Fesoterodinefumarate

ChemicalBook > CAS DataBase List > Fesoterodinefumarate

Description Biological activity Side effects

Product Name: Fesoterodinefumarate
CAS No.: 286930-03-8
Chemical Name: Fesoterodinefumarate
Synonyms: Toviaz;CS-102;CS-244;SPM 907;Spm 8272;SMP 8272;Unii-eos72165S7;Fesoterodinefumarate;PF-00695838 fumarate;Fesoterodine maleate
CBNumber: CB51075581
Molecular Formula: C30H41NO7
Formula Weight: 527.65
MOL File: 286930-03-8.mol

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Fesoterodinefumarate Property

Melting point:: 72-78°C
storage temp.: Inert atmosphere,2-8°C
solubility: DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly)
form: Solid
color: White to Off-White
Stability:: Hygroscopic

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

H361Suspected of damaging fertility or the unborn child

H402Harmful to aquatic life

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P281Use personal protective equipment as required.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 23777
Product name: Fesoterodine (fumarate)
Purity: ≥98%
Packaging: 1mg
Price: $29
Updated: 2024/03/01

Cayman Chemical

Product number: 23777
Product name: Fesoterodine (fumarate)
Purity: ≥98%
Packaging: 5mg
Price: $72
Updated: 2024/03/01

Cayman Chemical

Product number: 23777
Product name: Fesoterodine (fumarate)
Purity: ≥98%
Packaging: 10mg
Price: $99
Updated: 2024/03/01

TRC

Product number: F321300
Product name: (R)-FesoterodineFumarate
Packaging: 25mg
Price: $145
Updated: 2021/12/16

TRC

Product number: F321300
Product name: (R)-FesoterodineFumarate
Packaging: 50mg
Price: $275
Updated: 2021/12/16

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Fesoterodinefumarate Chemical Properties,Usage,Production

Description

Fesoterodine fumarate is a new drug for the treatment of overactive bladder syndrome developed by Pfizer, which was approved by the US FDA in October 2008. Fesoterodine fumarate is a prodrug, which is rapidly hydrolyzed in blood after oral administration to 5-hydroxymethyl tolterodine (5-HMT), which is also the active metabolite of tolterodine.

Biological activity

Fesoterodine Fumarate (SPM 907) is a prodrug of the muscarinic receptor antagonist 5-hydroxymethyl tolterodine, used to treat overactive bladder.

Side effects

The most common side effects was dry mouth, which was observed in the placebo group, the product 4 in the Phase II and Phase III clinical trials (a total of 2 859 patients, 2 288 taking this product for 8 to 12 weeks). The incidences of dry mouth at mg/d and 8 mg/d were 7%, 19%, and 35%, respectively, and the incidences of drug discontinuation due to dry mouth were 0.4%, 0.4%, and 0.8%, respectively. The second most common adverse reaction was constipation. The incidence of constipation in the placebo group and the 4 mg/d and 8 mg/d groups of this product was 2%, 4% and 6%, respectively. Other reported adverse events included loss of appetite, nausea, epigastric pain, urinary tract infection, upper respiratory tract infection, dry eyes, dysuria, urinary retention, cough, peripheral edema, back pain, insomnia, abnormal liver function, and rash.

Chemical Properties

White Solid

Uses

Fesoterodine fumarate (Toviaz) is an antimuscarinic agent and is rapidly de-esterified to its active metabolite 5-hydroxymethyl tolterodine that is a muscarinic receptor antagonist. Fesoterodine fumarate (Toviaz) is used to treat the symptoms of overactiv

Uses

(R)-Fesoterodine Fumarate is a muscarinic receptor antagonist for the treatment of Lower Urininary Tract Symptoms (LUTS). It is very similar to Tolterodine (T535800).

Clinical Use

Antimuscarinic:
Symptomatic treatment of urinary incontinence, frequency or urgency

Drug interactions

Potentially hazardous interactions with other drugs
Anti-arrhythmics: increased risk of antimuscarinic side effects with disopyramide.
Antifungals: dose reduction advised with itraconazole and ketoconazole.
Antivirals: dose reduction advised with atazanavir, indinavir, ritonavir and saquinavir.
Induction of CYP3A4 may lead to subtherapeutic plasma levels. Concomitant use with CYP3A4 inducers (e.g. carbamazepine, rifampicin, phenobarbital, phenytoin, St John's Wort) is not recommended.
Co-administration of a potent CYP2D6 inhibitor may result in increased exposure and adverse events. A dose reduction to 4 mg may be needed'

Metabolism

Rapidly and extensively hydrolysed to its active metabolite. The active metabolite is further metabolised in the liver to its carboxy, carboxy-N-desisopropyl, and N-desisopropyl metabolites via two major pathways involving CYP2D6 and CYP3A4. None of these metabolites contribute significantly to the antimuscarinic activity of fesoterodine. Approximately 70% of an oral dose of fesoterodine is recovered in the urine as metabolites, and a smaller amount in the faeces.

Fesoterodinefumarate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Fesoterodinefumarate manufacturers

Henan Fengda Chemical Co., Ltd

Product: Fesoterodinefumarate 286930-03-8
Price: US $5.00-0.10/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-16

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Fesoterodinefumarate 286930-03-8
Price: US $0.00/g
Min. Order: 1g
Purity: 99%~101%
Supply Ability: 10kg/month
Release date: 2021-07-28

Henan Bao Enluo International TradeCo.，LTD

Product: Fesoterodinefumarate 286930-03-8
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000tons
Release date: 2023-08-22

286930-03-8, FesoterodinefumarateRelated Search:

(R)-5-HydroxyMethyl Tolterodine ForMate REMODULIN (1R,2S)-rel-2-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide hydrochloride FESOTERODINE Rivaroxaban Thaumatin Fenofibrate Anidulafungin Dimethyl fumarate Fumaric acid Entacapone Fesoterodinefumarate Levetiracetam Betahistine Lamotrigine Ferrous fumarate Pregabalin Tolterodine tartrate

Fesoterodine maleate

2-[(1R)-3-[Bis(1-methylethyl)amino]-1-phenylpropyl]-4-(hydroxymethyl)phenyl 2-methylpropanoate fumarate

Propanoic acid, 2-methyl-, 2-((1R)-3-(bis(1-methylethyl)amino)-1-phenylpropyl)-4-(hydroxymethyl)phenyl ester, (2E)-2-butenedioate (1:1) (salt)

Spm 8272

Toviaz

Unii-eos72165S7

Fesoterodinefumarate

(R)-Fesoterodine Fumarate

2-Methylpropanoic Acid 2-[(1R)-3-[Bis(1-methylethyl)amino]-1-phenylpropyl]-4-(hydroxymethyl)phenyl Ester (2E)-2-Butenedioate

SMP 8272

SPM 907

FESOTERODINE MALEATE INTERMEDIATES

Fesoterodine fuMarate (Toviaz)

2-((1R)-3-(Diisopropylamino)-1-phenylpropyl)-4(hydroxymethyl)phenyl isobutyrate

Fesoterodine fuMarate salt

PF-00695838 fumarate

(R)-2-(3-(diisopropylamino)-1-phenylpropyl)-4-(hydroxymethyl)phenyl isobutyrate fumarate

(R)-Fesoterodine fumarate 2-[(1R)-3-[Bis(1-methylethyl)amino]-1-phenylpropyl]-4-(hydroxymethyl)phenyl 2-methylpropanoate fumarate

(R)-2-(3-(Diisopropylamino)-1-phenylpropyl)-4-methoxyphenyl isobutyrate fumarate

[2-[(1R)-3-(Di(propan-2-yl)amino)-1-phenylpropyl]-4-(hydroxymethyl)phenyl] 2-methylpropanoate fumarate

Fesoterodine-fumarlate-d7

Fesoterodine maleate （Toviaz）

CS-102

CS-244

Fesoterodinefumarate USP/EP/BP

Fesoterodine fumarateQ: What is Fesoterodine fumarate Q: What is the CAS Number of Fesoterodine fumarate Q: What is the storage condition of Fesoterodine fumarate

TIANFUCHEM--Fesoterodinefumarate

2-[(1R)-3-(diisopropylamino)-1-phenyl-propyl]-4-(hydroxymethyl)phenyl] 2-methylpropanoate

286930-03-8

C26H37NO3C4H4O4

C30H41NO7

Toviaz

Amines

Aromatics

Intermediates & Fine Chemicals

Pharmaceuticals

Aromatics Compounds