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helichrysetin

Product Name: helichrysetin
CAS No.: 62014-87-3
Chemical Name: helichrysetin
Synonyms: Heliocentric;helichrysetin;Helichrysetin, 10 mM in DMSO;2',4,4'-Trihydroxy 6'-methoxychalcone;1-(2,4-Dihydroxy-6-methoxy-phenyl)-3-(4-hydroxy-phenyl)-propenone;(E)-1-(2,4-dihydroxy-6-methoxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one;(2E)-1-(2,4-Dihydroxy-6-methoxyphenyl)-3-(4-hydroxyphenyl)-2-propen-1-one;2-Propen-1-one, 1-(2,4-dihydroxy-6-methoxyphenyl)-3-(4-hydroxyphenyl)-, (2E)-;Inhibitor,Apoptosis,growth,DCIS,Helichrysetin,inhibit,cell,cycle,ID2,anticancer
CBNumber: CB51354545
Molecular Formula: C16H14O5
Formula Weight: 286.28
MOL File: 62014-87-3.mol

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helichrysetin Property

Melting point:: 220 °C (decomp)
Boiling point:: 532.0±50.0 °C(Predicted)
Density: 1.369±0.06 g/cm3(Predicted)
storage temp.: -20°C, protect from light
solubility: Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form: powder
pka: 7.08±0.40(Predicted)
color: Yellow
LogP: 3.080 (est)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Arctom

Product number: CFN97065
Product name: Helichrysetin
Purity: ≥98%
Packaging: 5mg
Price: $463
Updated: 2021/12/16

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helichrysetin Chemical Properties,Usage,Production

Uses

Helichrysetin is isolated from the flower Helichrysum odoratissimum. Helichrysetin is an ID2 (DNA binding inhibitor 2) inhibitor. Helichrysetin induces apoptosis. Helichrysetin has anti-tumor and antioxidant activity[1][2][3].

Definition

ChEBI: Helichrysetin is a member of chalcones.

in vivo

Helichrysetin (10 mg/kg, Intraperitoneal injection) can inhibit DCIS growth in mice with no obvious side effects^[1].
Helichrysetin (3, 10, 30 mg/kg, Intraperitoneal injection) can inhibit tumor growth in a mouse model of gastric cancer cell transplantation^[3].

Animal Model:	MGC803 cell-xenografted mouse model^[3]
Dosage:	3, 10, 30 mg/kg
Administration:	i.p.
Result:	Decreased the tumor size and weight without an obvious effect on body weight in nude mice. Reduced the expression of Ki67 and increased the number of apoptotic cells in tumor tissues.

target

HIV

References

[1] Liu Y, et al. ID2 and GJB2 promote early-stage breast cancer progression by regulating cancer stemness. Breast Cancer Res Treat. 2019 May;175(1):77-90. DOI:10.1007/s10549-018-05126-3
[2] Ho YF, et al. Induction of apoptosis and cell cycle blockade by helichrysetin in a549 human lung adenocarcinoma cells. Evid Based Complement Alternat Med. 2013;2013:857257. DOI:10.1155/2013/857257
[3] Wang P, et al. Helichrysetin inhibits gastric cancer growth by targeting c-Myc/PDHK1 axis-mediated energy metabolism reprogramming. Acta Pharmacol Sin. 2022 Jun;43(6):1581-1593. DOI:10.1038/s41401-021-00750-0

helichrysetin Preparation Products And Raw materials

Raw materials

Preparation Products

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62014-87-3, helichrysetinRelated Search:

ISOBAVACHALCONE Hydroxysafflor yellow A 1-[2-Hydroxy-4-methoxy-5-(3-methyl-2-butenyl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one NARINGENIN CHALCONE 4'-Hydroxy-2,4-dimethoxychalcone Methyllucidone Linderone Ethyllucidone Calyxin B 2',4'-Dihydroxy-2,3',6'-trimethoxychalcone methyllinderone ROBTEIN 2-[(1Z,2E)-1-Hydroxy-3-phenyl-2-propenylidene]-4-methoxy-4-cyclopentene-1,3-dione 2'-HYDROXY-3,4,5,6'-TETRAMETHOXYCHALCONE Pashanone 2'-O-Methylisoliquiritigenin 2',4'-Dihydroxy-3',6'-dimethoxychalcone 5,7,8-TRIHYDROXYFLAVONE

helichrysetin

1-(2,4-Dihydroxy-6-methoxy-phenyl)-3-(4-hydroxy-phenyl)-propenone

(E)-1-(2,4-dihydroxy-6-methoxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one

2-Propen-1-one, 1-(2,4-dihydroxy-6-methoxyphenyl)-3-(4-hydroxyphenyl)-, (2E)-

(2E)-1-(2,4-Dihydroxy-6-methoxyphenyl)-3-(4-hydroxyphenyl)-2-propen-1-one

Heliocentric

Inhibitor,Apoptosis,growth,DCIS,Helichrysetin,inhibit,cell,cycle,ID2,anticancer

2',4,4'-Trihydroxy 6'-methoxychalcone

Helichrysetin, 10 mM in DMSO

62014-87-3