N-(4-Aminobenzoyl)-beta-alanine

Product Name: N-(4-Aminobenzoyl)-beta-alanine
CAS No.: 7377-08-4
Chemical Name: N-(4-Aminobenzoyl)-beta-alanine
Synonyms: 7377-08-4-;TIMTEC-BB SBB000472;N-(4-Aminobenzoyl)-;Balsalazide Impurity 5;Balsalazide Impurity 2;Balsalazide Aminobenzoyl;Balsalazide Amino Impurity;N-(4-Aminobenzoyl)--alanine;P-aminobenzoyl-beta-alanine;n-(4-aminobenzoyl)-á-alanine
CBNumber: CB1142204
Molecular Formula: C10H12N2O3
Formula Weight: 208.21
MOL File: 7377-08-4.mol

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N-(4-Aminobenzoyl)-beta-alanine Property

Melting point:: 152-154 °C(lit.)
Boiling point:: 347.41°C (rough estimate)
Density: 1.2420 (rough estimate)
vapor pressure: 0Pa at 20℃
refractive index: 1.4830 (estimate)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
solubility: DMSO, Methanol (Slightly), Water (Slightly, Heated)
form: Solid
pka: 4.36±0.10(Predicted)
color: White to Off-White
InChI: InChI=1S/C10H12N2O3/c11-8-3-1-7(2-4-8)10(15)12-6-5-9(13)14/h1-4H,5-6,11H2,(H,12,15)(H,13,14)
InChIKey: VHAXWROFYVPXMZ-UHFFFAOYSA-N
SMILES: C1(C=CC(N)=CC=1)C(=O)NCCC(=O)O
LogP: -1.19 at 25℃ and pH7.5
Surface tension: 71.6mN/m at 1g/L and 20℃
CAS DataBase Reference: 7377-08-4(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-37/39
WGK Germany: 3
HS Code: 2924.29.7790

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: A2347
Product name: N-(4-Aminobenzoyl)-beta-alanine
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $21
Updated: 2025/07/31

TCI Chemical

Product number: A2347
Product name: N-(4-Aminobenzoyl)-beta-alanine
Purity: >98.0%(HPLC)(T)
Packaging: 25g
Price: $56
Updated: 2025/07/31

TRC

Product number: A593795
Product name: N-(4-Aminobenzoyl)-β-alanine
Packaging: 10g
Price: $50
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA34152
Product name: N-(4-Aminobenzoyl)-beta-alanine - 25% aqueous solution
Packaging: 5G
Price: $60
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA34152
Product name: N-(4-Aminobenzoyl)-beta-alanine - 25% aqueous solution
Packaging: 10g
Price: $90
Updated: 2021/12/16

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N-(4-Aminobenzoyl)-beta-alanine Chemical Properties,Usage,Production

Description

N-(4-Aminobenzoyl)-beta-alanine is a molecule that was identified in the 1960s and has been used extensively for research purposes. It is a prodrug that is converted to salicylic acid in vivo. The drug has been shown to scavenge reactive oxygen species, inhibit the enzyme catalase, and protect against oxidative damage. N-(4-Aminobenzoyl)-beta-alanine also provides protection against colitis by inhibiting peroxide production and preventing oxidative damage of colon cells. This drug is orally active and may have potential clinical applications for patients with catalase deficiency or peroxide-mediated diseases such as colitis.

Chemical Properties

white to light orange-brown crystalline powder

Uses

N-(4-aminobenzoyl)-β-Alanine is a metabolite of BX661A, a therapeutic agent used in the treatment of ulcerative colitis, chemotaxis and reactive oxygen species production in polymorphonuclear leukocy ctes. Inhibits lipid peroxidation in large intestinal mucosa after mesenteric ischemia/reperfusion.

Definition

ChEBI: 4-Aminobenzoyl-(beta)-alanine is an organooxygen compound and an organonitrogen compound. It is functionally related to a beta-amino acid.

Synthesis

Step 1: 4-nitrobenzoyl-??-alanine sodium salt

In a 500 ml three-necked flask, ??-alanine (5.7 g, 64.86 mmol) was added sequentially, and 20 g of sodium hydroxide + 200 g of purified water formulated in aqueous sodium hydroxide solution was stirred to dissolve. The reaction temperature was allowed to drop to 5 ??C, and then 4-nitrobenzoyl chloride (little and often, 10 g, 54.05 mmol) was added. The reaction was carried out at a reaction temperature of 5??C for 3 h. An aqueous solution of the target product was obtained, which was directly cast to the next step without post-treatment.

Step 2: p-Aminobenzoyl-beta-alanine

In the 500 ml three-necked flask of the above reaction aqueous solution, Zr12-TPDC-Pd (0.5 g) was added, H2 was passed, and stirred, until no hydrogen was absorbed at room temperature and pressure. Then hydrochloric acid was slowly added to adjust PH = 1-2, and then stirred for 10 minutes to obtain p-aminobenzoyl-beta-alanine solution.

N-(4-Aminobenzoyl)-beta-alanine Preparation Products And Raw materials

Raw materials

Preparation Products

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N-(4-Aminobenzoyl)-beta-alanine Suppliers

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View Lastest Price from N-(4-Aminobenzoyl)-beta-alanine manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: N-(4-Aminobenzoyl)-beta-alanine 7377-08-4
Price: US $25.00/ASSAYS
Min. Order: 100ASSAYS
Purity: 99.5%
Supply Ability: 100 mt
Release date: 2024-11-18

Moxin Chemicals

Product: Balsalazide Impurity 2 7377-08-4
Price: US $0.00-0.00/mg
Min. Order: 10mg
Purity: 95%+
Supply Ability: 10000
Release date: 2025-03-07

Beijing Mediking Biopharm Co., Ltd

Product: N-(4-Aminobenzoyl)-β-alanine 7377-08-4
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 2tons
Release date: 2023-11-03

7377-08-4, N-(4-Aminobenzoyl)-beta-alanineRelated Search:

Benzoyl peroxide Calcium folinate p-Aminobenzamide β-Alanine DL-Alanine Propionic acid L-Alanine Dibenzoylmethane Glycine Balsalazide disodium Balsalazide N-(4-Nitrobenzoyl)-beta-alanine 3-[(3-AMINO-4-METHYLAMINO-BENZOYL)-PYRIDIN-2-YL-AMINO]-PROPIONIC ACID ETHYL ESTER N-[4-[[(2-Amino-1,4-dihydro-4-oxopteridin-6-yl)methyl]amino]benzoyl]-L-aspartic acid N-(4-Aminobenzoyl)-beta-alanine BALSALAZIDE-13C2,15N1 BALSALAZIDE-3-METHYL ANALOGUE DISODIUM SALT 3-[(3-methyl-4-nitrophenyl)formamido]propanoic acid

3-(4-AMINOBENZOYLAMINO)-PROPIONIC ACID

N-(4-AMINOBENZOYL)-BETA-ALANINE

TIMTEC-BB SBB000472

N-(4-AMINOBENZOYL)-BETA-ALANINE 97%

N-(4-Aminobenzoyl)-alanine,98%

N-(4-Aminobenzoyl)--alanine

N-(4-Aminobenzoyl)-b-alanine

n-(4-aminobenzoyl)-á-alanine

N-(P-AMINOBENZOYL)-BETA-ALANINE

N-(4-AMINOBENZOYL)-SS-ALANINE

b-Alanine, N-(4-aMinobenzoyl)-

N-(4-Aminobenzoyl)-

N-(4-Aminobenzoyl)-beta-alanine,98%

3-(4-Aminobenzamido)propionic Acid

N-(4-Aminobenzoyl)-beta-alanine - 25% aqueous solution

3-[[(4-aminophenyl)-oxomethyl]amino]propanoate

Balsalazide Impurity 5

Balsalazide Amino Impurity

N-(4-Aminobenzoyl)-β-alanine&gt

Balsalazide Impurity 2

N-(4-Aminobenzoyl)-β-alanine

N-(4-Aminobenzoyl)-beta-alanine USP/EP/BP

Balsalazide Aminobenzoyl

7377-08-4-

P-aminobenzoyl-beta-alanine

N-(4-Aminobenzoyl)-β-alanine, ≥ 98.0%

N-(4-Aminobenzoyl)-β-alanine, CAS 7377-08-4

7377-08-4

2000-65-1

7377-8-4

7737-08-4

H2NC6H4CONHCH2CH2CO2H

AMINE

BALSALAZIDE