4-(4-Aminophenyl)piperazine-1-carboxylic acid tert-butyl ester

Product Name: 4-(4-Aminophenyl)piperazine-1-carboxylic acid tert-butyl ester
CAS No.: 170911-92-9
Chemical Name: 4-(4-Aminophenyl)piperazine-1-carboxylic acid tert-butyl ester
Synonyms: Itraconazole Impurity 54;4-(4-Boc-piperazin-1-yl)aniline;1-BOC-4-(4'-AMINOPHENYL)PIPERAZINE;4-(4-Aminophenyl)piperazine, N1-BOC protected;4-(4-aminophenyl)-1-t-butyloxycarbonylpiperazine;4-(4-Aminophenyl)piperazine, N1-BOC protected 98%;t-Butyl 4-(4-aminophenyl)piperazine-1-carboxylate;TERT-BUTYL 4-(4-AMINOPHENYL)PIPERAZINE-1-CARBOXYLATE;4-(4-AMINOPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;4-(4-Aminophenyl)piperazine-1-carboxylic acid tert-butyl est...
CBNumber: CB9726019
Molecular Formula: C15H23N3O2
Formula Weight: 277.36
MOL File: 170911-92-9.mol

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4-(4-Aminophenyl)piperazine-1-carboxylic acid tert-butyl ester Property

Boiling point:: 441.1±40.0 °C(Predicted)
Density: 1.145±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
pka: 7.69±0.10(Predicted)
form: Solid
Appearance: Brown to reddish brown Solid
Water Solubility: Slightly soluble in water.
InChI: InChI=1S/C15H23N3O2/c1-15(2,3)20-14(19)18-10-8-17(9-11-18)13-6-4-12(16)5-7-13/h4-7H,8-11,16H2,1-3H3
InChIKey: RXFHRKPNLPBDGE-UHFFFAOYSA-N
SMILES: N1(C(OC(C)(C)C)=O)CCN(C2=CC=C(N)C=C2)CC1

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Safety

HS Code: 2921420090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: A3499
Product name: tert-Butyl 4-(4-Aminophenyl)piperazine-1-carboxylate
Packaging: 5G
Price: $63
Updated: 2025/07/31

TCI Chemical

Product number: A3499
Product name: tert-Butyl 4-(4-Aminophenyl)piperazine-1-carboxylate
Packaging: 25G
Price: $190
Updated: 2025/07/31

TRC

Product number: B621140
Product name: 1-Boc-4-(4-aminophenyl)piperazine
Packaging: 5g
Price: $330
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA56975
Product name: 4-(4-Aminophenyl)piperazine-1-carboxylic acid tert-butyl ester
Packaging: 25g
Price: $340
Updated: 2021/12/16

Chem-Impex

Product number: 24311
Product name: 4-(4-Aminophenyl)piperazine-1-carboxylicacidtert-butylester,97%(HPLC)
Purity: 97%(HPLC)
Packaging: 5G
Price: $156.8
Updated: 2021/12/16

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4-(4-Aminophenyl)piperazine-1-carboxylic acid tert-butyl ester Chemical Properties,Usage,Production

Uses

1-Boc-4-(4-aminophenyl)piperazine is a important organic intermediate. It can be used in agrochemical, pharmaceutical and dyestuff.

Synthesis

182618-86-6

170911-92-9

The general procedure for the synthesis of tert-butyl 4-(4-aminophenyl)piperazine-1-carboxylate from tert-butyl 4-(4-nitrophenyl)piperazine-1-carboxylate was as follows: first, tert-butyl 4-(4-nitrophenyl)piperazine-1-carboxylate (8.2 g, 26.68 mmol) was dissolved in methanol (100 mL), followed by purging with nitrogen and depressurization. Next, 10% wet palladium carbon catalyst was added to the solution and the hydrogenation reaction was carried out under hydrogen pressure of 50 psi for 16 hours. Upon completion of the reaction, the mixture was filtered through diatomaceous earth to remove the catalyst, and the filtrate was subsequently concentrated under reduced pressure to afford tert-butyl 4-(4-aminophenyl)piperazine-1-carboxylate (7.4 g, 97% yield) as a dark blue oily product, which was used directly in subsequent reactions without further purification. The molecular formula of the product was C15H23N3O2, and the mass spectrometry analysis showed that the m/z was 277.9 (M + H).

References

[1] Patent: WO2006/38039, 2006, A1. Location in patent: Page/Page column 17; 30
[2] Patent: EP1215208, 2002, A2. Location in patent: Example C(101)
[3] Patent: WO2012/110773, 2012, A1. Location in patent: Page/Page column 52; 53
[4] Patent: WO2014/26242, 2014, A1. Location in patent: Page/Page column 77
[5] Patent: WO2014/27199, 2014, A1. Location in patent: Page/Page column 55

4-(4-Aminophenyl)piperazine-1-carboxylic acid tert-butyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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4-(4-Aminophenyl)piperazine-1-carboxylic acid tert-butyl ester Suppliers

China 140 India 3 United Kingdom 3 United States 15 Global 161

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View Lastest Price from 4-(4-Aminophenyl)piperazine-1-carboxylic acid tert-butyl ester manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: 1-Piperazinecarboxylic acid, 4-(4-aMinophenyl)-, 1,1-diMethylethyl ester 170911-92-9
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

Career Henan Chemical Co

Product: 4-(4-Aminophenyl)piperazine-1-carboxylic acid tert-butyl ester 170911-92-9
Price: US $6.68/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 1kg-1000kg
Release date: 2020-01-10

Career Henan Chemical Co

Product: 4-(4-Aminophenyl)piperazine-1-carboxylic acid tert-butyl ester 170911-92-9
Price: US $6.68/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 1kg-1000kg
Release date: 2020-01-10

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1-Piperazinecarboxylic acid, 4-(4-aminophenyl)-, 1,1-dimethylethyl ester

4-(4-Aminophenyl)piperazine, N1-BOC protected

t-Butyl 4-(4-aminophenyl)piperazine-1-carboxylate

4-(4-Aminophenyl)piperazine, N1-BOC protected 98%

4-(4-Aminophenyl)piperazine-1-carboxylic acid tert-butyl est...

Itraconazole Impurity 54

4-(4-aminophenyl)-1-t-butyloxycarbonylpiperazine

170911-92-9

179011-92-9