ChemicalBook > CAS DataBase List > irisolidone

irisolidone

Product Name
irisolidone
CAS No.
2345-17-7
Chemical Name
irisolidone
Synonyms
irisoidone;irisolidone;4'-Methoxytectorigenin;4'-O-Methyltectorigenin;5,7-Dihydroxy-6,4'-dimethoxyisoflavon;5,7-dihydroxy-6-methoxy-3-(4-methoxyphenyl)-4H-chromen-4-one;5,7-Dihydroxy-6-methoxy-3-(4-methoxyphenyl)-4H-1-benzopyran-4-one;4H-1-Benzopyran-4-one, 5,7-dihydroxy-6-methoxy-3-(4-methoxyphenyl)-;Chloride Channel,Cl? Channels,Inhibitor,hepatoprotective,inhibit,VRAC,Irisolidone
CBNumber
CB51330783
Molecular Formula
C17H14O6
Formula Weight
314.29
MOL File
2345-17-7.mol
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irisolidone Property

Melting point:
190-191 °C
Boiling point:
565.5±50.0 °C(Predicted)
Density 
1.402±0.06 g/cm3(Predicted)
storage temp. 
4°C, protect from light
solubility 
Chloroform (Slightly), DMSO (Slightly)
form 
Solid
pka
6.48±0.20(Predicted)
color 
Off-White to Pale Yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Arctom
Product number
SY232783
Product name
5,7-Dihydroxy-6-methoxy-3-(4-methoxyphenyl)-4H-chromen-4-one
Purity
≥95%
Packaging
10mg
Price
$619.09
Updated
2021/12/16
Arctom
Product number
AS671770
Product name
Irisolidone
Purity
98%
Packaging
100mg
Price
$787
Updated
2021/12/16
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irisolidone Chemical Properties,Usage,Production

Description

Irisolidone is a hydrolyzed product of kudzurin. Studies have shown that it can significantly dilate coronary arteries, cerebral arteries and peripheral blood vessels and microvessels, and can reduce vascular resistance, cholesterol and blood viscosity.

Chemical Properties

Light yellow crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from kudzu.

Uses

Irisolidone has anti-inflammatory, antioxidant, antibacterial, anti-tumor, estrogen-like effects, and protects liver damage caused by alcoholism.

Definition

ChEBI: Irisolidone is a member of 4'-methoxyisoflavones.

Biological Activity

Irisolidone is the main isoflavone in pueraria. Irisolidone has strong hepatoprotective activity. It has a highly effective blocking effect on the anion channel VRAC.

in vitro

Irisolidone shows the high efficacy for Volume-regulated anion channels (VRAC) blockade with an IC 50 of 9.8 μM in HEK293 cells.
It can inhibit endothelial cell proliferation.

irisolidone Preparation Products And Raw materials

Raw materials

Preparation Products

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2345-17-7, irisolidoneRelated Search:

hydroxygenkwanin kakkalide Naringenin 7-O-β-D-Glucuronide (Mixture of Diastereomers) MEDICAGOL Quercetin-7-O-β-D-glucopyranoside GARDENIN B Naringenin PONCIRIN 2-(3,4-Dihydroxyphenyl)-8-(2-O-beta-L-galactopyranosyl-beta-D-glucopyranosyl)-5,7-dihydroxy-4H-1-Benzopyran-4-one MOSLOFLAVONE 4',5-DIHYDROXY-7-METHOXYFLAVONE Isoflavone Puerarin Puerarin Isoflavones 5,7-dihydroxy-6-[(2S,3S,4R,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)ox an-2-yl]-2-[4-[(2S,3S,4R,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan -2-yl]oxyphenyl]chromen-4-one xanthatin (3aS)-3aβ,4,5,7,8,9,9aβ,9bα-Octahydro-9β-hydroxy-6,9-dimethyl-3-methyleneazuleno[4,5-b]furan-2(3H)-one 7-Xylosyl-10-deacetyltaxol

  • irisolidone
  • 5,7-Dihydroxy-6-methoxy-3-(4-methoxyphenyl)-4H-1-benzopyran-4-one
  • irisoidone
  • 4'-Methoxytectorigenin
  • 4'-O-Methyltectorigenin
  • 5,7-Dihydroxy-6,4'-dimethoxyisoflavon
  • 4H-1-Benzopyran-4-one, 5,7-dihydroxy-6-methoxy-3-(4-methoxyphenyl)-
  • 5,7-dihydroxy-6-methoxy-3-(4-methoxyphenyl)-4H-chromen-4-one
  • Chloride Channel,Cl? Channels,Inhibitor,hepatoprotective,inhibit,VRAC,Irisolidone
  • 2345-17-7