AC-RIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNS-NH2
- Product Name
- AC-RIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNS-NH2
- CAS No.
- 475221-20-6
- Chemical Name
- AC-RIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNS-NH2
- Synonyms
- NEP1-40;NOGO-66 (1-40);PubChem ID: 90488731;Nogo Extracellular Peptide;M.W. 4625.11 C206H324N56O65;NOGO EXTRACELLULAR PEPTIDE, 1-40;NOGO-66 (1-40) ANTAGONIST PEPTIDE;NEP1-40; NOGO EXTRACELLULAR PEPTIDE; 1-40;AC-RIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNS-NH2;ARG-ILE-TYR-LYS-GLY-VAL-ILE-GLN-ALA-ILE-GLN-LYS-SER-ASP-GLU-GLY-HIS-PRO-PHE-ARG-ALA-TYR-LEU-GLU-SER-GLU-VAL-ALA-ILE-SER-GLU-GLU-LEU-VAL-GLN-LYS-TYR-SER-ASN-SER-NH2
- CBNumber
- CB5110481
- Molecular Formula
- C206H324N56O65
- Formula Weight
- 4625.11
- MOL File
- 475221-20-6.mol
AC-RIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNS-NH2 Property
- storage temp.
- -20°C
- solubility
- H2O: 1 mg/mL
- form
- solid
- color
- white
- Water Solubility
- Soluble to 1 mg/ml in water
Safety
- Safety Statements
- 22-24/25
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- N7161
- Product name
- Nogo-66(1-40) antagonist peptide
- Purity
- ≥84% (HPLC)
- Packaging
- 1mg
- Price
- $231.2
- Updated
- 2024/03/01
- Product number
- 1984
- Product name
- Nogo-66(1-40)
- Packaging
- 1
- Price
- $374
- Updated
- 2021/12/16
- Product number
- B5247
- Product name
- Nogo-66(1-40)
- Packaging
- 1mg
- Price
- $549
- Updated
- 2021/12/16
- Product number
- PEP0003973
- Product name
- NOGO-66(1-40) ANTAGONIST PEPTIDE
- Purity
- 95.00%
- Packaging
- 1MG
- Price
- $859.85
- Updated
- 2021/12/16
AC-RIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNS-NH2 Chemical Properties,Usage,Production
Uses
Nogo-66(1-40) antagonist peptide has been used as a Nogo-66 receptor antagonist peptide:
- to study the preliminary therapeutic effect after inhibition of Nogo-A in the cauda equina compression (CEC) model
- to determine the effects of Nogo-A/NgR1 on autophagic activation
- to study its role in Nogo-B mediated axonal branching using Schwann cells and sensory neurons of mice
Biochem/physiol Actions
Myelin-derived axon outgrowth inhibitors, such as Nogo, may account for the lack of axonal regeneration in the central nervous system (CNS) after trauma in adult mammals. Nogo-66 can inhibit axonal outgrowth through an axonal Nogo-66 receptor (NgR). Competitive antagonists of NgR derived from amino-terminal peptide fragments of Nogo-66. The Nogo-66(1 40) antagonist peptide (NEP1 40) blocks Nogo-66 or CNS myelin inhibition of axonal outgrowth in vitro, demonstrating that NgR mediates a significant portion of axonal outgrowth inhibition by myelin. Intrathecal administration of NEP1 40 to rats with mid-thoracic spinal cord hemisection results in significant axon growth of the corticospinal tract, and improves functional recovery. Thus, Nogo-66 and NgR have central roles in limiting axonal regeneration after CNS injury, and NEP1-40 provides a potential therapeutic agent.
storage
Store at -20°C