Chloroacetic anhydride
- Product Name
- Chloroacetic anhydride
- CAS No.
- 541-88-8
- Chemical Name
- Chloroacetic anhydride
- Synonyms
- 2-Chloroacetic anhydride;Monochloroacetic anhydride;CHLOROACETIC ACID ANHYDRIDE;MONOCHLOROACETIC ACID ANHYDRIDE;NSC 71207;oroacetic anhydride;chloraceticanhydride;chloroacetylanhydride;Chloracetic anhydride;CHLOROACETIC ANHYDRIDE
- CBNumber
- CB4853783
- Molecular Formula
- C4H4Cl2O3
- Formula Weight
- 170.97
- MOL File
- 541-88-8.mol
Chloroacetic anhydride Property
- Melting point:
- 51 °C
- Boiling point:
- 203 °C
- Density
- 1.449
- vapor pressure
- <0.75 mm Hg ( 20 °C)
- refractive index
- 1.4730 (estimate)
- Flash point:
- >230 °F
- storage temp.
- Hygroscopic, -20°C Freezer, Under inert atmosphere
- solubility
- Freely soluble in ether, chloroform. Slightly soluble in benzene. Insoluble in cold ligroin
- form
- Crystals, Chunks or Low Melting Mass
- color
- brown
- Sensitive
- Moisture Sensitive
- Merck
- 14,2113
- BRN
- 774533
- Stability:
- Moisture Sensitive
- InChIKey
- PNVPNXKRAUBJGW-UHFFFAOYSA-N
- CAS DataBase Reference
- 541-88-8(CAS DataBase Reference)
- EPA Substance Registry System
- Acetic acid, chloro-, anhydride (541-88-8)
Safety
- Hazard Codes
- C,T
- Risk Statements
- 34-36/37-43-25
- Safety Statements
- 26-28-36/37/39-45-27
- RIDADR
- UN 3261 8/PG 2
- WGK Germany
- 3
- F
- 10-19-21
- Hazard Note
- Highly Toxic/Corrosive/Lachrymator
- TSCA
- Yes
- HazardClass
- 8
- PackingGroup
- II
- HS Code
- 29159000
- Hazardous Substances Data
- 541-88-8(Hazardous Substances Data)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 215163
- Product name
- Chloroacetic anhydride
- Purity
- 95%
- Packaging
- 25g
- Price
- $216
- Updated
- 2024/03/01
- Product number
- 215163
- Product name
- Chloroacetic anhydride
- Purity
- 95%
- Packaging
- 100g
- Price
- $352
- Updated
- 2024/03/01
- Product number
- A14015
- Product name
- Chloroacetic anhydride, 97%
- Packaging
- 25g
- Price
- $52.5
- Updated
- 2024/03/01
- Product number
- A14015
- Product name
- Chloroacetic anhydride, 97%
- Packaging
- 100g
- Price
- $106
- Updated
- 2024/03/01
- Product number
- A14015
- Product name
- Chloroacetic anhydride, 97%
- Packaging
- 500g
- Price
- $375.65
- Updated
- 2024/03/01
Chloroacetic anhydride Chemical Properties,Usage,Production
Chemical Properties
brownish semi-transparent crystals, chunks or low
Uses
Chloroacetic anhydride has been used in the synthesis of 3,3-bis(sulfonato)-4,4-bis(chloroacetamido)azobenzene (BSBCA), a water-soluble, thiol-reactive and photo-switchable cross-linker, D,L-7-azatryptophan, 2-methyl-[3,4-di-O-acetyl-6-O-(chloroacetyl)-1,2-dideoxy-α-D-glucopyrano]-[2,1:4,5]-2-oxazoline.
Uses
In N-acetylation of amino acids in alkaline solution; preparation of cellulose chloroacetates.
Preparation
chloroacetic anhydride Synthesis: Powdered s odium monochloroacetate(113.3g, 1.138 mol) was added slowly for a period of 15 min at room temperature (which slowly raises to 60°C) to a stirred solution of commercially available chloroaceyl chloride (127.5g, 1mol) in dry benzene (136mL) was refluxed for 9h. Salts were filtered off, the filtrate was cooled to room temperature, diluted with n-hexane and further cooled to 0°C. The solid separated was then filtered, washed with dry hexane and dried to yield chloroacetic anhydride as white crystalline compound in 60% yield (80g); mp=46-49°C [Lit. mp=46°C]. Alternatively, the benzene layer was directly subjected to high vacuum distillation.The product collected at 109-10°C at 10mm vacuum on cooling chloroacetic anhydride in lump form in 70 % yield (93g). It was observed that, the latter method gives anhydride in lump form while the former method gives in crystalline form.
Purification Methods
Crystallise the it from *benzene. [Eglinton et al. J Chem Soc 1860 1954, Beilstein 2 IV 487.]
Chloroacetic anhydride Preparation Products And Raw materials
Raw materials
Preparation Products
Chloroacetic anhydride Suppliers
- Tel
- --
- Fax
- --
- chemcontrol@nextra.sk
- Country
- Slovakia
- ProdList
- 6700
- Advantage
- 60
View Lastest Price from Chloroacetic anhydride manufacturers
- Product
- Chloroacetic Anhydride 541-88-8
- Price
- US $10.50/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 ton
- Release date
- 2024-08-21
- Product
- Chloroacetic anhydride 541-88-8
- Price
- US $10.00/KG
- Min. Order
- 100KG
- Purity
- 99%
- Supply Ability
- 100 mt
- Release date
- 2021-08-25
- Product
- Chloroacetic anhydride 541-88-8
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 97%
- Supply Ability
- 10000 Mt/Year
- Release date
- 2023-08-23