dimethoxyquioline (Intermediate of Cabozantinib malate)
  • 42288-26-6
  • 2288-26-6
  • 4288-26-6
  • For API's Production
  • Intermediate of Dabigatran
  • Aromatics
  • Intermediates & Fine Chemicals
  • Pharmaceuticals