4-Fluoro-1H-indole-7-carbonitrile
- Product Name
- 4-Fluoro-1H-indole-7-carbonitrile
- CAS No.
- 313337-33-6
- Chemical Name
- 4-Fluoro-1H-indole-7-carbonitrile
- Synonyms
- SW-9;SWF-9;7-Cyano-4-fluoroindole;7-Cyano-4-fluoro-1H-indole;4-Fluoroindole-7-carbonitrile;4-fluoro-1H-indole-7-carbonitrile;1H-Indole-7-carbonitrile, 4-fluoro-;4-FLUORO-1H-INDOLE-7-CARBONITRILE 97%;1H-Indole-7-carbonitrile,4-fluoro-(9CI)
- CBNumber
- CB51278252
- Molecular Formula
- C9H5FN2
- Formula Weight
- 160.15
- MOL File
- 313337-33-6.mol
4-Fluoro-1H-indole-7-carbonitrile Property
- Boiling point:
- 357.0±22.0 °C(Predicted)
- Density
- 1.34±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 14.01±0.30(Predicted)
- Appearance
- White to off-white Solid
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- F600318
- Product name
- 4-Fluoro-1H-indole-7-carbonitrile
- Packaging
- 100mg
- Price
- $200
- Updated
- 2021/12/16
- Product number
- PC5980
- Product name
- 4-Fluoro-1H-indole-7-carbonitrile
- Purity
- 97%
- Packaging
- 250mg
- Price
- $97
- Updated
- 2021/12/16
- Product number
- 3H37-3-Y3
- Product name
- 4-Fluoro-1H-indole-7-carbonitrile
- Purity
- 97%
- Packaging
- 250mg
- Price
- $156
- Updated
- 2021/12/16
- Product number
- 125105
- Product name
- 4-Fluoro-1H-indole-7-carbonitrile
- Purity
- 95+%
- Packaging
- 1g
- Price
- $1073
- Updated
- 2021/12/16
- Product number
- 3360AB
- Product name
- 4-Fluoro-1H-indole-7-carbonitrile
- Packaging
- 5g
- Price
- $1702
- Updated
- 2021/12/16
4-Fluoro-1H-indole-7-carbonitrile Chemical Properties,Usage,Production
Uses
4-Fluoro-1H-indole-7-carbonitrile is used as a pharmaceutical intermediate.
Synthesis
292636-09-0
313337-33-6
Step A: A mixture of 4-fluoro-7-bromoindole (600 mg, 2.8 mmol) with cuprous cyanide (CuCN, 1.004 g, 11.2 mmol) in N,N-dimethylformamide (DMF, 4 mL) was heated and refluxed for 16 hours. Upon completion of the reaction, the mixture was cooled to room temperature and subsequently poured into a methanol solution saturated with ammonia (30 mL) and filtered to remove insoluble residues. The filtrate was subsequently added to a mixture of water (20 mL) and saturated aqueous ammonia solution (20 mL) and extracted with ethyl acetate/ether (1:1, v/v) until thin-layer chromatography (TLC) analysis showed no product residue in the aqueous phase. The organic phases were combined, washed sequentially with saturated saline (2 x 200 mL) and water (200 mL), and dried over anhydrous magnesium sulfate (MgSO4). The organic phase was concentrated under reduced pressure to afford 4-fluoro-7-cyanoindole as a yellow-brown solid (310 mg, 69% yield).
References
[1] Patent: US6469006, 2002, B1
4-Fluoro-1H-indole-7-carbonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Fluoro-1H-indole-7-carbonitrile manufacturers
- Product
- 1H-Indole-7-carbonitrile,4-fluoro-(9CI) 313337-33-6
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- 95%min
- Supply Ability
- 20kg/month
- Release date
- 2019-12-20