Telatinib
- Product Name
- Telatinib
- CAS No.
- 332012-40-5
- Chemical Name
- Telatinib
- Synonyms
- CS-361;CS-1854;Telatnib;Bay 57-9352;Unii-18p7197Q7j;Telatinib USP/EP/BP;Telatinib(BAY 57-9352);4-((4-(4-chlorophenylamino)furo[2,3-d]pyridazin-7-yloxy)methyl)-N-methylpicolinamide;4-[[4-(4-Chloroanilino)furo[2,3-d]pyridazin-7-yl]oxymethyl]-N-methyl-pyridine-2-carboxamide;4-[[[4-[(4-Chlorophenyl)amino]furo[2,3-d]pyridazin-7-yl]oxy]methyl]-N-methyl-2-pyridinecarboxamide
- CBNumber
- CB51179861
- Molecular Formula
- C20H16ClN5O3
- Formula Weight
- 409.83
- MOL File
- 332012-40-5.mol
Telatinib Property
- Boiling point:
- 713.6±60.0 °C(Predicted)
- Density
- 1.417
- storage temp.
- Store at -20°C
- solubility
- insoluble in H2O; insoluble in EtOH; ≥20.5 mg/mL in DMSO
- form
- solid
- pka
- 14.18±0.46(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 26203
- Product name
- Telatinib
- Packaging
- 5mg
- Price
- $98
- Updated
- 2024/03/01
- Product number
- 26203
- Product name
- Telatinib
- Packaging
- 50mg
- Price
- $728
- Updated
- 2024/03/01
- Product number
- 26203
- Product name
- Telatinib
- Packaging
- 10mg
- Price
- $167
- Updated
- 2024/03/01
- Product number
- 26203
- Product name
- Telatinib
- Packaging
- 25mg
- Price
- $389
- Updated
- 2024/03/01
- Product number
- T015700
- Product name
- Telatinib
- Packaging
- 10mg
- Price
- $145
- Updated
- 2021/12/16
Telatinib Chemical Properties,Usage,Production
Description
Telatinib is a multi-kinase inhibitor that inhibits VEGF receptor 2 (VEGFR2), VEGFR3, PDGFRα, and c-Kit (IC50s = 6, 4, 15, and 1 nM, respectively). It also binds to the transmembrane region of the ABCG2 efflux transporter and enhances intracellular accumulation of [3H]-mitoxantrone in ABCG2-overexpressing cells. Telatinib (15 mg/kg) decreases tumor growth rate and size in an H460/MX20 mouse xenograft model.
Uses
Telatinib small-molecule inhibitor of vascular endothelial growth factor receptors 2 and 3 (VEGFR-2/-3) and platelet-derived growth factor receptor β tyrosine kinases. Telatinib is used therapeutically in patients with advanced solid tumors.
Uses
Telatinib (BAY 57-9352) is an orally available, potent multitargeted VEGFR-2, VEGFR-3, PDGFR-β and c-Kit tyrosine kinases inhibitor with an IC50 of 19 nM for the inhibition of VEGFR-2 autophosphorylation.
target
c-Kit
References
[1]. steeghs, n., et al., hypertension and rarefaction during treatment with telatinib, a small molecule angiogenesis inhibitor. clin cancer res, 2008. 14(11): p. 3470-6.
[2]. strumberg, d., et al., phase i dose escalation study of telatinib (bay 57-9352) in patients with advanced solid tumours. br j cancer, 2008. 99(10): p. 1579-85.
[3]. sodani, k., et al., telatinib reverses chemotherapeutic multidrug resistance mediated by abcg2 efflux transporter in vitro and in vivo. biochem pharmacol, 2014. 89(1): p. 52-61.
[4]. eskens, f.a., et al., phase i dose escalation study of telatinib, a tyrosine kinase inhibitor of vascular endothelial growth factor receptor 2 and 3, platelet-derived growth factor receptor beta, and c-kit, in patients with advanced or metastatic solid tumors. j clin oncol, 2009. 27(25): p. 4169-76.
Telatinib Preparation Products And Raw materials
Raw materials
Preparation Products
Telatinib Suppliers
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- 010-88886666-01 13112345678
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- CDXH21@126.com
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- China
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- Fax
- 86-21-57758967
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- China
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- 86-10-82849933
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- China
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- 021-021-58432009 400-005-6266
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- 021-58436166
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- China
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- 44751
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- Tel
- 13817811078
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- 86-021-50426522,50426273
- sales@jingyan-chemical.com
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- China
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- 60
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- 28-83379370 13880556291
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- 028-87747383
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- 021-50135380
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- +86 (531) 88811783
- Fax
- +86 (531) 55696010 QQ 1762738062
- sales@trio-pharmatech.com (International market)
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- China
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- Tel
- 0411-62910999 13889544652
- sales@meilune.com
- Country
- China
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View Lastest Price from Telatinib manufacturers
- Product
- Telatinib 332012-40-5
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-07-06