3-Thiophenecarbonitrile, 5-chloro-

Product Name: 3-Thiophenecarbonitrile, 5-chloro-
CAS No.: 1108712-56-6
Chemical Name: 3-Thiophenecarbonitrile, 5-chloro-
Synonyms: 5-chlorothiophene-3-carbonitrile;5-Chloro-3-thiophenecarbonitrile;3-Thiophenecarbonitrile, 5-chloro-
CBNumber: CB72559037
Molecular Formula: C5H2ClNS
Formula Weight: 143.59
MOL File: 1108712-56-6.mol

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3-Thiophenecarbonitrile, 5-chloro- Property

Boiling point:: 203.2±20.0 °C(Predicted)
Density: 1.42±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
Appearance: Light brown to brown Solid-liquid mixture

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: C383165
Product name: 5-Chloro-3-thiophenecarbonitrile
Packaging: 10mg
Price: $45
Updated: 2021/12/16

SynQuest Laboratories

Product number: 7H66-5-56
Product name: 5-Chloro-3-thiophenecarbonitrile
Packaging: 250mg
Price: $244
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0367351
Product name: 5-CHLOROTHIOPHENE-3-CARBONITRILE
Purity: 95.00%
Packaging: 5MG
Price: $500.17
Updated: 2021/12/16

SynQuest Laboratories

Product number: 7H66-5-56
Product name: 5-Chloro-3-thiophenecarbonitrile
Packaging: 1g
Price: $645
Updated: 2021/12/16

Matrix Scientific

Product number: 112384
Product name: 5-Chloro-3-thiophenecarbonitrile
Packaging: 1g
Price: $923
Updated: 2021/12/16

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3-Thiophenecarbonitrile, 5-chloro- Chemical Properties,Usage,Production

Synthesis

1641-09-4

1108712-56-6

General procedure for the synthesis of 5-chloro-3-thiophenecarbonitrile from 3-cyanothiophene: Preparation of Intermediate 1M Synthesis: In a 100 mL three-necked round-bottomed flask, 3-cyanothiophene (5.0 g, 1 eq.) was dissolved in acetic acid (50 mL, 10 v/v), followed by N-chlorosuccinimide (6.73 g, 1.1 eq.). The reaction mixture was stirred at reflux temperature for 2-3 hours. The reaction progress was monitored by thin layer chromatography (TLC) using ethyl acetate: hexane (1:9) as mobile phase. Upon completion of the reaction, the mixture was cooled to room temperature and poured into an ice-water slurry (250 mL) and neutralized with sodium bicarbonate solution. The product was extracted with ethyl acetate (100 mL x 3). The organic layer was washed sequentially with brine solution (100 mL x 2) and dried over anhydrous sodium sulfate. The organic layer was concentrated under reduced pressure to give 5.0 g of crude product. Purification by fast column chromatography using ethyl acetate and hexane as eluents gave 2.4 g of pure product in 36.5% yield. MS/LCMS: m/z 177.0. nuclear magnetic resonance spectroscopy (NMR) confirmed the structure.

References

[1] Patent: WO2011/109799, 2011, A1. Location in patent: Page/Page column 145

3-Thiophenecarbonitrile, 5-chloro- Preparation Products And Raw materials

Raw materials

Preparation Products

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3-Thiophenecarbonitrile, 5-chloro- Suppliers

China 40 India 1 United States 5 Global 46

Beijing Ouhe Technology Co., Ltd

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View Lastest Price from 3-Thiophenecarbonitrile, 5-chloro- manufacturers

Career Henan Chemical Co

Product: 5-Chloro-3-thiophenecarbonitrile 1108712-56-6
Price: US $1.00/g
Min. Order: 1g
Purity: 95--99%
Supply Ability: 1ton
Release date: 2020-01-09

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1108712-56-6