(R)-(-)-1-Methyl-3-pyrrolidinol
- Product Name
- (R)-(-)-1-Methyl-3-pyrrolidinol
- CAS No.
- 104641-60-3
- Chemical Name
- (R)-(-)-1-Methyl-3-pyrrolidinol
- Synonyms
- (R)-1-METHYLPYRROLIDIN-3-OL;(R)-1-METHYL-3-PYRROLIDINOL;UNII:CGW2AL7PQ7;Glycopyrrolate Impurity 9;Glycopyrrolate Impurity 22;(R)-N-Methyl-3-pyrrolidinol;(3R)-1-Methylpyrrolidin-3-ol;(S)-3-Hydroxy-1-methylpyr...;(3R)-1-Methyl-3-pyrrolidinol;-(-)-1-Methyl-3-pyrrolidinol
- CBNumber
- CB5104299
- Molecular Formula
- C5H11NO
- Formula Weight
- 101.15
- MOL File
- 104641-60-3.mol
(R)-(-)-1-Methyl-3-pyrrolidinol Property
- Boiling point:
- 50-52 °C1 mm Hg(lit.)
- alpha
- -7 º (c=1%, chloroform)
- Density
- 0.921 g/mL at 25 °C(lit.)
- refractive index
- n20/D 1.4640(lit.)
- Flash point:
- 159 °F
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Liquid
- pka
- 14.95±0.20(Predicted)
- color
- Colorless to yellow to brown
- optical activity
- [α]20/D -7°, c = 1% in chloroform
- Sensitive
- Air Sensitive & Hygroscopic
- BRN
- 4349393
- InChIKey
- FLVFPAIGVBQGET-RXMQYKEDSA-N
- CAS DataBase Reference
- 104641-60-3(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H227Combustible liquid
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 647241
- Product name
- (R)-(?)-1-Methyl-3-pyrrolidinol
- Purity
- 97%
- Packaging
- 1g
- Price
- $134
- Updated
- 2023/06/20
- Product number
- M1937
- Product name
- (R)-1-Methyl-3-pyrrolidinol
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $92
- Updated
- 2025/07/31
- Product number
- M1937
- Product name
- (R)-1-Methyl-3-pyrrolidinol
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $315
- Updated
- 2025/07/31
- Product number
- M329030
- Product name
- (R)-1-Methyl-3-pyrrolidinol
- Packaging
- 250mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- AS35930
- Product name
- (R)-3-Hydroxy-1-methyl-pyrrolidine
- Purity
- 98+% ee
- Packaging
- 1g
- Price
- $58
- Updated
- 2021/12/16
(R)-(-)-1-Methyl-3-pyrrolidinol Chemical Properties,Usage,Production
Chemical Properties
Brown liquid
Uses
(R)-1-Methyl-3-pyrrolidinol is a useful synthetic intermediate. It is used for asymmetric synthesis of constrained (-)-S-adenosyl-L-homocysteine (SAH) analogs as DNA methyltransferase inhibitors.
Synthesis
50-00-0
40499-83-0
104641-60-3
In a 100 mL round bottom flask, 2 g of (R)-3-hydroxypyrrolidine, 25 mL of tetrahydrofuran (THF), 0.49 g of paraformaldehyde, and 1.5 g of 90% formic acid were added sequentially. The reaction mixture was stirred under reflux conditions for 5 h (until all solids were completely dissolved), after which the reaction system was cooled to 0 °C and the pH was adjusted to about 10 by slow addition of 10 mL of 10 N sodium hydroxide solution. the organic phase was separated and dried over anhydrous magnesium sulfate. After filtration to remove the desiccant, the solvent (THF) was removed by distillation under reduced pressure to afford the oily product (R)-1-methyl-3-hydroxypyrrolidine (1.5 g, 92% yield). The product was characterized by 1H NMR (CDCl3, 300 MHz): δ 1.50-1.60 (m, 1H), 1.98-2.10 (m, 1H), 2.25 (s, 3H), 2.25-2.40 (m, 2H), 2.50-2.60 (m, 1H), 2.61-2.70 (m, 1H), 3.80 (brs, 1H), and 4.20-4.30 (m, 1H).
References
[1] Patent: US2007/123557, 2007, A1. Location in patent: Page/Page column 16
[2] Patent: WO2003/87094, 2003, A2. Location in patent: Page/Page column 34
(R)-(-)-1-Methyl-3-pyrrolidinol Preparation Products And Raw materials
Raw materials
Preparation Products
(R)-(-)-1-Methyl-3-pyrrolidinol Suppliers
- Tel
- 320-37350700
- Fax
- +32 (0)37350701
- sales@tcieurope.eu
- Country
- Europe
- ProdList
- 23671
- Advantage
- 75
View Lastest Price from (R)-(-)-1-Methyl-3-pyrrolidinol manufacturers
- Product
- (R)-1-Methyl-3-pyrrolidinol 104641-60-3
- Price
- US $200.00-4000.00/KG
- Min. Order
- 100KG
- Purity
- no less than 98%
- Supply Ability
- 1MT per month
- Release date
- 2024-07-09
- Product
- (R)-(-)-1-Methyl-3-pyrrolidinol 104641-60-3
- Price
- US $90.00-900.00/kg
- Min. Order
- 10kg
- Purity
- 0.99
- Supply Ability
- 20tons
- Release date
- 2023-11-08
- Product
- (R)-(-)-1-Methyl-3-pyrrolidinol 104641-60-3
- Price
- US $8.80/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 100kg
- Release date
- 2019-08-05