4-Fluoro-1H-indole-7-carbonitrile

Product Name: 4-Fluoro-1H-indole-7-carbonitrile
CAS No.: 313337-33-6
Chemical Name: 4-Fluoro-1H-indole-7-carbonitrile
Synonyms: SW-9;SWF-9;7-Cyano-4-fluoroindole;7-Cyano-4-fluoro-1H-indole;4-Fluoroindole-7-carbonitrile;4-fluoro-1H-indole-7-carbonitrile;1H-Indole-7-carbonitrile, 4-fluoro-;4-FLUORO-1H-INDOLE-7-CARBONITRILE 97%;1H-Indole-7-carbonitrile,4-fluoro-(9CI)
CBNumber: CB51278252
Molecular Formula: C9H5FN2
Formula Weight: 160.15
MOL File: 313337-33-6.mol

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4-Fluoro-1H-indole-7-carbonitrile Property

Boiling point:: 357.0±22.0 °C(Predicted)
Density: 1.34±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 14.01±0.30(Predicted)
Appearance: White to off-white Solid

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: F600318
Product name: 4-Fluoro-1H-indole-7-carbonitrile
Packaging: 100mg
Price: $200
Updated: 2021/12/16

Apolloscientific

Product number: PC5980
Product name: 4-Fluoro-1H-indole-7-carbonitrile
Purity: 97%
Packaging: 250mg
Price: $97
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H37-3-Y3
Product name: 4-Fluoro-1H-indole-7-carbonitrile
Purity: 97%
Packaging: 250mg
Price: $156
Updated: 2021/12/16

Matrix Scientific

Product number: 125105
Product name: 4-Fluoro-1H-indole-7-carbonitrile
Purity: 95+%
Packaging: 1g
Price: $1073
Updated: 2021/12/16

AK Scientific

Product number: 3360AB
Product name: 4-Fluoro-1H-indole-7-carbonitrile
Packaging: 5g
Price: $1702
Updated: 2021/12/16

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4-Fluoro-1H-indole-7-carbonitrile Chemical Properties,Usage,Production

Uses

4-Fluoro-1H-indole-7-carbonitrile is used as a pharmaceutical intermediate.

Synthesis

292636-09-0

313337-33-6

Step A: A mixture of 4-fluoro-7-bromoindole (600 mg, 2.8 mmol) with cuprous cyanide (CuCN, 1.004 g, 11.2 mmol) in N,N-dimethylformamide (DMF, 4 mL) was heated and refluxed for 16 hours. Upon completion of the reaction, the mixture was cooled to room temperature and subsequently poured into a methanol solution saturated with ammonia (30 mL) and filtered to remove insoluble residues. The filtrate was subsequently added to a mixture of water (20 mL) and saturated aqueous ammonia solution (20 mL) and extracted with ethyl acetate/ether (1:1, v/v) until thin-layer chromatography (TLC) analysis showed no product residue in the aqueous phase. The organic phases were combined, washed sequentially with saturated saline (2 x 200 mL) and water (200 mL), and dried over anhydrous magnesium sulfate (MgSO4). The organic phase was concentrated under reduced pressure to afford 4-fluoro-7-cyanoindole as a yellow-brown solid (310 mg, 69% yield).

References

[1] Patent: US6469006, 2002, B1

4-Fluoro-1H-indole-7-carbonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Fluoro-1H-indole-7-carbonitrile Suppliers

China 60 Europe 1 India 2 United Kingdom 1 United States 6 Global 70

CHEMSWORTH

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A.J Chemicals

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View Lastest Price from 4-Fluoro-1H-indole-7-carbonitrile manufacturers

Nanjing jinheyou Trading Co., Ltd.

Product: 1H-Indole-7-carbonitrile,4-fluoro-(9CI) 313337-33-6
Price: US $0.00/g
Min. Order: 1g
Purity: 95%min
Supply Ability: 20kg/month
Release date: 2019-12-20

313337-33-6, 4-Fluoro-1H-indole-7-carbonitrileRelated Search:

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1H-Indole-7-carbonitrile,4-fluoro-(9CI)

4-fluoro-1H-indole-7-carbonitrile

7-Cyano-4-fluoro-1H-indole

1H-Indole-7-carbonitrile, 4-fluoro-

7-Cyano-4-fluoroindole

4-FLUORO-1H-INDOLE-7-CARBONITRILE 97%

SWF-9

SW-9

4-Fluoroindole-7-carbonitrile

313337-33-6

HALIDE