Bavituximab

Product Name: Bavituximab
CAS No.: 648904-28-3
Chemical Name: Bavituximab
Synonyms: Tarvacin;BAVITUXIMAB;Anti-PS MAb 3G4;Research Grade Bavituximab;Research Grade Bavituximab (DGK10101)
CBNumber: CB51090946
Formula Weight: 0
MOL File: Mol file

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Bavituximab Property

form: Liquid
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: ATB0010207
Product name: BAVITUXIMAB
Purity: 98.00%
Packaging: 5MG
Price: $495.07
Updated: 2021/12/16

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Bavituximab Chemical Properties,Usage,Production

Uses

Bavituximab (Anti-Human Phosphatidylserine Recombinant Antibody) is a phosphatidylserine (PS)-targeting monoclonal antibody, suppresses tumor growth by targeting tumor vasculature and reactivating antitumor immunity. Bavituximab plus Paclitaxel.html" class="link-product" target="_blank">Paclitaxel (HY-B0015) and Carboplatin.html" class="link-product" target="_blank">Carboplatin (HY-17393), have enhanced inhibition on non-small-cell lung cancer[1].

in vivo

Sorafenib induces exposure of anionic phospholipids in tumor model in mice. Bavituximab (100 μg/mouse; i.v.; single dose; 48 h after Sorafenib treatment) traces phosphatidylserine exposure in vivo^[2].

Animal Model:	Mice bearing subcutaneous PLC/PRF/5, C3A, and Huh7 tumors^[2]
Dosage:	100 μg/mouse (Bavituximab/β2GP1)
Administration:	Intravenous injection single dose; 48 h after sorafenib treatment (100 mg/kg; p.o.; single dose)
Result:	Traced phosphatidylserine exposure in vivo in mice with tumors.

References

[1] Digumarti R, et al. Bavituximab plus paclitaxel and carboplatin for the treatment of advanced non-small-cell lung cancer. Lung Cancer. 2014 Nov;86(2):231-6. DOI:10.1016/j.lungcan.2014.08.010
[2] Cheng X, et al. Antibody-Mediated Blockade of Phosphatidylserine Enhances the Antitumor Effect of Sorafenib in Hepatocellular Carcinomas Xenografts. Ann Surg Oncol. 2016 Dec;23(Suppl 5):583-591. DOI:10.1245/s10434-016-5107-5

Bavituximab Preparation Products And Raw materials

Raw materials

Preparation Products

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Bavituximab Suppliers

China 21 United States 5 Global 26

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648904-28-3, BavituximabRelated Search:

Unii-9927mt646m Infliximab CETUXIMAB Rituximab Rituximab Bavituximab Actoxumab Racotumomab Polatuzumab vedotin Solanezumab

BAVITUXIMAB

Tarvacin

Research Grade Bavituximab (DGK10101)

Anti-PS MAb 3G4

Research Grade Bavituximab

648904-28-3