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sorivudine

Product Name
sorivudine
CAS No.
77181-69-2
Chemical Name
sorivudine
Synonyms
YN-72;BvAraU;D01734;BV-araU;Bravavir;Brovavir;Sorivudin;sorivudine;Bravavir (tn);Sorivudine (jan/usan/inn)
CBNumber
CB51074625
Molecular Formula
C11H13BrN2O6
Formula Weight
349.13
MOL File
77181-69-2.mol
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sorivudine Property

Melting point:
182° (Sakata, 1980); mp 195-200° (dec) (Machida, Sakata, 1983)
alpha 
D25 +0.5° (1N NaOH)
Density 
1.979±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO: 250 mg/mL (716.07 mM)
form 
Solid
pka
8.37±0.10(Predicted)
color 
White to off-white
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Safety

Toxicity
LD50 in mice (mg/kg): ~3300 i.p.; >5000 s.c.; >10000 orally (Machida, Sakata, 1984)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
S677200
Product name
Sorivudine
Packaging
100mg
Price
$605
Updated
2021/12/16
ChemScene
Product number
CS-0080932
Product name
Sorivudine
Purity
95.03%
Packaging
50mg
Price
$700
Updated
2021/12/16
ChemScene
Product number
CS-0080932
Product name
Sorivudine
Purity
95.03%
Packaging
5mg
Price
$145
Updated
2021/12/16
ChemScene
Product number
CS-0080932
Product name
Sorivudine
Purity
95.03%
Packaging
10mg
Price
$230
Updated
2021/12/16
ChemScene
Product number
CS-0080932
Product name
Sorivudine
Purity
95.03%
Packaging
25mg
Price
$420
Updated
2021/12/16
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sorivudine Chemical Properties,Usage,Production

Description

Sorivudine is an orally-active antiviral nucleoside analog. It has potent and selective activity against herpes simplex virus type-1 (HSV-1) and varicella-zoster virus (VZV). In a cutaneous model infection of mice with HSV-1, oral administration of sorivudine at dose of 20 mg/kg resulted in a significant increase in the survival rate. Five percent sorivudine cream is also useful in the topical treatment of cutaneous HSV-1 infection, including immunocompromised patients. It has been suggested that its antiviral activity may be mediated by inhibition of DNA synthesis in virus infected cells.
Since the metabolite of sorivudine inhibits the enzyme for pyrimidine catabolism, caution should be taken not to use sorivudine in combination with fluorouracil drugs in order to avoid hematological disorders.

Originator

Yamasa Shoyu (Japan)

Uses

Sorivudine is an antimetabolite drug and can be used to synthesize antiviral compounds as well as compounds that can treat diseases of viral etiol.

Uses

Antiviral.

Definition

ChEBI: Sorivudine is an organic molecular entity.

brand name

Bravavir (Bristol-Myers Squibb);Usevir.

sorivudine Preparation Products And Raw materials

Raw materials

Preparation Products

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sorivudine Suppliers

China 22 Germany 1 India 1 United States 4 Global 28
Service Chemical Inc.
Tel
--
Fax
--
Email
sales@chemos-group.com
Country
Germany
ProdList
6350
Advantage
71

77181-69-2, sorivudineRelated Search:

Ketoconazole (E)-5-(2-BROMOVINYL)URACIL THYMINE-BETA-D-ARABINOFURANOSIDE Brivudine 5-vinyl-2'-deoxyuridine 1-beta-D-Arabinofuranosyluracil sorivudine

  • sorivudine
  • 1-(β-D-Arabinofuranosyl)-5-[(E)-2-bromoethenyl]uracil
  • 1-β-D-Arabinofuranosyl-5-[(E)-2-bromovinyl]-1,2,3,4-tetrahydropyrimidine-2,4-dione
  • Brovavir
  • BvAraU
  • BV-araU
  • YN-72
  • Bravavir
  • Bravavir (tn)
  • D01734
  • Sorivudine (jan/usan/inn)
  • 1-β-D-Arabinofuranosyl-5-[(1E)-2-bromoethenyl]-2,4(1H,3H)-pyrimidinedione
  • Sorivudin
  • 2,4(1H,3H)-Pyrimidinedione, 1-β-D-arabinofuranosyl-5-[(1E)-2-bromoethenyl]-
  • nucleoside,antiviral,inhibit,antimetabolite,Epstein-Barr,pyrimidine,virus,zoster,oral,varicella,Sorivudine,Inhibitor,herpes,DNA/RNA Synthesis,simplex,type
  • 1-β-D-Arabinofuranosyl-5-[(1E)-2-bromoethenyl]-2,4(1H,3H)-pyrimidinedione
  • 5-((E)-2-Bromovinyl)-1-((2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
  • 5-(E)-Bromovinyl-ara-uridine
  • 77181-69-2
  • C11H13BrN2O6