ChemicalBook > CAS DataBase List > Chloroacetic anhydride

Chloroacetic anhydride

Product Name
Chloroacetic anhydride
CAS No.
541-88-8
Chemical Name
Chloroacetic anhydride
Synonyms
2-Chloroacetic anhydride;Monochloroacetic anhydride;CHLOROACETIC ACID ANHYDRIDE;MONOCHLOROACETIC ACID ANHYDRIDE;NSC 71207;oroacetic anhydride;chloraceticanhydride;chloroacetylanhydride;Chloracetic anhydride;CHLOROACETIC ANHYDRIDE
CBNumber
CB4853783
Molecular Formula
C4H4Cl2O3
Formula Weight
170.97
MOL File
541-88-8.mol
More
Less

Chloroacetic anhydride Property

Melting point:
51 °C
Boiling point:
203 °C
Density 
1.449
vapor pressure 
<0.75 mm Hg ( 20 °C)
refractive index 
1.4730 (estimate)
Flash point:
>230 °F
storage temp. 
Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility 
Freely soluble in ether, chloroform. Slightly soluble in benzene. Insoluble in cold ligroin
form 
Crystals, Chunks or Low Melting Mass
color 
brown
Sensitive 
Moisture Sensitive
Merck 
14,2113
BRN 
774533
Stability:
Moisture Sensitive
InChIKey
PNVPNXKRAUBJGW-UHFFFAOYSA-N
CAS DataBase Reference
541-88-8(CAS DataBase Reference)
EPA Substance Registry System
Acetic acid, chloro-, anhydride (541-88-8)
More
Less

Safety

Hazard Codes 
C,T
Risk Statements 
34-36/37-43-25
Safety Statements 
26-28-36/37/39-45-27
RIDADR 
UN 3261 8/PG 2
WGK Germany 
3
F 
10-19-21
Hazard Note 
Highly Toxic/Corrosive/Lachrymator
TSCA 
Yes
HazardClass 
8
PackingGroup 
II
HS Code 
29159000
Hazardous Substances Data
541-88-8(Hazardous Substances Data)
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
215163
Product name
Chloroacetic anhydride
Purity
95%
Packaging
25g
Price
$216
Updated
2024/03/01
Sigma-Aldrich
Product number
215163
Product name
Chloroacetic anhydride
Purity
95%
Packaging
100g
Price
$352
Updated
2024/03/01
Alfa Aesar
Product number
A14015
Product name
Chloroacetic anhydride, 97%
Packaging
25g
Price
$52.5
Updated
2024/03/01
Alfa Aesar
Product number
A14015
Product name
Chloroacetic anhydride, 97%
Packaging
100g
Price
$106
Updated
2024/03/01
Alfa Aesar
Product number
A14015
Product name
Chloroacetic anhydride, 97%
Packaging
500g
Price
$375.65
Updated
2024/03/01
More
Less

Chloroacetic anhydride Chemical Properties,Usage,Production

Chemical Properties

brownish semi-transparent crystals, chunks or low

Uses

Chloroacetic anhydride has been used in the synthesis of 3,3-bis(sulfonato)-4,4-bis(chloroacetamido)azobenzene (BSBCA), a water-soluble, thiol-reactive and photo-switchable cross-linker, D,L-7-azatryptophan, 2-methyl-[3,4-di-O-acetyl-6-O-(chloroacetyl)-1,2-dideoxy-α-D-glucopyrano]-[2,1:4,5]-2-oxazoline.

Uses

In N-acetylation of amino acids in alkaline solution; preparation of cellulose chloroacetates.

Preparation

chloroacetic anhydride Synthesis: Powdered s odium monochloroacetate(113.3g, 1.138 mol) was added slowly for a period of 15 min at room temperature (which slowly raises to 60°C) to a stirred solution of commercially available chloroaceyl chloride (127.5g, 1mol) in dry benzene (136mL) was refluxed for 9h. Salts were filtered off, the filtrate was cooled to room temperature, diluted with n-hexane and further cooled to 0°C. The solid separated was then filtered, washed with dry hexane and dried to yield chloroacetic anhydride as white crystalline compound in 60% yield (80g); mp=46-49°C [Lit. mp=46°C]. Alternatively, the benzene layer was directly subjected to high vacuum distillation.The product collected at 109-10°C at 10mm vacuum on cooling chloroacetic anhydride in lump form in 70 % yield (93g). It was observed that, the latter method gives anhydride in lump form while the former method gives in crystalline form.

Purification Methods

Crystallise the it from *benzene. [Eglinton et al. J Chem Soc 1860 1954, Beilstein 2 IV 487.]

Chloroacetic anhydride Preparation Products And Raw materials

Raw materials

Preparation Products

D-Tryptophan L-Tryptophan 2-Dimethylaminoethyl chloride hydrochloride Acetophenone
More
Less

Chloroacetic anhydride Suppliers

Belgium 3 Canada 1 China 139 Europe 1 Germany 5 India 6 Japan 5 Slovakia 1 South Korea 1 Switzerland 4 United Kingdom 9 United States 22 Global 197
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9413
Advantage
66
Shanghai Arbor Chemical Co., Ltd.
Tel
021-60451683 15021268886
Fax
+86-21-60451682
Email
sales@arborchemical.com
Country
China
ProdList
853
Advantage
55
Twochem Co.Ltd.
Tel
021-58111628 15800915896
Fax
QQ 3285589261
Email
sales@twochem.com
Country
China
ProdList
1788
Advantage
58
Bayee Biotech (Anqing) Co., Ltd.
Tel
0556-5032306 18917961636
Fax
+86-556-5032307
Email
wtx@bayeebio.com
Country
China
ProdList
259
Advantage
61
Henan Huawen Chemical Co., Ltd
Tel
0370-0370-2059268 17550075363
Fax
QQ:2712427897
Email
1124977392@qq.com
Country
China
ProdList
2283
Advantage
58
Shangqiu Ladybug Network Technology Co., LTD
Tel
0370-2070160 17550096163
Fax
18736733639
Email
2986449836@qq.com
Country
China
ProdList
3028
Advantage
58
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
Beijing Donghualituo Techonlogy Development Co.,Ltd.
Tel
010-88425576
Fax
(+86)-10-88425546
Email
sales@dhltchem.com
Country
China
ProdList
793
Advantage
59
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44689
Advantage
61
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9976
Advantage
60
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42958
Advantage
64
Shandong Xiya Chemical Co., Ltd
Tel
4009903999 13355009207
Fax
0539-6365991
Email
3007715519@qq.com
Country
China
ProdList
18738
Advantage
57
Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
12984
Advantage
57
Sichuan Kulinan Technology Co., Ltd
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11707
Advantage
57
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
Country
China
ProdList
14435
Advantage
57
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9815
Advantage
79
Nanjing Vital Chemical Co., Ltd.
Tel
Please Send Email 18652950785
Fax
025-87193546
Email
chemweiao@163.com
Country
China
ProdList
4378
Advantage
65
Aemon Chemical
Tel
0086-755-86198205
Email
acinfo@aemonchem.com
Country
China
ProdList
1931
Advantage
57
Maya High Purity Chemicals
Tel
+86 (573) 82222445 (0)18006601000 452520369
Fax
+86 (573) 82222643
Email
sales@maya-r.com
Country
China
ProdList
11707
Advantage
57
Chengdu Ai Keda Chemical Technology Co., Ltd.
Tel
4008-755-333 18080918076
Fax
028-86757656
Email
800078821@qq.com
Country
China
ProdList
9718
Advantage
55
Thermo Fisher Scientific
Tel
800-810-5118
Fax
+86-10-84193589
Email
cnchemical@thermofisher.com
Country
China
ProdList
17770
Advantage
75
Beijing innoChem Science & Technology Co.,Ltd.
Tel
400-810-7969 010-59572699
Fax
010-59572688
Email
ningzi.li@inno-chem.com.cn
Country
China
ProdList
6134
Advantage
55
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
22514
Advantage
55
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-400-6206333 18521732826
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
The future of Shanghai Industrial Co., Ltd.
Tel
021-61552785
Fax
021-55660885
Email
sales@shshiji.com
Country
China
ProdList
9545
Advantage
55
Quzhou Juhua Friendship Co., Ltd
Tel
0570-3066667
Fax
0570-3063388
Country
China
ProdList
3930
Advantage
58
Shanghai JONLN Reagent Co., Ltd.
Tel
400-0066400 13621662912
Fax
021-55660885
Email
422131432@qq.com
Country
China
ProdList
9978
Advantage
55
Huainan Kedi Chemical Factory
Tel
0554-2106669
Fax
0554-2666215
Email
sales1@kedichem.com
Country
China
ProdList
4924
Advantage
55
Chengdu HuaXia Chemical Reagent Co. Ltd
Tel
400-1166-196 13458535857
Fax
QQ：800101999
Email
cdhxsj@163.com
Country
China
ProdList
13350
Advantage
58
Wuxi Zhongkun Biochemical Technology Co., Ltd.
Tel
0510-85629785 18013409632
Fax
051085625359
Email
sales@reading-chemicals.com
Country
China
ProdList
15178
Advantage
58
Credit-Chem Co., Ltd.
Tel
400-821-5857 021-64326257
Fax
021-64393586 QQ;2798200800
Email
credit-chem@foxmail.com
Country
China
ProdList
5219
Advantage
58
Shanghai YuLue Chemical Co., Ltd.
Tel
021-60345187 13671753212
Fax
021-34702061
Email
lzz841106@aliyun.com
Country
China
ProdList
10276
Advantage
55
Shanghai Macklin Biochemical Co.,Ltd.
Tel
15221275939 15221275939
Fax
021-50706099
Email
shenlinxing@macklin.cn
Country
China
ProdList
16166
Advantage
55
Shanghai Song Yuan Chemical Technology Co., Ltd.
Tel
010-1234567 18521000990
Fax
86-021-33275113
Email
sonyuanchemical@163.com
Country
China
ProdList
6479
Advantage
50
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51456
Advantage
80
Zhengzhou KeYulong chemical products Co., Ltd
Tel
17319789407
Fax
0371-53335504
Email
Keyulongchem@163.com
Country
China
ProdList
1993
Advantage
55
Giant chemicals
Tel
028-85434334 18108076537
Fax
QQ：245797092
Email
market@gianthx.com
Country
China
ProdList
4505
Advantage
56
Codow Chemical Co.,Ltd.
Tel
18620099427
Fax
+86-20-62619665
Email
amy@howeipharm.com
Country
China
ProdList
17687
Advantage
55
Nanjing Vital Chemical Co., Ltd.
Tel
025-87193546 18652950785
Fax
025-87193546
Email
chemweiao@163.com
Country
China
ProdList
9021
Advantage
60
ShangHai Siyan Biological Technology Co., Ltd.
Tel
021-50908862，442785678，326799392 18721037013
Fax
021-50908862
Email
siyansales@126.com
Country
China
ProdList
9627
Advantage
58
Shanghai Xilong Biochemical Technology Co., Ltd.
Tel
021-52907766-8042
Fax
021-52906523
Country
China
ProdList
9941
Advantage
58
Shandong Xiya Chemical Co., Ltd.
Tel
4009903999 13395398332
Fax
0539-6365991
Email
sales@xiyashiji.com
Country
China
ProdList
20806
Advantage
60
Chengdu Dianchun Technology Co., Ltd
Tel
400-1166-196 18502815961
Fax
QQ：800101999
Email
cdhxsj@163.com
Country
China
ProdList
14603
Advantage
60
Grader reagent
Tel
18221735425
Email
sales@xinpingchem.com
Country
China
ProdList
9942
Advantage
58
Henan Jiuhua Biological Technology Co., Ltd.
Tel
15738884691 153248764872949584887 237654463
Fax
0371-55320919
Email
jiuhuabiochem@163.com
Country
China
ProdList
2750
Advantage
58
Shanghai Kangman Biological Technology Co., Ltd.
Tel
18800375331
Fax
021-50908862
Email
kangmansales@163.com
Country
China
ProdList
7570
Advantage
55
Shanghai Orgchem Co.,Ltd.
Tel
+86-21-5877 1921
Fax
+86-21-5877 1925
Email
info@chemofchina.com
Country
China
ProdList
9653
Advantage
55
Shandong Ono Chemical Co., Ltd.
Tel
0539-6362799 20）
Fax
0539-6362799（To 20）
Country
China
ProdList
10007
Advantage
58
Shanghai Darui Fine Chemicals Co., Ltd.
Tel
021-33922791-0 13816046603
Email
3368239663@qq.com
Country
China
ProdList
4287
Advantage
58
More
Less

View Lastest Price from Chloroacetic anhydride manufacturers

Hebei Chuanghai Biotechnology Co,.LTD
Product
Chloroacetic Anhydride 541-88-8
Price
US $10.50/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 ton
Release date
2024-08-21
Hebei Weibang Biotechnology Co., Ltd
Product
Chloroacetic anhydride 541-88-8
Price
US $10.00/KG
Min. Order
100KG
Purity
99%
Supply Ability
100 mt
Release date
2021-08-25
Shaanxi Haibo Biotechnology Co., Ltd
Product
Chloroacetic anhydride 541-88-8
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
97%
Supply Ability
10000 Mt/Year
Release date
2023-08-23

541-88-8, Chloroacetic anhydrideRelated Search:

Dabigatran Etexilate Mesylate 3-[[[2-[[(4-Cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]pyridin-2-ylamino]propionic acid ethyl ester Dabigatran etexilate Dabigatran N-(4-CYANO-PHENYL)-GLYCINE 4-Aminobenzamidine dihydrochloride 3-[(3-AMINO-4-METHYLAMINO-BENZOYL)-PYRIDIN-2-YL-AMINO]-PROPIONIC ACID ETHYL ESTER HEXYL CHLOROFORMATE N-[[2-[[[4-(Aminoiminomethyl)phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-(2-pyridinyl)-beta-alanine ethyl ester hydrochloride DICHLOROACETIC ANHYDRIDE TRICHLOROACETIC ANHYDRIDE Dichloromaleic anhydride Chloroacetic anhydride CHLORODIFLUOROACETIC ANHYDRIDE Chloroacetic acid Acetic anhydride Acetic acid (chloroacetic)anhydride CHLOROACETIC ANHYDRIDE, [2-14C]

  • chloro-aceticacianhydride
  • Chloroacetyl anhydride
  • chloroacetylanhydride
  • chloroethanoicanhydride
  • Monochloroacetic anhydride
  • sym-dichloroaceticanhydride
  • CHLOROACETIC ANHYDRIDE
  • CHLOROACETIC ACID ANHYDRIDE
  • BIS(CHLOROACETIC)ANHYDRIDE
  • MONOCHLOROACETIC ACID ANHYDRIDE
  • 2-Chloroacetic anhydride
  • 2-chloroaceticanhydride
  • Aceticacid,chloro-,anhydride
  • alpha,alpha’-dichloroaceticanhydride
  • Chloracetic anhydride
  • chloraceticanhydride
  • CHLOROACETIC ANHYDRIDE, TECH., APPROX. 9 0%
  • Chloroaceticanhydride,97%
  • (Bischloroacetic acid) anhydride
  • NSC 71207
  • 1,5-Dichloro-3-oxapentan-2,4-dione, 1,5-Dichloro-2,4-dioxo-3-oxapentane
  • Chloroacetic anhydride, tech., 90%
  • Chloroacetic anhydride 97%
  • Chloroacetic anhydride. 90%, tech
  • Monochloroaceitc acid anhydride
  • syMDichloroaceitc anhydride
  • Chloroacetic anhydride, 97% 25GR
  • oroacetic anhydride
  • Acetic acid, 2-chloro-, 1,1'-anhydride
  • 541-88-8 Chloroacetic anhydride
  • 541-88-8
  • ClCH2CO2O
  • C4H4O3Cl
  • C4H4Cl2O3
  • Organic Building Blocks
  • Building Blocks
  • Carbonyl Compounds
  • Carboxylic Acid Anhydrides
  • Building Blocks
  • Carbonyl Compounds
  • Carboxylic Acid Anhydrides
  • Chemical Synthesis
  • Organic Building Blocks
  • Pharmaceutical Intermediates