Chloroacetic anhydride

Product Name: Chloroacetic anhydride
CAS No.: 541-88-8
Chemical Name: Chloroacetic anhydride
Synonyms: 2-Chloroacetic anhydride;Monochloroacetic anhydride;CHLOROACETIC ACID ANHYDRIDE;MONOCHLOROACETIC ACID ANHYDRIDE;NSC 71207;oroacetic anhydride;chloraceticanhydride;chloroacetylanhydride;Chloracetic anhydride;CHLOROACETIC ANHYDRIDE
CBNumber: CB4853783
Molecular Formula: C4H4Cl2O3
Formula Weight: 170.97
MOL File: 541-88-8.mol

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Chloroacetic anhydride Property

Melting point:: 51 °C
Boiling point:: 203 °C
Density: 1.449
vapor pressure: <0.75 mm Hg ( 20 °C)
refractive index: 1.4730 (estimate)
Flash point:: >230 °F
storage temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility: Freely soluble in ether, chloroform. Slightly soluble in benzene. Insoluble in cold ligroin
form: Crystals, Chunks or Low Melting Mass
color: brown
Sensitive: Moisture Sensitive
Merck: 14,2113
BRN: 774533
Stability:: Moisture Sensitive
InChIKey: PNVPNXKRAUBJGW-UHFFFAOYSA-N
CAS DataBase Reference: 541-88-8(CAS DataBase Reference)
EPA Substance Registry System: Acetic acid, chloro-, anhydride (541-88-8)

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Safety

Hazard Codes: C,T
Risk Statements: 34-36/37-43-25
Safety Statements: 26-28-36/37/39-45-27
RIDADR: UN 3261 8/PG 2
WGK Germany: 3
F: 10-19-21
Hazard Note: Highly Toxic/Corrosive/Lachrymator
TSCA: Yes
HazardClass: 8
PackingGroup: II
HS Code: 29159000
Hazardous Substances Data: 541-88-8(Hazardous Substances Data)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 215163
Product name: Chloroacetic anhydride
Purity: 95%
Packaging: 25g
Price: $216
Updated: 2024/03/01

Sigma-Aldrich

Product number: 215163
Product name: Chloroacetic anhydride
Purity: 95%
Packaging: 100g
Price: $352
Updated: 2024/03/01

Alfa Aesar

Product number: A14015
Product name: Chloroacetic anhydride, 97%
Packaging: 25g
Price: $52.5
Updated: 2024/03/01

Alfa Aesar

Product number: A14015
Product name: Chloroacetic anhydride, 97%
Packaging: 100g
Price: $106
Updated: 2024/03/01

Alfa Aesar

Product number: A14015
Product name: Chloroacetic anhydride, 97%
Packaging: 500g
Price: $375.65
Updated: 2024/03/01

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Chloroacetic anhydride Chemical Properties,Usage,Production

Chemical Properties

brownish semi-transparent crystals, chunks or low

Uses

Chloroacetic anhydride has been used in the synthesis of 3,3-bis(sulfonato)-4,4-bis(chloroacetamido)azobenzene (BSBCA), a water-soluble, thiol-reactive and photo-switchable cross-linker, D,L-7-azatryptophan, 2-methyl-[3,4-di-O-acetyl-6-O-(chloroacetyl)-1,2-dideoxy-α-D-glucopyrano]-[2,1:4,5]-2-oxazoline.

Uses

In N-acetylation of amino acids in alkaline solution; preparation of cellulose chloroacetates.

Preparation

chloroacetic anhydride Synthesis: Powdered s odium monochloroacetate(113.3g, 1.138 mol) was added slowly for a period of 15 min at room temperature (which slowly raises to 60°C) to a stirred solution of commercially available chloroaceyl chloride (127.5g, 1mol) in dry benzene (136mL) was refluxed for 9h. Salts were filtered off, the filtrate was cooled to room temperature, diluted with n-hexane and further cooled to 0°C. The solid separated was then filtered, washed with dry hexane and dried to yield chloroacetic anhydride as white crystalline compound in 60% yield (80g); mp=46-49°C [Lit. mp=46°C]. Alternatively, the benzene layer was directly subjected to high vacuum distillation.The product collected at 109-10°C at 10mm vacuum on cooling chloroacetic anhydride in lump form in 70 % yield (93g). It was observed that, the latter method gives anhydride in lump form while the former method gives in crystalline form.

Purification Methods

Crystallise the it from *benzene. [Eglinton et al. J Chem Soc 1860 1954, Beilstein 2 IV 487.]

Chloroacetic anhydride Preparation Products And Raw materials

Raw materials

Preparation Products

D(+)-Tryptophan L-Tryptophan 2-Dimethylaminoethyl chloride hydrochloride Acetophenone

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Chloroacetic anhydride Suppliers

Belgium 3 Canada 1 China 127 Europe 1 Germany 5 India 6 Japan 5 Slovakia 1 South Korea 1 Switzerland 4 United Kingdom 9 United States 22 Global 185

Jia Xing Isenchem Co.,Ltd

Tel: 0573-85285100 18627885956
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Email: isenchem@163.com
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Shanghai Arbor Chemical Co., Ltd.

Tel: 021-021-60451683 15021268886
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Email: sales@arborchemical.com
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Twochem Co.Ltd.

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Bayee Biotech (Anqing) Co., Ltd.

Tel: 0556-5032306 18917961636
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Email: wtx@bayeebio.com
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Henan Huawen Chemical Co., Ltd

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Shangqiu Ladybug Network Technology Co., LTD

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Meryer (Shanghai) Chemical Technology Co., Ltd.

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Beijing Donghualituo Techonlogy Development Co.,Ltd.

Tel: 010-88425576
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Email: sales@dhltchem.com
Country: China
ProdList: 793
Advantage: 59

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
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Energy Chemical

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ProdList: 44751
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View Lastest Price from Chloroacetic anhydride manufacturers

Shaanxi Haibo Biotechnology Co., Ltd

Product: Chloroacetic anhydride 541-88-8
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 97%
Supply Ability: 10000 Mt/Year
Release date: 2023-08-23

Hebei Mojin Biotechnology Co., Ltd

Product: Chloroacetic anhydride 541-88-8
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2023-06-26

Hebei Guanlang Biotechnology Co,.LTD

Product: Chloroacetic Anhydride 541-88-8
Price: US $10.50/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 ton
Release date: 2021-07-02

541-88-8, Chloroacetic anhydrideRelated Search:

Dabigatran Etexilate Mesylate 3-[[[2-[[(4-Cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]pyridin-2-ylamino]propionic acid ethyl ester Dabigatran etexilate Dabigatran N-(4-CYANO-PHENYL)-GLYCINE 4-Aminobenzamidine dihydrochloride 3-[(3-AMINO-4-METHYLAMINO-BENZOYL)-PYRIDIN-2-YL-AMINO]-PROPIONIC ACID ETHYL ESTER HEXYL CHLOROFORMATE N-[[2-[[[4-(Aminoiminomethyl)phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-(2-pyridinyl)-beta-alanine ethyl ester hydrochloride DICHLOROACETIC ANHYDRIDE TRICHLOROACETIC ANHYDRIDE Dichloromaleic anhydride Chloroacetic anhydride CHLORODIFLUOROACETIC ANHYDRIDE Chloroacetic acid Acetic anhydride Acetic acid (chloroacetic)anhydride CHLOROACETIC ANHYDRIDE, [2-14C]

chloro-aceticacianhydride

Chloroacetyl anhydride

chloroacetylanhydride

chloroethanoicanhydride

Monochloroacetic anhydride

sym-dichloroaceticanhydride

CHLOROACETIC ANHYDRIDE

CHLOROACETIC ACID ANHYDRIDE

BIS(CHLOROACETIC)ANHYDRIDE

MONOCHLOROACETIC ACID ANHYDRIDE

2-Chloroacetic anhydride

2-chloroaceticanhydride

Aceticacid,chloro-,anhydride

alpha,alpha’-dichloroaceticanhydride

Chloracetic anhydride

chloraceticanhydride

CHLOROACETIC ANHYDRIDE, TECH., APPROX. 9 0%

Chloroaceticanhydride,97%

(Bischloroacetic acid) anhydride

NSC 71207

1,5-Dichloro-3-oxapentan-2,4-dione, 1,5-Dichloro-2,4-dioxo-3-oxapentane

Chloroacetic anhydride, tech., 90%

Chloroacetic anhydride 97%

Chloroacetic anhydride. 90%, tech

Monochloroaceitc acid anhydride

syMDichloroaceitc anhydride

Chloroacetic anhydride, 97% 25GR

oroacetic anhydride

Acetic acid, 2-chloro-, 1,1'-anhydride

541-88-8 Chloroacetic anhydride

541-88-8

ClCH2CO2O

C4H4O3Cl

C4H4Cl2O3

Organic Building Blocks

Building Blocks

Carbonyl Compounds

Carboxylic Acid Anhydrides

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Carbonyl Compounds

Carboxylic Acid Anhydrides

Chemical Synthesis

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Pharmaceutical Intermediates