2(1H)-Pyridinone,5-chloro-3-fluoro-(9CI)
- Product Name
- 2(1H)-Pyridinone,5-chloro-3-fluoro-(9CI)
- CAS No.
- 514797-96-7
- Chemical Name
- 2(1H)-Pyridinone,5-chloro-3-fluoro-(9CI)
- Synonyms
- 5-chloro-3-fluoro-1H-pyridin-2-one;5-chloro-3-fluoropyridin-2(1H)-one;5-chloro-3-fluoro-2(1H)-Pyridinone;5-chloro-3-fluoro-2-hdyroxypyridine;2(1H)-Pyridinone, 5-chloro-3-fluoro-;2(1H)-Pyridinone,5-chloro-3-fluoro-(9CI)
- CBNumber
- CB51285810
- Molecular Formula
- C5H3ClFNO
- Formula Weight
- 147.53
- MOL File
- 514797-96-7.mol
2(1H)-Pyridinone,5-chloro-3-fluoro-(9CI) Property
- Melting point:
- 71℃
- Boiling point:
- 219℃
- Density
- 1.46
- Flash point:
- 86℃
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- 8.90±0.10(Predicted)
- Appearance
- White to off-white Solid
- EPA Substance Registry System
- 2(1H)-Pyridinone, 5-chloro-3-fluoro- (514797-96-7)
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C584943
- Product name
- 5-Chloro-3-fluoro-2-hydroxypyridine
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- C584943
- Product name
- 5-Chloro-3-fluoro-2-hydroxypyridine
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- PC900618
- Product name
- 5-Chloro-3-fluoro-2-hydroxypyridine
- Purity
- 98%
- Packaging
- 1g
- Price
- $100
- Updated
- 2021/12/16
- Product number
- 126803
- Product name
- 5-Chloro-3-fluoropyridin-2-ol
- Purity
- >95%
- Packaging
- 1g
- Price
- $144
- Updated
- 2021/12/16
- Product number
- Z4818
- Product name
- 5-Chloro-3-fluoropyridin-2-ol
- Packaging
- 5g
- Price
- $161
- Updated
- 2021/12/16
2(1H)-Pyridinone,5-chloro-3-fluoro-(9CI) Chemical Properties,Usage,Production
Synthesis
89402-43-7
514797-96-7
Example 6 (a) Synthesis of 5-chloro-3-fluoro-2-hydroxypyridine: Sodium hydroxide (101 g, 2.5 mol) was dissolved in water (500 mL) and liquid 5-chloro-2,3-difluoropyridine (101 g, 0.68 mol) was slowly added to this solution. The reaction mixture was heated to reflux and held overnight. After completion of the reaction, it was cooled to room temperature and the mixture was filtered through a diatomaceous earth pad. Subsequently, the pH of the filtrate was adjusted with concentrated hydrochloric acid to 1. The precipitated solid was collected by filtration and dissolved in ethyl acetate. The combined organic phases were dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure. 2-Hydroxy-3-fluoro-5-chloropyridine was obtained as a white solid (78 g, 78% yield), and the product could be used in subsequent reactions without further purification. The structure of the product was confirmed by 1H NMR.
References
[1] Patent: US2008/242695, 2008, A1. Location in patent: Page/Page column 36
[2] Patent: EP2305672, 2011, A1. Location in patent: Page/Page column 88
2(1H)-Pyridinone,5-chloro-3-fluoro-(9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2(1H)-Pyridinone,5-chloro-3-fluoro-(9CI) manufacturers
- Product
- 5-chloro-3-fluoropyridin-2-ol 514797-96-7
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-27
- Product
- 2(1H)-Pyridinone,5-chloro-3-fluoro-(9CI) 514797-96-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2020-01-02