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Chloroacetic anhydride

Product Name
Chloroacetic anhydride
CAS No.
541-88-8
Chemical Name
Chloroacetic anhydride
Synonyms
2-Chloroacetic anhydride;Monochloroacetic anhydride;CHLOROACETIC ACID ANHYDRIDE;MONOCHLOROACETIC ACID ANHYDRIDE;NSC 71207;oroacetic anhydride;chloraceticanhydride;chloroacetylanhydride;Chloracetic anhydride;CHLOROACETIC ANHYDRIDE
CBNumber
CB4853783
Molecular Formula
C4H4Cl2O3
Formula Weight
170.97
MOL File
541-88-8.mol
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Chloroacetic anhydride Property

Melting point:
51 °C
Boiling point:
203 °C
Density 
1.449
vapor pressure 
<0.75 mm Hg ( 20 °C)
refractive index 
1.4730 (estimate)
Flash point:
>230 °F
storage temp. 
Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility 
Freely soluble in ether, chloroform. Slightly soluble in benzene. Insoluble in cold ligroin
form 
Crystals, Chunks or Low Melting Mass
color 
brown
Sensitive 
Moisture Sensitive
Merck 
14,2113
BRN 
774533
Stability:
Moisture Sensitive
InChIKey
PNVPNXKRAUBJGW-UHFFFAOYSA-N
CAS DataBase Reference
541-88-8(CAS DataBase Reference)
EPA Substance Registry System
Acetic acid, chloro-, anhydride (541-88-8)
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Safety

Hazard Codes 
C,T
Risk Statements 
34-36/37-43-25
Safety Statements 
26-28-36/37/39-45-27
RIDADR 
UN 3261 8/PG 2
WGK Germany 
3
10-19-21
Hazard Note 
Highly Toxic/Corrosive/Lachrymator
TSCA 
Yes
HazardClass 
8
PackingGroup 
II
HS Code 
29159000
Hazardous Substances Data
541-88-8(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
215163
Product name
Chloroacetic anhydride
Purity
95%
Packaging
25g
Price
$216
Updated
2024/03/01
Sigma-Aldrich
Product number
215163
Product name
Chloroacetic anhydride
Purity
95%
Packaging
100g
Price
$352
Updated
2024/03/01
Alfa Aesar
Product number
A14015
Product name
Chloroacetic anhydride, 97%
Packaging
25g
Price
$52.5
Updated
2024/03/01
Alfa Aesar
Product number
A14015
Product name
Chloroacetic anhydride, 97%
Packaging
100g
Price
$106
Updated
2024/03/01
Alfa Aesar
Product number
A14015
Product name
Chloroacetic anhydride, 97%
Packaging
500g
Price
$375.65
Updated
2024/03/01
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Chloroacetic anhydride Chemical Properties,Usage,Production

Chemical Properties

brownish semi-transparent crystals, chunks or low

Uses

Chloroacetic anhydride has been used in the synthesis of 3,3-bis(sulfonato)-4,4-bis(chloroacetamido)azobenzene (BSBCA), a water-soluble, thiol-reactive and photo-switchable cross-linker, D,L-7-azatryptophan, 2-methyl-[3,4-di-O-acetyl-6-O-(chloroacetyl)-1,2-dideoxy-α-D-glucopyrano]-[2,1:4,5]-2-oxazoline.

Uses

In N-acetylation of amino acids in alkaline solution; preparation of cellulose chloroacetates.

Preparation

chloroacetic anhydride Synthesis: Powdered s odium monochloroacetate(113.3g, 1.138 mol) was added slowly for a period of 15 min at room temperature (which slowly raises to 60°C) to a stirred solution of commercially available chloroaceyl chloride (127.5g, 1mol) in dry benzene (136mL) was refluxed for 9h. Salts were filtered off, the filtrate was cooled to room temperature, diluted with n-hexane and further cooled to 0°C. The solid separated was then filtered, washed with dry hexane and dried to yield chloroacetic anhydride as white crystalline compound in 60% yield (80g); mp=46-49°C [Lit. mp=46°C]. Alternatively, the benzene layer was directly subjected to high vacuum distillation.The product collected at 109-10°C at 10mm vacuum on cooling chloroacetic anhydride in lump form in 70 % yield (93g). It was observed that, the latter method gives anhydride in lump form while the former method gives in crystalline form.

Purification Methods

Crystallise the it from *benzene. [Eglinton et al. J Chem Soc 1860 1954, Beilstein 2 IV 487.]

Chloroacetic anhydride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Chloroacetic anhydride manufacturers

Shaanxi Haibo Biotechnology Co., Ltd
Product
Chloroacetic anhydride 541-88-8
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
97%
Supply Ability
10000 Mt/Year
Release date
2023-08-23
Hebei Mojin Biotechnology Co., Ltd
Product
Chloroacetic anhydride 541-88-8
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-06-26
Hebei Guanlang Biotechnology Co,.LTD
Product
Chloroacetic Anhydride 541-88-8
Price
US $10.50/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 ton
Release date
2021-07-02

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