anhydrotetrodotoxin

Product Name: anhydrotetrodotoxin
CAS No.: 13072-89-4
Chemical Name: anhydrotetrodotoxin
Synonyms: 9-anhydro-TTX;4,9-Anhydro-TTX;anhydrotetrodotoxin;4,9-Anhydrotetrodotoxin;4,9-Dideoxy-4β,9β-epoxytetrodotoxin;(8S)-4,9-Dideoxy-4β,9β-epoxytetrodotoxin;4,9Anhydrotetrodotoxin,4,9 Anhydrotetrodotoxin;(4S,5aS,6S,8R,9S,10S,11S,11aR,12R)-2-Amino-1,4,5a,6,8,9,10,11-octahydro-9-(hydroxymethyl)-6,10-epoxy-4,8,11a-metheno-11aH-oxocino[4,3-f][1,3,5]oxadiazepine-6,9,11-triol;6,10-Epoxy-4,8,11a-metheno-11aH-oxocino[4,3-f][1,3,5]oxadiazepine-6,9,11-triol, 2-amino-1,4,5a,6,8,9,10,11-octahydro-9-(hydroxymethyl)-, (4S,5aS,6S,8R,9S,10S,11S,11aR,12R)-
CBNumber: CB51328746
Molecular Formula: C11H15N3O7
Formula Weight: 301.25
MOL File: 13072-89-4.mol

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anhydrotetrodotoxin Property

storage temp.: -20°
solubility: Soluble in Ethanol (up to 10 mg/ml).
form: A solid or film
color: Colorless
Water Solubility: Soluble to 1 mg/ml in water
Stability:: Stable for 2 years from date of purchase as supplied. Protect from exposure to light or moisture. Solutions are not stable. Solutions must be prepared fresh and used within 1 working day.

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 19084
Product name: 4,9-Anhydrotetrodotoxin
Purity: ≥98%
Packaging: 100μg
Price: $242
Updated: 2024/03/01

Tocris

Product number: 6159
Product name: 4,9-Anhydrotetrodotoxin
Purity: ≥98%(HPLC)
Packaging: 100U
Price: $227
Updated: 2021/12/16

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anhydrotetrodotoxin Chemical Properties,Usage,Production

Description

4,9-Anhydrotetrodotoxin (4,9-anhydro-TTX) is a derivative of TTX that selectively blocks inward sodium current through Na_v1.6 voltage-activated sodium channels (IC₅₀ = 7.8 nM in Xenopus oocytes). It demonstrates IC₅₀ values of 1.3, 0.34, 0.99, 78.5, 1.3, and >30 μM for Na_v1.2, Na_v1.3, Na_v1.4, Na_v1.5, Na_v1.7, and Na_v1.8, respectively.

storage

Store at -20°C

References

1) Rosker?et al. (2007),?The TTX metabolite 4,9-anhydro-TTX is a highly specific blocker of the Na(v1.6) voltage-dependent sodium channel; Am.J.Physiol.Cell Physiol.,?293?C783. 2) Denomme?et al.?(2020),??The voltage-gated sodium channel inhibitor, 4,9-anhydrotetrodotoxin, blocks human Nav1.1 in addition to Nav1.6;?Neurosci. Lett.?724?134853

anhydrotetrodotoxin Preparation Products And Raw materials

Raw materials

Preparation Products

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anhydrotetrodotoxin Suppliers

China 14 United Kingdom 1 United States 4 USA 1 Global 20

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
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United States Biological

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Focus Biomolecules

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ProdList: 1284
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Cayman Chemical Company

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Email: cayman@caymanchem.com
Country: United States
ProdList: 6213
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13072-89-4, anhydrotetrodotoxinRelated Search:

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anhydrotetrodotoxin

(8S)-4,9-Dideoxy-4β,9β-epoxytetrodotoxin

4,9-Anhydrotetrodotoxin

4,9-Dideoxy-4β,9β-epoxytetrodotoxin

(4S,5aS,6S,8R,9S,10S,11S,11aR,12R)-2-Amino-1,4,5a,6,8,9,10,11-octahydro-9-(hydroxymethyl)-6,10-epoxy-4,8,11a-metheno-11aH-oxocino[4,3-f][1,3,5]oxadiazepine-6,9,11-triol

6,10-Epoxy-4,8,11a-metheno-11aH-oxocino[4,3-f][1,3,5]oxadiazepine-6,9,11-triol, 2-amino-1,4,5a,6,8,9,10,11-octahydro-9-(hydroxymethyl)-, (4S,5aS,6S,8R,9S,10S,11S,11aR,12R)-

9-anhydro-TTX

4,9Anhydrotetrodotoxin,4,9 Anhydrotetrodotoxin

4,9-Anhydro-TTX

13072-89-4