3-[(3-AMINO-4-METHYLAMINO-BENZOYL)-PYRIDIN-2-YL-AMINO]-PROPIONIC ACID ETHYL ESTER

Product Name: 3-[(3-AMINO-4-METHYLAMINO-BENZOYL)-PYRIDIN-2-YL-AMINO]-PROPIONIC ACID ETHYL ESTER
CAS No.: 212322-56-0
Chemical Name: 3-[(3-AMINO-4-METHYLAMINO-BENZOYL)-PYRIDIN-2-YL-AMINO]-PROPIONIC ACID ETHYL ESTER
Synonyms: Ethyl 3-(3-amino-4-(methylamino)-N-(pyridin-2-yl)benzamido)propanoate;Ethyl N-[3-aMino-4-(MethylaMino)benzoyl]-N-pyridin-2-yl-beta-alaninate;β-Alanine, N-[3-aMino-4-(MethylaMino)benzoyl]-N-2-pyridinyl-, ethyl ester;route1 intermediate3;Dabigatran iMpurity P;Dabigatran Impurity n;Dabigatran Impurity 17;Dabigatran InterMediate;Dabigatran Intermediate 1;Dabigatran Intermediate F
CBNumber: CB31010276
Molecular Formula: C18H22N4O3
Formula Weight: 342.4
MOL File: 212322-56-0.mol

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3-[(3-AMINO-4-METHYLAMINO-BENZOYL)-PYRIDIN-2-YL-AMINO]-PROPIONIC ACID ETHYL ESTER Property

Melting point:: 104.0 to 108.0 °C
Boiling point:: 576.2±50.0 °C(Predicted)
Density: 1.261±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 5.37±0.11(Predicted)
color: Off-White to Pale Beige
InChI: InChI=1S/C18H22N4O3/c1-3-25-17(23)9-11-22(16-6-4-5-10-21-16)18(24)13-7-8-15(20-2)14(19)12-13/h4-8,10,12,20H,3,9,11,19H2,1-2H3
InChIKey: PCPATNZTKBOKOY-UHFFFAOYSA-N
SMILES: N(C1N=CC=CC=1)(CCC(=O)OCC)C(C1C=CC(NC)=C(N)C=1)=O
LogP: 1.37 at 20℃

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Safety

HS Code: 2933.39.9200

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: E1033
Product name: Ethyl 3-[3-Amino-4-(methylamino)-N-(2-pyridyl)benzamido]propionate
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $26
Updated: 2025/07/31

TCI Chemical

Product number: E1033
Product name: Ethyl 3-[3-Amino-4-(methylamino)-N-(2-pyridyl)benzamido]propionate
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $86
Updated: 2025/07/31

TRC

Product number: A611990
Product name: N-[3-Amino-4-(methylamino)benzoyl]-N-2-pyridinyl-β-alanineEthylEster
Packaging: 50g
Price: $250
Updated: 2021/12/16

AK Scientific

Product number: X1036
Product name: Ethyl3-(3-Amino-4-(methylamino)-N-(pyridin-2yl)benzamido)propanoate
Packaging: 100g
Price: $274
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: APN0002370
Product name: 3-[(3-AMINO-4-METHYLAMINO-BENZOYL)PYRIDINE-2-YL-AMINO]PROPIONIC ACID ETHYL-ESTER
Purity: 95.00%
Packaging: 5MG
Price: $457.38
Updated: 2021/12/16

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3-[(3-AMINO-4-METHYLAMINO-BENZOYL)-PYRIDIN-2-YL-AMINO]-PROPIONIC ACID ETHYL ESTER Chemical Properties,Usage,Production

Uses

Alzheimer's disease therapeutic, Co Q10 analog, antioxidant

Uses

Ethyl 3-(3-amino-4-(methylamino)-N-(pyridin-2-yl)benzamido)propanoate is the impurity of Dabigatran (D100090), which is a nonpeptide, direct thrombin inhibitor and is antithrombotic.

Synthesis

429659-01-8

212322-56-0

(D) Preparation of Intermediate VI: In a hydrogenation reactor, 43 g of ethyl 3-(4-(methylamino)-3-nitro-N-(pyridin-2-yl)benzoylamino)propionate and 4.7 g of nickel Nguyenne catalyst were added. 4 mL of tetrahydrofuran was added as solvent and three nitrogen substitutions were performed to remove air. The reaction mixture was then stirred under hydrogen atmosphere and heated to 60°C. The reaction process was monitored by thin layer chromatography (TLC). After completion of the reaction, a filtration operation was carried out and the filter cake was washed with a small amount of tetrahydrofuran. The filter cake was recovered and disposed properly. The filtrate was dried over anhydrous sodium sulfate, diafiltrated again and finally concentrated to dryness under reduced pressure to give 38.3 g of intermediate VI (6) in 96% yield.

References

[1] Patent: CN104031031, 2017, B. Location in patent: Paragraph 0028; 0033; 0035; 0040; 0042; 0047
[2] Patent: WO2007/71742, 2007, A1. Location in patent: Page/Page column 22-23
[3] Patent: WO2007/71743, 2007, A1. Location in patent: Page/Page column 18
[4] Patent: CN105461688, 2016, A. Location in patent: Paragraph 0043; 0044
[5] Patent: WO2007/71742, 2007, A1. Location in patent: Page/Page column 22

3-[(3-AMINO-4-METHYLAMINO-BENZOYL)-PYRIDIN-2-YL-AMINO]-PROPIONIC ACID ETHYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3-[(3-AMINO-4-METHYLAMINO-BENZOYL)-PYRIDIN-2-YL-AMINO]-PROPIONIC ACID ETHYL ESTER manufacturers

Anhuyan (Hainan) Biotechnology Co., LTD

Product: 3-[(3-AMINO-4-METHYLAMINO-BENZOYL)-PYRIDIN-2-YL-AMINO]-PROPIONIC ACID ETHYL ESTER 212322-56-0
Price: US $0.00-0.00/KG
Min. Order: 0.0001KG
Purity: 99%
Supply Ability: 2000000T
Release date: 2025-06-16

Henan Aochuang Chemical Co.,Ltd.

Product: Ethyl 3-(3-amino-4-(methylamino)-N-(pyridin-2-yl)benzamido)propanoate 212322-56-0
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-08

Shanghai Joiny Pharmaceutical Co.,LTD

Product: 3-[(3-Amino-4-methylaminobenzoyl)pyridin-2-ylamino]propionic acid ethyl ester 212322-56-0
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000kg
Release date: 2024-12-05

212322-56-0, 3-[(3-AMINO-4-METHYLAMINO-BENZOYL)-PYRIDIN-2-YL-AMINO]-PROPIONIC ACID ETHYL ESTERRelated Search:

3-(S)-(+)-(1-Carbamoyl-1,1-diphenylmethyl)pyrroloidine-L-(+)-tartarate Dabigatran Etexilate Mesylate Dabigatran etexilate Dabigatran Chloroacetic anhydride HEXYL CHLOROFORMATE N-[[2-[[[4-(Aminoiminomethyl)phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-(2-pyridinyl)-beta-alanine ethyl ester hydrochloride Minoxidil Ciprofloxacin hydrochloride 4-Aminobenzamidine dihydrochloride N-[[2-[[[4-(Aminoiminomethyl)phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]arbonyl]-N-2-pyridinyl-beta-alanine ethyl ester 4-methylbenzenesulfonate N-[2]PYRIDYL-B-ALANIN-ETHYL ESTER Dabigatran ethyl AcOH Salt ETHYL N-[4-(METHYLAMINO)-3-NITROBENZOYL]-N-PYRIDIN-2-YL-SS-ALANINATE 3-[[[2-[[(4-Cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]pyridin-2-ylamino]propionic acid ethyl ester N-(4-CYANO-PHENYL)-GLYCINE 5-(2-Bromoethyl)-2,3-dihydrobenzofuran N-(4-Aminobenzoyl)-beta-alanine

3-[(3-AMINO-4-METHYLAMINO-BENZOYL)-PYRIDIN-2-YL-AMINO]-PROPIONIC ACID ETHYL ESTER

Ethyl 3-(3-amino-4-(methylamino)-N-(pyridin-2-yl)benzamido)propanoate

Dabigatran Intermediate 1

N-[3-amino-4-(methylamino)benzoyl]-N-2-pyridinyl-β-Alanine,ethylester

Ethyl 3-{1-[3-aMino-4-(MethylaMino)-phenyl]-N-(pyridin-2-yl)-forMaMido}-propanoate

3-[3-aMino-4-(MethylaMinobenzoyl)-pyridin-2-ylaMni] propionic acid ethyl ester

Ethyl N-[3-aMino-4-(MethylaMino)benzoyl]-N-pyridin-2-yl-beta-alaninate

Dabigatran InterMediate

β-Alanine, N-[3-aMino-4-(MethylaMino)benzoyl]-N-2-pyridinyl-, ethyl ester

3-(3-AMINO-4-MethylAMINOBENZYL) PYRIDIN-2-YL-AMINO) PROPIONIC ACID ETHYL ESTER

ethyl (2S)-2-{1-[3-aMino-4-(MethylaMino)phenyl]-N-(pyridin-2-yl)forMaMido}propanoate

3-[(3-AMINO-4-METHYLAMINOBENZOYL)PYRIDIN-2-YLAMINO]PROPIONIC ACID ETHYL ESTE

Ethyl 3-(3-amino-4-(methylamino)-N-(pyridin-2-yl)benz

N-[3-aMino-4-(MethylaMino)benzoyl]-N-2-pyridinyl-, ethyl ester Alanine

Dabigatran iMpurity P

Ethyl 3-(4-(MethylaMino)-3-aMino-N-(pyridin-2-yl)benzaMido)-propanoate

3-[(3-AMINO-4-METHYLAMINO-BENZOYL)-PYRIDIN-2-YL-AMI

Ethyl 3-[3-Amino-4-(methylamino)-N-(2-pyridyl)benzamido]propionate

Dabigatran Impurity n

Dabigatran Etexilate Intermediate 1

Dabigatran Methylamino Impurity

ethyl 3-[[3-amino-4-(methylamino)benzoyl]-pyridin-2-ylamino]propanoate

N- [4- methyl 3-amino-benzoyl] N-2- pyridyl -b- alanine ethyl ester

route1 intermediate3

3-amino-4-methylamino-benzoic acid-N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)amide

Dabigatran Etexilate Mesylate impurity P

Ethyl 3-[3-Amino-4-(methylamino)-<i>N</i>-(2-pyridyl)benzamido]propionate

RE-EXP.OF REJECTED GOODS) 3-((3-AMINO-4-METHYLAMINOBENZOYL)PYRIDIN-2-YLAMINO) PROPIONIC ACID ETHYL ESTER

3-N-[4-(Methylamino)-3-aminobenzoyl]-N-2-pyridinyl-alanine ethyl ester

Ethyl 3-[[3-amino-4-(methylamino)benzoyl](pyridin-2-yl)amino]propionate

Dabigatran Impurity 17

Ethyl3-[3-Amino-4-(methylamino)-N-(2-pyridyl)benzamido]propionate&gt

Dabigatran Etexilate Impurity 17

Ethyl N-[3-amino-4-(methylamino)benzoyl]-N-pyridin-2-yl-β-alaninate

3-[(3-amino-4-methylamino-benzoyl)-pyridin-2-yl-amino]- propionic acid ethyl ester（DG07）

3-[3-Amino-4-(methylamino)-N-(2-pyridyl)benzamido]propionic Acid Ethyl Ester

Pradaxa mesylate intermediates，Ethyl N-[3-amino-4- (methylamino)benzoyl]-N-pyridin-2-yl- beta-alaninate

N-[3-Amino-4-(methylamino)benzoyl]-N-2-pyridinyl-β-alanine Ethyl Ester

3-[(3-amino-4-methyl amino benzyl) pyridine-2-yl-amino propionic acid ethyl ester. (DBE-101)

3-[(3-A-4-MAB pyridine-2-ylamino]propionicacid ethyl ester

3-[(3-amino-4-methylamino-benzoyl) pyridine-2-yl] propionate, ethyl ester

ethyl N-[3-amino-4-(methylamino)benzoyl]-N-pyridin-2-yl-beta...

N-[3-Amino-4-(methylamino)benzoyl]-N-2-pyridinyl-Beta-alanine Ethyl Ester

N-[3-amibno-4-(methylamino)benzoyl]-N-2-pyridinyl-,b-alanine ethyl ester

N-[[3-Amino-4-(Methylamino) Phenyl] Carbonyl]-N-(2-Pyridinyl)-Beta- Alanine Ethylester)

Ethyl 3-[[3-Amino-4-(methylamino)benzoyl]-(2-pyridyl)amino]propanoate (N-[3-Amino-4-(methylamino)benzoyl]-N-2-pyridinyl-β-alanine Ethyl Ester)

Ethyl 3-[[3-Amino-4-(methylamino)benzoyl]-(2-pyridyl)amino]propanoate (N-[3-Amino-4-(methylamino)benzoyl]-N-2-pyridinyl-beta-alanine Ethyl Ester)

3-[(3-AMINO-4-METHYLAMINO-BENZOYL)-PYRIDIN-2-YL-AMINO]-PROPIONIC ACID ETHYL ESTER，Dabigatran Intermediate

Ethyl 3-[{[3-amino-4-(methylamino)phenyl]carbonyl}(pyridin-2-yl)amino]propanoate

ETHYL3-(3-AMINO-4-(METHYLAMINO)-N-(PYRIDIN-2-YL)BENZAMIDO)PROPANOATE (DBG1)

3-[(3-Amino-4-methylaminobenzoyl)pyridin-2-ylamino]propionic

Ethyl-3{[3-amino-4-methylamino)benzoyl] (pyridine-2-yl) amino) propanoate

Ethyl 3-[{[3-amino-4- (methylamino)phenyl]carbonyl}(pyridin-2- yl)amino]propanoate (DG-3)

3-[(3-Amino-4-methylamino benzoyl)pyridine-2- yl amino]propionic acid ethyl ester

Ethyl 3-(3-Amino-4-(methylamino)-N-Pyridine-2yl)benzamido Propanoate

Material name: Ethyl 3-[(3-Amino-4-Methylamino-Benzoyl)-Pyridin-2-yl-Amino]-Propionate

Ethyl-3-Amino-4-(methylamino)-N-(Pyridin-2- yl)Benzamido)Propionate

Ethyl 3-[(3-Amino-4-Methylamino-Benzoyl)-Pyridin-2-Yl-Am