Lasofoxifene
- Product Name
- Lasofoxifene
- CAS No.
- 180916-16-9
- Chemical Name
- Lasofoxifene
- Synonyms
- (5R,6S)-;CP-336,156;Lasofoxifene;Lasofoxifene Base;(5R,6S)-6-phenyl-5-[4-(2-pyrrolidin-1-ylethoxy)phenyl]tetralin-2-ol;(5R,6S)-5,6,7,8-Tetrahydro-6-phenyl-5-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-2-naphthalenol;(5R-cis)-5,6,7,8-Tetrahydro-6-phenyl-5-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-2-naphthalenol;(5R,6S)-6-Phenyl-5-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-5,6,7,8-tetrahydronaphthalen-2-ol;2-Naphthalenol, 5,6,7,8-tetrahydro-6-phenyl-5-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-, (5R,6S)-
- CBNumber
- CB51246956
- Molecular Formula
- C28H31NO2
- Formula Weight
- 413.55
- MOL File
- 180916-16-9.mol
Lasofoxifene Property
- Melting point:
- 110-113°C
- Boiling point:
- 572.4±50.0 °C(Predicted)
- Density
- 1.150±0.06 g/cm3(Predicted)
- storage temp.
- Refrigerator
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 10.31±0.60(Predicted)
- color
- White to Off-White
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H318Causes serious eye damage
H360May damage fertility or the unborn child
H372Causes damage to organs through prolonged or repeated exposure
H400Very toxic to aquatic life
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313IF exposed or concerned: Get medical advice/attention.
P310Immediately call a POISON CENTER or doctor/physician.
P314Get medical advice/attention if you feel unwell.
P330Rinse mouth.
P391Collect spillage. Hazardous to the aquatic environment
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 21754
- Product name
- Lasofoxifene
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $121
- Updated
- 2024/03/01
- Product number
- 21754
- Product name
- Lasofoxifene
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $362
- Updated
- 2024/03/01
- Product number
- 21754
- Product name
- Lasofoxifene
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $662
- Updated
- 2024/03/01
- Product number
- 21754
- Product name
- Lasofoxifene
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $1201
- Updated
- 2024/03/01
- Product number
- L176500
- Product name
- Lasofoxifene
- Packaging
- 25mg
- Price
- $660
- Updated
- 2021/12/16
Lasofoxifene Chemical Properties,Usage,Production
Chemical Properties
Off-White Solid
Uses
A next-generation selective estrogen receptor modulator for treating disorders associated with increased bone turnover and osteopenia.
Definition
ChEBI: Lasofoxifene is a member of the class of tetralins that is 5,6,7,8-tetrahydronaphthalen-2-ol in which the hydrogens at positions 5 and 6 are replaced by 4-[2-(pyrrolidin-1-yl)ethoxy]phenyl and phenyl groups, respectively (the 5R,6S-stereoisomer). It is a selective estrogen receptor modulator indicated for the prevention and treatment of osteoporosis in post-menopausal women. It has a role as an antineoplastic agent, a cardioprotective agent, an estrogen receptor agonist, an estrogen receptor antagonist and a bone density conservation agent. It is a member of tetralins, an aromatic ether, a member of naphthols and a N-alkylpyrrolidine.
Clinical Use
Lasofoxifene is a very potent second-generation SERM currently in phase III clinical trials for the treatment and prevention of osteoporosis in postmenopausal women.
Lasofoxifene Preparation Products And Raw materials
Raw materials
Preparation Products
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