ChemicalBook > CAS DataBase List > LEVCROMAKALIM

LEVCROMAKALIM

Product Name: LEVCROMAKALIM
CAS No.: 94535-50-9
Chemical Name: LEVCROMAKALIM
Synonyms: brl38227;lemakalim;Brn 3622889;levcromakelim;LEVCROMAKALIM;LevkroMakaliM;(3s-trans)-yrrolidinyl);Levcromakalim, 10 mM in DMSO;Levcromakalim, KATP channel activator;Potassium Channel,KcsA,Inhibitor,inhibit,BRL38227,BRL-38227,Levcromakalim
CBNumber: CB5104507
Molecular Formula: C16H18N2O3
Formula Weight: 286.33
MOL File: 94535-50-9.mol

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LEVCROMAKALIM Property

Melting point:: 242-244°
alpha: D26 -52.2° (c = 1 in chloroform)
Boiling point:: 482.3±45.0 °C(Predicted)
Density: 1.31±0.1 g/cm3(Predicted)
storage temp.: Store at RT
solubility: DMSO: ≤10 mM, soluble
form: solid
pka: 13.18±0.60(Predicted)
color: White to off-white

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Safety

Safety Statements: 22-24/25
WGK Germany: 3
RTECS: DJ2177500

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 1378
Product name: Levcromakalim
Purity: ≥99%(HPLC)
Packaging: 10
Price: $259
Updated: 2021/12/16

Tocris

Product number: 1378
Product name: Levcromakalim
Purity: ≥99%(HPLC)
Packaging: 50
Price: $1071
Updated: 2021/12/16

TRC

Product number: L331300
Product name: Levcromakalim
Packaging: 10mg
Price: $185
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0000895
Product name: LEVCROMAKALIM
Purity: 95.00%
Packaging: 10MG
Price: $216.3
Updated: 2021/12/16

ChemScene

Product number: CS-6950
Product name: Levcromakalim
Purity: 99.79%
Packaging: 5mg
Price: $132
Updated: 2021/12/16

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LEVCROMAKALIM Chemical Properties,Usage,Production

Uses

Anti-asthmatic; antihypertensive.

Uses

Levcromakalim is a potassium channel activator and vasorelaxant used in the management of hypertension in diabetes mellitus.

Definition

ChEBI: Levcromakalim is a 1-benzopyran.

Biological Activity

Active enantiomer of the prototypical K ATP channel opener cromakalim (trans-3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-2H-1-benzopyran-6-carbonitrile ). Hypotensive and airways relaxant. IC 50 = 490 nM in guinea pig trachea.

storage

Store at RT

LEVCROMAKALIM Preparation Products And Raw materials

Raw materials

Preparation Products

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94535-50-9, LEVCROMAKALIMRelated Search:

4-TERT-BUTOXYBENZONITRILE 3-(methylaminomethyl)benzonitrile LEVCROMAKALIM 3-M-TOLYL-DL-BETA-ALANINOL 3-CYANOBENZYLAMINE (S)-3-Dimethylamino-3-phenylpropanol 1-Benzyl-2-pyrrolidinone CROMAKALIM (S)-3-(1-Aminoethyl)benzonitrile 4-(2-hydroxyethoxy)benzonitrile 2-(3-CYANO-PHENYL)ETHANOL (2S)-(-)-1-AMINO-3-PHENOXY-2-PROPANOL 4-isopropoxybenzonitrile 1-(3-HYDROXYPROPYL)-2-PYRROLIDONE 3-PYRROLIDINO-1,2-PROPANEDIOL 1-(3-METHOXYPROPYL)-2-PYRROLIDINONE 6-METHYL-CHROMAN-4-YLAMINE HYDROCHLORIDE 4-[3-(Dimethylamino)propoxy]benzonitrile

(3S,4R)-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-4-(2-OXO-1-PYRROLIDINYL)-2H-1-BENZOPYRAN-6-CARBONITRILE

(3s-trans)-yrrolidinyl)

LEVCROMAKALIM

2h-1-benzopyran-6-carbonitrile,3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-p

brl38227

lemakalim

levcromakelim

(3S,4R)-3β-Hydroxy-4-(2-oxopyrrolizino)-2,2-dimethyl-3,4-dihydro-6-cyano-2H-1-benzopyran

(3β,4α)-3,4-Dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxopyrrolidin-1-yl)-2H-1-benzopyran-6-carbonitrile

(3β,4α)-3-Hydroxy-2,2-dimethyl-4-(2-oxopyrrolidin-1-yl)chroman-6-carbonitrile

2H-1-Benzopyran-6-carbonitrile, 3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-, (3S,trans)-

Brn 3622889

LevkroMakaliM

(3S,4R)-3-hydroxy-2,2-dimethyl-4-(2-oxopyrrolidin-1-yl)chroman-6-carbonitrile

2H-1-Benzopyran-6-carbonitrile, 3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-, (3S,4R)-

Potassium Channel,KcsA,Inhibitor,inhibit,BRL38227,BRL-38227,Levcromakalim

Levcromakalim, KATP channel activator

Levcromakalim, 10 mM in DMSO

94535-50-9

Ion Channels

Monovalent Ion Channels

Potassium Channel Modulators

Voltage-gated Ion Channels

Cell Signaling and Neuroscience

Cell Biology

BioChemical