METHYL 1-BENZYLPIPERIDINE-4-CARBOXYLATE

Uses

Product Name: METHYL 1-BENZYLPIPERIDINE-4-CARBOXYLATE
CAS No.: 10315-06-7
Chemical Name: METHYL 1-BENZYLPIPERIDINE-4-CARBOXYLATE
Synonyms: N-benzyl -4-Methyl piperidine;MethylN-benzylisonipecotinate;1-benzyl-4-piperidinecarboxylate;Methyl-benzylpiperidine-4-carboxylate;N-Benzylisonipecotic acid methyl ester;Methyl 1-benzyl-4-piperidinecarboxylate;METHYL 1-BENZYLPIPERIDINE-4-CARBOXYLATE;Methyl N-benzylpiperidine-4-carboxylate;1-Benzyl-4-piperidinecarboxylatemethylester;N-benzylpiperidine-4-carboxylate, methyl ester
CBNumber: CB51012067
Molecular Formula: C14H19NO2
Formula Weight: 233.31
MOL File: 10315-06-7.mol

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METHYL 1-BENZYLPIPERIDINE-4-CARBOXYLATE Property

Boiling point:: 115 °C
Density: 1.093±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 7.86±0.10(Predicted)
Appearance: Colorless to light yellow Liquid
InChI: InChI=1S/C14H19NO2/c1-17-14(16)13-7-9-15(10-8-13)11-12-5-3-2-4-6-12/h2-6,13H,7-11H2,1H3
InChIKey: MXOZSPRDEKPWCW-UHFFFAOYSA-N
SMILES: N1(CC2=CC=CC=C2)CCC(C(OC)=O)CC1
CAS DataBase Reference: 10315-06-7(CAS DataBase Reference)

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Safety

Risk Statements: 36/37/38
Safety Statements: 26-36
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: M332040
Product name: Methyl1-Benzylpiperidine-4-carboxylate
Packaging: 500mg
Price: $75
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0068335
Product name: METHYL 1-BENZYLPIPERIDINE-4-CARBOXYLATE
Purity: 95.00%
Packaging: 1G
Price: $707.02
Updated: 2021/12/16

Rieke Metals

Product number: NV02012
Product name: METHYL1-BENZYLPIPERIDINE-4-CARBOXYLATE
Packaging: 1g
Price: $809
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0068335
Product name: METHYL 1-BENZYLPIPERIDINE-4-CARBOXYLATE
Purity: 95.00%
Packaging: 2.5G
Price: $958.94
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0068335
Product name: METHYL 1-BENZYLPIPERIDINE-4-CARBOXYLATE
Purity: 95.00%
Packaging: 5G
Price: $1143.68
Updated: 2021/12/16

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METHYL 1-BENZYLPIPERIDINE-4-CARBOXYLATE Chemical Properties,Usage,Production

Uses

The preparation of donepezil hydrochloride using 1-benzyl-4-piperidinecarboxaldehyde as an intermediate has been widely studied and applied. Donepezil hydrochloride is a long-acting symptomatic treatment for Alzheimer's disease (AD).

Chemical Properties

Colorless liquid

Synthesis

2971-79-1

100-39-0

10315-06-7

Methyl 4-piperidinecarboxylate (10.00 g, 6.4 mmol) and triethylamine (10.32 g, 10.2 mmol) were dissolved in chloroform (100 mL), and benzyl bromide (14.69 g, 8.6 mmol) was slowly added under argon protection while the reaction mixture was cooled with water and an ice bath. The reaction mixture was stirred at room temperature overnight. After completion of the reaction, chloroform and water were added to separate the two phases. The aqueous phase was further extracted with chloroform. The organic phases were combined, dried over anhydrous sodium sulfate and concentrated to dryness under reduced pressure to give 13.80 g of methyl 1-benzyl-4-piperidinecarboxylate as an orange solid (yield: 88%).

References

[1] Arkivoc, 2010, vol. 2010, # 10, p. 132 - 148
[2] Patent: WO2004/76450, 2004, A1. Location in patent: Page 43-44
[3] Synthesis, 2002, # 7, p. 911 - 915
[4] Bioorganic and Medicinal Chemistry, 2016, vol. 24, # 18, p. 4324 - 4338

METHYL 1-BENZYLPIPERIDINE-4-CARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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METHYL 1-BENZYLPIPERIDINE-4-CARBOXYLATE Suppliers

China 158 Germany 2 India 4 United Kingdom 2 United States 14 Global 180

YuChen Biological Medicine

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View Lastest Price from METHYL 1-BENZYLPIPERIDINE-4-CARBOXYLATE manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: METHYL 1-BENZYLPIPERIDINE-4-CARBOXYLATE 10315-06-7
Price: US $6.00-4.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000kg
Release date: 2025-06-11

Shaanxi Dideu Medichem Co. Ltd

Product: METHYL 1-BENZYLPIPERIDINE-4-CARBOXYLATE 10315-06-7
Price: US $1.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10000KG
Release date: 2019-12-30

Wuhan Xinhao Biotechnology Co., Ltd

Product: METHYL 1-BENZYLPIPERIDINE-4-CARBOXYLATE 10315-06-7
Price: US $10.00-100.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000 Metric Ton/Month
Release date: 2024-03-20

10315-06-7, METHYL 1-BENZYLPIPERIDINE-4-CARBOXYLATERelated Search:

Ethyl 1-benzylpiperidine-4-carboxylate 1-BENZYL-3-OXO-PIPERIDINE-4-CARBOXYLIC ACID ETHYL ESTER Ethyl N-benzyl-3-oxo-4-piperidine-carboxylate hydrochloride METHYL1-BENZYL-PIPERIDINE-2-CARBOXYLATE METHYL 1-BENZYL-PIPERIDINE-3-CARBOXYLATE Methyl nicotinate Methyl isonicotinate 1-BENZYLPIPERIDINE Methyl isonipecotate ETHYL 1-(4-CHLOROBENZOYL)-4-PIPERIDINECARBOXYLATE Ethyl1-(4-Nitro-benzyl)-piperidine-4-carboxylate Ethyl1-(4-Bromo-benzyl)-piperidine-4-carboxylate ETHYL 1-(4-METHOXYBENZOYL)-4-PIPERIDINECARBOXYLATE 1-BENZOYL-PIPERIDINE-4-CARBOXYLIC ACID ETHYL ESTER ETHYL 1,4-DIBENZYLPIPERIDINE-4-CARBOXYLATE SALOR-INT L118583-1EA Ethyl 1-(3-Trifluoromethyl-benzyl)-piperidine-4- BUTTPARK 91\15-62

METHYL 1-BENZYLPIPERIDINE-4-CARBOXYLATE

MethylN-benzylisonipecotinate

Methyl 1-benzyl-4-piperidinecarboxylate

Methyl-benzylpiperidine-4-carboxylate

N-Benzylisonipecotic acid methyl ester

1-benzyl-4-piperidinecarboxylate

Methyl N-benzylpiperidine-4-carboxylate

1-Benzyl-piperidine-4-carboxylic acid Methyl ester

Methyl 1-benzylisonipecotate, 1-Benzyl-4-(methoxycarbonyl)piperidine

N-benzyl -4-Methyl piperidine

1-Benzyl-4-piperidinecarboxylic acid methyl ester

Methyl 1-benzylpiperidine-4-carboxylate CAS:10315-06-7

4-Piperidinecarboxylic acid, 1-(phenylmethyl)-, methyl ester

N-benzylpiperidine-4-carboxylate, methyl ester

1-Benzyl-4-piperidinecarboxylatemethylester

10315-06-7

Esters

Pyrans, Piperidines & Piperazines

Piperidine