2-Hydroxy-5-methylpyridine
- Product Name
- 2-Hydroxy-5-methylpyridine
- CAS No.
- 1003-68-5
- Chemical Name
- 2-Hydroxy-5-methylpyridine
- Synonyms
- 5-Methylpyridin-2(1H)-one;2(1H)-Pyridinone, 5-methyl-;5-methyl-2-pyridone;2-HYDROXY-5-PICOLINE;AKOS BBS-00002970;2-Hydroxy-5-methyL;5-METHYL-2-PYRIDINOL;6-HYDROXY-3-PICOLINE;5-METHYL-PYRIDIN-2-OL;2-Hydroxy-5-Piocoline
- CBNumber
- CB5114924
- Molecular Formula
- C6H7NO
- Formula Weight
- 109.13
- MOL File
- 1003-68-5.mol
2-Hydroxy-5-methylpyridine Property
- Melting point:
- 183-187 °C (lit.)
- Boiling point:
- 304.2±15.0 °C(Predicted)
- Density
- 1.053±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 12.43±0.10(Predicted)
- color
- Pale Yellow to Light Yellow
- BRN
- 107074
- InChI
- InChI=1S/C6H7NO/c1-5-2-3-6(8)7-4-5/h2-4H,1H3,(H,7,8)
- InChIKey
- SOHMZGMHXUQHGE-UHFFFAOYSA-N
- SMILES
- C1(=O)NC=C(C)C=C1
- CAS DataBase Reference
- 1003-68-5(CAS DataBase Reference)
- NIST Chemistry Reference
- 2(1H)-pyridinone, 5-methyl-(1003-68-5)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-37/38-41-36/37/39
- Safety Statements
- 26-36-37
- WGK Germany
- 3
- HS Code
- 29333990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
N-Bromosuccinimide Price
- Product number
- T162647
- Product name
- 5-METHYL-2(1H)-PYRIDINONE
- Purity
- AldrichCPR
- Packaging
- 1MG
- Price
- $139
- Updated
- 2024/03/01
- Product number
- 593427
- Product name
- 2-Hydroxy-5-methylpyridine
- Purity
- 97%
- Packaging
- 1g
- Price
- $53.8
- Updated
- 2024/03/01
- Product number
- H1167
- Product name
- 2-Hydroxy-5-methylpyridine
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $22
- Updated
- 2024/03/01
- Product number
- H1167
- Product name
- 2-Hydroxy-5-methylpyridine
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $69
- Updated
- 2024/03/01
- Product number
- L19528
- Product name
- 2-Hydroxy-5-methylpyridine, 98%
- Packaging
- 5g
- Price
- $58.65
- Updated
- 2024/03/01
2-Hydroxy-5-methylpyridine Chemical Properties,Usage,Production
Chemical Properties
White Solid
Uses
2-Hydroxy-5-methylpyridine (cas# 1003-68-5) is a useful compound for organic synthesis. In particular it has been used for the diastereoselective preparation of cyclobutane-fused pyridinyl sulfonyl fluorides. 2-hydroxy-5-methylpyridine and Iodobenzene were the impurities present in Pirfenidone (PFD) drug substance. PFD is a novel antifibrotic agent approved for mild to moderate Idiopathic pulmonary fibrosis (IPF) as orphan drug[1].
Definition
ChEBI: 5-Methyl-2-pyridinol is a member of methylpyridines.
Synthesis
3-cyano-6-hydroxypyridine and sodium lauryl sulfate were added to a mixed solvent of n-butanol and water. Subsequently, the temperature was raised to 50 °C., and sulfuric acid water obtained by dissolving 98% sulfuric acid in water was added dropwise at the temperature. After stirring for about 20 minutes, the mixture was cooled to room temperature, and 5% Pd / C was added. The system was replaced with hydrogen, and hydrogenation was carried out at atmospheric pressure for 6 hours. After the reaction was completed, the catalyst was removed by filtration, and the solution was washed with 10% sodium hydroxide aqueous solution. After partially neutralizing to H = 5 and extraction with n-butanol, a solution of crude 3-methyl-6-hydroxypyridine in butanol was obtained. When this solution was quantified by liquid chromatography, the pass-through rate was 99.2%, and the yield of 2-hydroxy-5-methylpyridine was 83%.
References
[1] Suresh Babu Bodempudi, ;K. S. Reddy, Ravichandra Babur. “Development and Substantiation of a RP-HPLC Method for Monitoring of Impurities in Pirfenidone Drug Substance.” 美国分析化学(英文) 6 1 (2015): 1019–1029.
2-Hydroxy-5-methylpyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Hydroxy-5-methylpyridine manufacturers
- Product
- 2-Hydroxy-5-methylpyridine 1003-68-5
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10kg/month
- Release date
- 2022-12-28
- Product
- 5-methylpyridin-2-ol 1003-68-5
- Price
- US $0.00-0.00/kg
- Min. Order
- 0.1kg
- Purity
- 0.99
- Supply Ability
- 1 tons
- Release date
- 2024-11-15
- Product
- 2-Hydroxy-5-methylpyridine 1003-68-5
- Price
- US $0.00/gm
- Min. Order
- 100gm
- Purity
- 99%min
- Supply Ability
- 100kgs
- Release date
- 2024-09-04