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3-Thiophenecarbonitrile, 5-chloro-

Product Name
3-Thiophenecarbonitrile, 5-chloro-
CAS No.
1108712-56-6
Chemical Name
3-Thiophenecarbonitrile, 5-chloro-
Synonyms
5-chlorothiophene-3-carbonitrile;5-Chloro-3-thiophenecarbonitrile;3-Thiophenecarbonitrile, 5-chloro-
CBNumber
CB72559037
Molecular Formula
C5H2ClNS
Formula Weight
143.59
MOL File
1108712-56-6.mol
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3-Thiophenecarbonitrile, 5-chloro- Property

Boiling point:
203.2±20.0 °C(Predicted)
Density 
1.42±0.1 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
Appearance
Light brown to brown Solid-liquid mixture
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
C383165
Product name
5-Chloro-3-thiophenecarbonitrile
Packaging
10mg
Price
$45
Updated
2021/12/16
SynQuest Laboratories
Product number
7H66-5-56
Product name
5-Chloro-3-thiophenecarbonitrile
Packaging
250mg
Price
$244
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0367351
Product name
5-CHLOROTHIOPHENE-3-CARBONITRILE
Purity
95.00%
Packaging
5MG
Price
$500.17
Updated
2021/12/16
SynQuest Laboratories
Product number
7H66-5-56
Product name
5-Chloro-3-thiophenecarbonitrile
Packaging
1g
Price
$645
Updated
2021/12/16
Matrix Scientific
Product number
112384
Product name
5-Chloro-3-thiophenecarbonitrile
Packaging
1g
Price
$923
Updated
2021/12/16
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3-Thiophenecarbonitrile, 5-chloro- Chemical Properties,Usage,Production

Synthesis

1641-09-4

1108712-56-6

General procedure for the synthesis of 5-chloro-3-thiophenecarbonitrile from 3-cyanothiophene: Preparation of Intermediate 1M Synthesis: In a 100 mL three-necked round-bottomed flask, 3-cyanothiophene (5.0 g, 1 eq.) was dissolved in acetic acid (50 mL, 10 v/v), followed by N-chlorosuccinimide (6.73 g, 1.1 eq.). The reaction mixture was stirred at reflux temperature for 2-3 hours. The reaction progress was monitored by thin layer chromatography (TLC) using ethyl acetate: hexane (1:9) as mobile phase. Upon completion of the reaction, the mixture was cooled to room temperature and poured into an ice-water slurry (250 mL) and neutralized with sodium bicarbonate solution. The product was extracted with ethyl acetate (100 mL x 3). The organic layer was washed sequentially with brine solution (100 mL x 2) and dried over anhydrous sodium sulfate. The organic layer was concentrated under reduced pressure to give 5.0 g of crude product. Purification by fast column chromatography using ethyl acetate and hexane as eluents gave 2.4 g of pure product in 36.5% yield. MS/LCMS: m/z 177.0. nuclear magnetic resonance spectroscopy (NMR) confirmed the structure.

References

[1] Patent: WO2011/109799, 2011, A1. Location in patent: Page/Page column 145

3-Thiophenecarbonitrile, 5-chloro- Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3-Thiophenecarbonitrile, 5-chloro- manufacturers

Career Henan Chemical Co
Product
5-Chloro-3-thiophenecarbonitrile 1108712-56-6
Price
US $1.00/g
Min. Order
1g
Purity
95--99%
Supply Ability
1ton
Release date
2020-01-09

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  • 5-Chloro-3-thiophenecarbonitrile
  • 5-chlorothiophene-3-carbonitrile
  • 3-Thiophenecarbonitrile, 5-chloro-
  • 1108712-56-6