ChemicalBook > CAS DataBase List > 4-P-AMINOPHENYL-1-BOC-PIPERIDINE

4-P-AMINOPHENYL-1-BOC-PIPERIDINE

Product Name
4-P-AMINOPHENYL-1-BOC-PIPERIDINE
CAS No.
170011-57-1
Chemical Name
4-P-AMINOPHENYL-1-BOC-PIPERIDINE
Synonyms
4-(1-Boc-4-piperidyl)aniline;1-N-Boc-(4-aminophenyl)piperidine;4-P-AMINOPHENYL-1-BOC-PIPERIDINE;4-(1-Boc-piperidin-4-yl)-phenylami;4-(1-Boc-piperidin-4-yl)-phenylamine, 98%;1-(tert-Butoxycarbonyl)-4-(4-aminophenyl)piperidine;tert-butyl 4-(4-aminophenyl)piperidin-1-carboxylate;tert-Butyl 4-(4-aminophenyl)-1-piperidinecarboxylate;4-(4-Aminophenyl)piperidin-1-carboxylic acid tert-butyl ester;4-(4-Aminophenyl)piperidine-1-carboxylic acid tert-butyl ester
CBNumber
CB51119429
Molecular Formula
C16H24N2O2
Formula Weight
276.37
MOL File
170011-57-1.mol
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4-P-AMINOPHENYL-1-BOC-PIPERIDINE Property

Melting point:
119 °C
Boiling point:
412.7±45.0 °C(Predicted)
Density 
1.100±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
form 
powder to crystal
pka
4.97±0.10(Predicted)
color 
White to Yellow to Green
InChI
InChI=1S/C16H24N2O2/c1-16(2,3)20-15(19)18-10-8-13(9-11-18)12-4-6-14(17)7-5-12/h4-7,13H,8-11,17H2,1-3H3
InChIKey
YRLQFRXDWBFGMK-UHFFFAOYSA-N
SMILES
N1(C(OC(C)(C)C)=O)CCC(C2=CC=C(N)C=C2)CC1
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Safety

HS Code 
2933599590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TCI Chemical
Product number
B5832
Product name
tert-Butyl 4-(4-Aminophenyl)piperidine-1-carboxylate
Purity
>97.0%(HPLC)
Packaging
200mg
Price
$17
Updated
2025/07/31
TCI Chemical
Product number
B5832
Product name
tert-Butyl 4-(4-Aminophenyl)piperidine-1-carboxylate
Purity
>97.0%(HPLC)
Packaging
1g
Price
$65
Updated
2025/07/31
TRC
Product number
B621100
Product name
1-Boc-4-(4-aminophenyl)piperidine
Packaging
1g
Price
$195
Updated
2021/12/16
Apolloscientific
Product number
OR322231
Product name
1-Boc-4-(4-aminophenyl)-piperidine
Packaging
100mg
Price
$143
Updated
2021/12/16
Matrix Scientific
Product number
074073
Product name
1-Boc-4-(4-Aminophenyl)piperidine
Purity
95+%
Packaging
1g
Price
$121
Updated
2021/12/16
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4-P-AMINOPHENYL-1-BOC-PIPERIDINE Chemical Properties,Usage,Production

Uses

1-Boc-4-(4-aminophenyl)piperidine is a useful synthetic intermediate used in the synthesis of FMS inhibitors that may be useful in treating rheumatoid arthritis and other chronic inflammatory diseases.

Synthesis

873454-43-4

170011-57-1

General procedure for the synthesis of tert-butyl 4-(4-aminophenyl)piperidine-1-carboxylate from tert-butyl 4-(4-aminophenyl)-5,6-dihydropyridine-1(2H)-carboxylate: 4-(4-aminophenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester (0.35 g, 1.2 mmol) (prepared in previous step) was dissolved in methanol and added to a 10% Pd/C catalyst and hydrogenated at 20 psi hydrogen pressure for 1 hour. Upon completion of the reaction, the reaction solution was filtered to remove the catalyst and the filtrate was concentrated to give 0.35 g (100% yield) of tert-butyl 4-(4-aminophenyl)piperidine-1-carboxylate as a yellow solid. Mass spectrum (ESI, m/z): the calculated value of [M+H]+ for C16H24N2O2 was 277.2 and the measured value was 277.1.

References

[1] Patent: WO2006/47277, 2006, A2. Location in patent: Page/Page column 58-59
[2] Patent: US2006/281788, 2006, A1. Location in patent: Page/Page column 55
[3] Patent: US2008/51402, 2008, A1. Location in patent: Page/Page column 41
[4] Patent: US2008/114007, 2008, A1. Location in patent: Page/Page column 90
[5] Patent: US2007/60577, 2007, A1. Location in patent: Page/Page column 53

4-P-AMINOPHENYL-1-BOC-PIPERIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-P-AMINOPHENYL-1-BOC-PIPERIDINE Suppliers

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View Lastest Price from 4-P-AMINOPHENYL-1-BOC-PIPERIDINE manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
1-BOC-4-(4-AMINOPHENYL)PIPERIDINE 170011-57-1
Price
US $1.10-9.90/KG
Min. Order
1KG
Purity
99% min
Supply Ability
100kg
Release date
2025-08-18
Career Henan Chemical Co
Product
4-P-AMINOPHENYL-1-BOC-PIPERIDINE 170011-57-1
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2019-12-23

170011-57-1, 4-P-AMINOPHENYL-1-BOC-PIPERIDINE Related Search:

tert-butyl 4-(4-(2-aminoethyl)phenyl)piperidine-1-carboxylate tert-butyl 4-(4-(aminomethyl)phenyl)piperidine-1-carboxylate hydrochloride TERT-BUTYL 4-(4-(AMINOMETHYL)PHENYL)PIPERIDINE-1-CARBOXYLATE tert-butyl 4-(4-(hydroxymethyl)phenyl)piperidine-1-carboxylate tert-butyl 4-(4-(2-hydroxyethyl)phenyl)piperidine-1-carboxylate 4-(4-Aminophenyl)piperazine-1-carboxylic acid tert-butyl ester 1-Boc-piperidine 1-Boc-3-(3-Aminophenyl)Piperidine 1-Boc-3-(4-Aminophenyl)Piperidine 3-(4-AMINO-PHENYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 1-Boc-4-(3-Aminophenyl)Piperidine 1-Boc-3-(2-Aminophenyl)Piperidine 1-Boc-4-(2-Aminophenyl)Piperidine 4-(4-AMINOPHENYL)-PIPERIDINE 4-(1-METHYL-PIPERIDIN-4-YL)-ANILINE 4-P-AMINOPHENYL-1-BOC-PIPERIDINE

  • 4-P-AMINOPHENYL-1-BOC-PIPERIDINE
  • 1-N-Boc-(4-aminophenyl)piperidine
  • 4-(4-Aminophenyl)piperidine-1-carboxylic acid tert-butyl ester
  • 1-Piperidinecarboxylicacid,4-(4-aMinophenyl)-,1,1-diMethylethylester
  • 4-(1-Boc-piperidin-4-yl)-phenylamine, 98%
  • tert-Butyl 4-(4-aminophenyl)-1-piperidinecarboxylate
  • 4-(4-aminophenyl)-1-piperidinecarboxylic acid tert-butyl ester
  • 1-(tert-Butoxycarbonyl)-4-(4-aminophenyl)piperidine
  • 4-(1-Boc-piperidin-4-yl)-phenylami
  • 4-(1-Boc-4-piperidyl)aniline
  • tert-butyl 4-(4-aminophenyl)piperidin-1-carboxylate
  • 4-(4-Aminophenyl)piperidin-1-carboxylic acid tert-butyl ester
  • 170011-57-1