(3S,4S)-N-Boc-3-amino-4-hydroxypyrrolidine

Product Name: (3S,4S)-N-Boc-3-amino-4-hydroxypyrrolidine
CAS No.: 190792-74-6
Chemical Name: (3S,4S)-N-Boc-3-amino-4-hydroxypyrrolidine
Synonyms: (3S,4S)-N-Boc-4-hydroxypyrrolidine;(3S,4S)-1-BOC-3-AMINO-4-HYDROXYPYRROLIDINE;1-Boc-(3S,4S)-3-aMino-4-hydroxypyrrolidine;(3s,4s)-n-boc-3-amino-4-hydroxypyrrolidine;Trans-(3S,4S)-1-Boc-3-aMino-4-hydroxypyrrolidine;1-Boc-(3S,4S)-3-amino-4-hydroxypyrrolidine 98%;(3S,4S)-N-Boc-3-amino-4-hydroxypyrrolidine USP/EP/BP;(3S,4S)-tert-Butyl 3-amino-4-hydroxypyrrolidine-1-carboxylate;tert-butyl (3S,4S)-3-amino-4-hydroxypyrrolidine-1-carboxylate;(3S,4S)-4-aMino-1-N-tert-butyloxycarbonyl-3-hydroxypyrrolidine
CBNumber: CB51267601
Molecular Formula: C9H18N2O3
Formula Weight: 202.25
MOL File: 190792-74-6.mol

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(3S,4S)-N-Boc-3-amino-4-hydroxypyrrolidine Property

Boiling point:: 308.8±42.0 °C(Predicted)
Density: 1.179
storage temp.: 2-8°C(protect from light)
pka: 14.36±0.40(Predicted)
Appearance: White to off-white Solid
optical activity: 2.4° (C=0.01 g/ml, ETOH)
InChI: InChI=1S/C9H18N2O3/c1-9(2,3)14-8(13)11-4-6(10)7(12)5-11/h6-7,12H,4-5,10H2,1-3H3/t6-,7-/m0/s1
InChIKey: MOZOQDNRVPHFOO-BQBZGAKWSA-N
SMILES: N1(C(OC(C)(C)C)=O)C[C@H](O)[C@@H](N)C1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific

Product number: Z4343
Product name: 1-Boc-(3S,4S)-3-amino-4-hydroxypyrrolidine
Packaging: 250mg
Price: $139
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H56-1-1R
Product name: (3S,4S)-N-Boc-4-hydroxypyrrolidine
Packaging: 1g
Price: $675
Updated: 2021/12/16

Apolloscientific

Product number: OR308146
Product name: tert-Butyl(3R,4R)-3-amino-4-hydroxypyrrolidine-1-carboxylate
Purity: 97%
Packaging: 5g
Price: $986
Updated: 2021/12/16

Acrotein

Product number: UT02230
Product name: (3S,4S)-tert-Butyl3-amino-4-hydroxypyrrolidine-1-carboxylate
Purity: 97%
Packaging: 0.5g
Price: $88.85
Updated: 2021/12/16

Chemenu

Product number: CM116589
Product name: (3S,4S)-1-Boc-3-amino-4-hydroxypyrrolidine
Purity: 95%
Packaging: 5g
Price: $393
Updated: 2021/12/16

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(3S,4S)-N-Boc-3-amino-4-hydroxypyrrolidine Chemical Properties,Usage,Production

Uses

(3S,4S)-N-Boc-3-amino-4-hydroxypyrrolidine is used as a pharmaceutical intermediate.

Synthesis

1202067-33-1

190792-74-6

General procedure for the synthesis of 1-Boc-(3S,4S)-3-amino-4-hydroxypyrrolidine from the compound (CAS:1202067-33-1): trifluoroacetic acid (TFA, 3 drops) was added to a methanol (50 mL) solution of Intermediate 11 (5.1 g, 17.1 mmol) and the mixture was stirred for 2 hours. Subsequently, platinum oxide (100 mg, 0.44 mmol) was added to the mixture and stirred under hydrogen atmosphere for 18 hours. After completion of the reaction, the mixture was filtered through diatomaceous earth and the solvent was removed by vacuum evaporation. The crude product was recrystallized by dichloromethane (DCM) to afford 1-Boc-(3S,4S)-3-amino-4-hydroxypyrrolidine as a white solid (2.42 g, 71% yield). NMR hydrogen spectral (CDCl3) data: δ 3.99 (1H, m), 3.70 (2H, m), 3.34 (2H, m), 3.12 (1H, m), 1.48 (9H, s).

References

[1] Patent: WO2009/153554, 2009, A1. Location in patent: Page/Page column 40

(3S,4S)-N-Boc-3-amino-4-hydroxypyrrolidine Preparation Products And Raw materials

Raw materials

Preparation Products

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(3S,4S)-N-Boc-3-amino-4-hydroxypyrrolidine Suppliers

China 102 Europe 1 India 1 United Kingdom 1 United States 8 Global 113

Shanghai Finechem Biotechnology Co., Ltd.

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shanghai cooperpharm co.,LTD .

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View Lastest Price from (3S,4S)-N-Boc-3-amino-4-hydroxypyrrolidine manufacturers

Career Henan Chemical Co

Product: (3S,4S)-N-Boc-3-amino-4-hydroxypyrrolidine 190792-74-6
Price: US $1.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: Customized
Release date: 2018-12-18

190792-74-6, (3S,4S)-N-Boc-3-amino-4-hydroxypyrrolidineRelated Search:

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(3s,4s)-n-boc-3-amino-4-hydroxypyrrolidine

1-Pyrrolidinecarboxylicacid,3-amino-4-hydroxy-,1,1-dimethylethylester,(3S,4S)-(9CI)

(3S,4S)-3-Amino-4-hydroxypyrrolidine-1-carboxylic acid tert-butyl ester

(3S,4S)-tert-Butyl 3-amino-4-hydroxypyrrolidine-1-carboxylate

1-Boc-(3S,4S)-3-aMino-4-hydroxypyrrolidine

(3S,4S)-4-aMino-1-N-tert-butyloxycarbonyl-3-hydroxypyrrolidine

tert-butyl (3S,4S)-3-amino-4-hydroxypyrrolidine-1-carboxylate

(3S,4S)-N-Boc-4-hydroxypyrrolidine

Trans-(3S,4S)-1-Boc-3-aMino-4-hydroxypyrrolidine

tert-Butyl (3R,4R)-3-amino-4-hydroxypyrrolidine-1-carboxylate 97%

(3S,4S)-1-BOC-3-AMINO-4-HYDROXYPYRROLIDINE

1-Pyrrolidinecarboxylic acid, 3-amino-4-hydroxy-, 1,1-dimethylethyl ester, (3S,4S)-

(3S,4S)-N-Boc-3-amino-4-hydroxypyrrolidine USP/EP/BP

（3S,4S）-trans-Butyl3-Amino -4-hydroxypyrrolidine-1-carboxylate

1,1-Dimethylethyl (3S,4S)-3-amino-4-hydroxy-1-pyrrolidinecarboxylate

1-Boc-(3S,4S)-3-amino-4-hydroxypyrrolidine 98%

190792-74-6

AMINOACID