DMP 777
- Product Name
- DMP 777
- CAS No.
- 157341-41-8
- Chemical Name
- DMP 777
- Synonyms
- DMP 777;L 694458;L-694458; DMP-777; DMP777;(S)-N-((R)-1-(Benzo[d][1,3]dioxol-5-yl)butyl)-3,3-diethyl-2-(4-(4methyl-piperazine-1-carbonyl);(S)-N-((R)-1-(Benzo[d][1,3]dioxol-5-yl)butyl)-3,3-diethyl-2-(4-(4methyl-piperazine-1-carbonyl)phe;(S)-N-((R)-1-(Benzo[d][1,3]dioxol-5-yl)butyl)-3,3-diethyl-2-(4-(4-Methylpiperazine-1-carbonyl)phenoxy)-4-oxoazetidine-1-carboxaMide;(2S)-N-[(1R)-1-(1,3-Benzodioxol-5-yl)butyl]-3,3-diethyl-2-[4-[(4-methyl-1-piperazinyl)carbonyl]phenoxy]-4-oxo-1-azetidinecarboxamide;1-AzetidinecarboxaMide,N-[(1R)-1-(1,3-benzodioxol-5-yl)butyl]-3,3-diethyl-2-[4-[(4-Methyl-1-piperazinyl)carbonyl]phenoxy]-4-oxo-,(2S)-;(S)-N-((R)-1-(Benzo[d][1,3]dioxol-5-yl)butyl)-3,3-diethyl-2-(4-(4methyl-piperazine-1-carbonyl)phenoxy)-4-oxoazetidine-1-carboxamide (3.5% w/w solution)
- CBNumber
- CB51333719
- Molecular Formula
- C31H40N4O6
- Formula Weight
- 564.67
- MOL File
- 157341-41-8.mol
DMP 777 Property
- Density
- 1.227
- storage temp.
- Store at -20°C
- solubility
- DMSO : 38.33 mg/mL (67.88 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
- form
- Powder
- pka
- pKa 7.04(H2O tunde?ned Iunde?ned) (Uncertain)
N-Bromosuccinimide Price
- Product number
- CS-0355
- Product name
- DMP777
- Purity
- 99.13%
- Packaging
- 10mg
- Price
- $300
- Updated
- 2021/12/16
- Product number
- FB167347
- Product name
- (S)-N-((R)-1-(Benzo[d][1,3]dioxol-5-yl)butyl)-3,3-diethyl-2-(4-(4-methylpiperazine-1-carbonyl)phenoxy)-4-oxoazetidine-1-carboxamide
- Packaging
- 2mg
- Price
- $300
- Updated
- 2021/12/16
- Product number
- KIN0001205
- Product name
- L-694458
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $496.38
- Updated
- 2021/12/16
- Product number
- CS-0355
- Product name
- DMP777
- Purity
- 99.13%
- Packaging
- 25mg
- Price
- $510
- Updated
- 2021/12/16
- Product number
- CS-0355
- Product name
- DMP777
- Purity
- 99.13%
- Packaging
- 5mg
- Price
- $200
- Updated
- 2021/12/16
DMP 777 Chemical Properties,Usage,Production
Biological Activity
DMP 777 is a potent, selective, orally available inhibitor of human leukocyte elastase (HLE).
in vivo
DMP-777-treated rats show a marked decrease in H/K-ATPase staining parietal cells. DMP-777-induced loss of parietal cells is significantly ameliorated with coadministration of omeprazole. DMP-777-treated animals demonstrates marked foveolar hyperplasia in the fundus with prominent expansion of diastase-resistant, PAS-positive surface mucous cells. When DMP-777 is coadministered with omprazole, there is a significant decrease in BrdUpositive S-phase cells compared with rats that receive DMP-777 alone. After oral dosing of monkeys at 40 mg/kg with DMP-777 the only stereoisomer detected in the post-dose plasma samples is the starting material DMP-777, and no inversion of the configuration at positions 'a' and 'b' of DMP- 777 has occurred in vivo. Mist1-/- mice treated with DMP-777 show fewer chief cell to SPEM transitions. Mist1-/- mice treated with L635 demonstrates significantly fewer proliferative SPEM cells compared to control mice.
target
Human leukocyte elastase (HLE)
DMP 777 Preparation Products And Raw materials
Raw materials
Preparation Products
DMP 777 Suppliers
- Tel
- --
- Fax
- --
- sales@carbosynth.com
- Country
- United Kingdom
- ProdList
- 6005
- Advantage
- 58