(R)-4-BOC-1-CBZ-2-HYDROXYMETHYLPIPERAZINE
- Product Name
- (R)-4-BOC-1-CBZ-2-HYDROXYMETHYLPIPERAZINE
- CAS No.
- 930782-89-1
- Chemical Name
- (R)-4-BOC-1-CBZ-2-HYDROXYMETHYLPIPERAZINE
- Synonyms
- (R)-4-BOC-1-CBZ-2-HYDROXYMETHYLPIPERAZINE;(R)-1-Boc-4-Cbz-2-(hydroxymethyl)piperazine;(R)-4-Benzyl 1-tert-butyl 2-(hydroxyMethyl)piperazine-1,4-dicarboxylate;4-O-benzyl 1-O-tert-butyl (2R)-2-(hydroxymethyl)piperazine-1,4-dicarboxylate;Benzyl 1-((tert-butoxy)carbonyl)-(2R)-2-(hydroxymethyl)piperazine-4-carboxylate;(R)-2-Hydroxymethyl-piperazine-1,4-dicarboxylic acid 1-benzyl ester 4-tert-butyl ester;1,4-Piperazinedicarboxylic acid, 2-(hydroxymethyl)-, 1-(1,1-dimethylethyl) 4-(phenylmethyl) ester, (2R)-
- CBNumber
- CB51118699
- Molecular Formula
- C18H26N2O5
- Formula Weight
- 350.41
- MOL File
- Mol file
(R)-4-BOC-1-CBZ-2-HYDROXYMETHYLPIPERAZINE Property
- Boiling point:
- 480.5±30.0 °C(Predicted)
- Density
- 1?+-.0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 14.97±0.10(Predicted)
- Appearance
- Colorless to off-white Viscous liquid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CCH0003499
- Product name
- (R)-4-BOC-1-CBZ-2-HYDROXYMETHYLPIPERAZINE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $269.85
- Updated
- 2021/12/16
- Product number
- Z2817
- Product name
- 4-Benzyl1-tert-butyl(2R)-2-(hydroxymethyl)piperazine-1,4-dicarboxylate
- Packaging
- 5g
- Price
- $532
- Updated
- 2021/12/16
- Product number
- CM277862
- Product name
- (R)-4-Benzyl1-tert-butyl2-(hydroxymethyl)piperazine-1,4-dicarboxylate
- Purity
- 95+%
- Packaging
- 5g
- Price
- $398
- Updated
- 2021/12/16
- Product number
- 930782891
- Product name
- (R)-4-Benzyl1-tert-butyl2-(hydroxymethyl)piperazine-1,4-dicarboxylate
- Packaging
- 5g
- Price
- $400
- Updated
- 2021/12/16
- Product number
- CD11010990
- Product name
- (R)-4-Benzyl1-tert-butyl2-(hydroxymethyl)piperazine-1,4-dicarboxylate
- Purity
- 97%
- Packaging
- 5g
- Price
- $422
- Updated
- 2021/12/16
(R)-4-BOC-1-CBZ-2-HYDROXYMETHYLPIPERAZINE Chemical Properties,Usage,Production
Synthesis
138775-02-7
930782-89-1
General procedure for the synthesis of R-4-Boc-1-Cbz-2-hydroxymethylpiperazine from (R)-N-1-Boc-N-4-Cbz-2-piperazinecarboxylic acid: (2R)-4-[(phenylmethoxy)carbonyl]-1-(tert-butoxycarbonyl)piperazine-2-carboxylic acid (1.4 g, 3.9 mmol) was dissolved in dimethoxyethane (10 mL), cooled, and N-methylmorpholine (0.4 g, 3.9 mmol) was added dropwise to the solution. N-methylmorpholine (0.4 g, 3.9 mmol) was added dropwise to the solution, followed by isobutyl chloroformate (0.54 g, 3.9 mmol). The reaction mixture was stirred at 0 °C for 20 min and then filtered. The filtrate was transferred to a 500 mL flask and cooled again. Sodium borohydride (0.22 g, 5.9 mmol) dissolved in water (5 mL) was added to the cooled filtrate and the external cooling bath was removed. The reaction mixture was stirred until its temperature rose to room temperature, then water (120 mL) was added. The mixture was extracted three times with ethyl acetate, the organic phases were combined, dried and the solvent evaporated. The product was purified by silica gel column chromatography (eluent: ethyl acetate/heptane, 10% to 70% gradient elution) to afford 1.2 g (84% yield) of 4-benzyl 1-tert-butyl (2R)-2-(hydroxymethyl)piperazine-1,4-dicarboxylate as a colorless oil.1H NMR (500 MHz, CDCl3): δ 1.4 (s, 9H), 2.7-3.2 (b , 4H), 3.5 (b, 2H), 3.8-4.2 (m, 4H), 5.1 (m, 2H), 7.2-7.4 (m, 5H); LCMS: m/z 349 (M-1).
References
[1] Patent: WO2007/37743, 2007, A1. Location in patent: Page/Page column 47
(R)-4-BOC-1-CBZ-2-HYDROXYMETHYLPIPERAZINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from (R)-4-BOC-1-CBZ-2-HYDROXYMETHYLPIPERAZINE manufacturers
- Product
- (R)-4-Benzyl 1-tert-butyl 2-(hydroxymethyl)piperazine-1,4-dicarboxylate 930782-89-1
- Price
- US $2.00-6.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-07-29
- Product
- (R)-4-BOC-1-CBZ-2-HYDROXYMETHYLPIPERAZINE 930782-89-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 97%-99.9%
- Supply Ability
- 100kg
- Release date
- 2019-12-23
- Product
- (R)-4-BOC-1-CBZ-2-HYDROXYMETHYLPIPERAZINE 930782-89-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 97%-99.9%
- Supply Ability
- 100kg
- Release date
- 2019-12-23