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helichrysetin

Product Name
helichrysetin
CAS No.
62014-87-3
Chemical Name
helichrysetin
Synonyms
Heliocentric;helichrysetin;Helichrysetin, 10 mM in DMSO;2',4,4'-Trihydroxy 6'-methoxychalcone;1-(2,4-Dihydroxy-6-methoxy-phenyl)-3-(4-hydroxy-phenyl)-propenone;(E)-1-(2,4-dihydroxy-6-methoxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one;(2E)-1-(2,4-Dihydroxy-6-methoxyphenyl)-3-(4-hydroxyphenyl)-2-propen-1-one;2-Propen-1-one, 1-(2,4-dihydroxy-6-methoxyphenyl)-3-(4-hydroxyphenyl)-, (2E)-;Inhibitor,Apoptosis,growth,DCIS,Helichrysetin,inhibit,cell,cycle,ID2,anticancer
CBNumber
CB51354545
Molecular Formula
C16H14O5
Formula Weight
286.28
MOL File
62014-87-3.mol
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helichrysetin Property

Melting point:
220 °C (decomp)
Boiling point:
532.0±50.0 °C(Predicted)
Density 
1.369±0.06 g/cm3(Predicted)
storage temp. 
-20°C, protect from light
solubility 
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form 
powder
pka
7.08±0.40(Predicted)
color 
Yellow
LogP
3.080 (est)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Arctom
Product number
CFN97065
Product name
Helichrysetin
Purity
≥98%
Packaging
5mg
Price
$463
Updated
2021/12/16
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helichrysetin Chemical Properties,Usage,Production

Uses

Helichrysetin is isolated from the flower Helichrysum odoratissimum. Helichrysetin is an ID2 (DNA binding inhibitor 2) inhibitor. Helichrysetin induces apoptosis. Helichrysetin has anti-tumor and antioxidant activity[1][2][3].

Definition

ChEBI: Helichrysetin is a member of chalcones.

in vivo

Helichrysetin (10 mg/kg, Intraperitoneal injection) can inhibit DCIS growth in mice with no obvious side effects[1].
Helichrysetin (3, 10, 30 mg/kg, Intraperitoneal injection) can inhibit tumor growth in a mouse model of gastric cancer cell transplantation[3].

Animal Model:MGC803 cell-xenografted mouse model[3]
Dosage:3, 10, 30 mg/kg
Administration:i.p.
Result:Decreased the tumor size and weight without an obvious effect on body weight in nude mice. Reduced the expression of Ki67 and increased the number of apoptotic cells in tumor tissues.

target

HIV

References

[1] Liu Y, et al. ID2 and GJB2 promote early-stage breast cancer progression by regulating cancer stemness. Breast Cancer Res Treat. 2019 May;175(1):77-90. DOI:10.1007/s10549-018-05126-3
[2] Ho YF, et al. Induction of apoptosis and cell cycle blockade by helichrysetin in a549 human lung adenocarcinoma cells. Evid Based Complement Alternat Med. 2013;2013:857257. DOI:10.1155/2013/857257
[3] Wang P, et al. Helichrysetin inhibits gastric cancer growth by targeting c-Myc/PDHK1 axis-mediated energy metabolism reprogramming. Acta Pharmacol Sin. 2022 Jun;43(6):1581-1593. DOI:10.1038/s41401-021-00750-0

helichrysetin Preparation Products And Raw materials

Raw materials

Preparation Products

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helichrysetin Suppliers

China 84 United States 6 USA 1 Global 91

62014-87-3, helichrysetinRelated Search:

ISOBAVACHALCONE Hydroxysafflor yellow A 1-[2-Hydroxy-4-methoxy-5-(3-methyl-2-butenyl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one NARINGENIN CHALCONE 4'-Hydroxy-2,4-dimethoxychalcone Methyllucidone Linderone Ethyllucidone Calyxin B 2',4'-Dihydroxy-2,3',6'-trimethoxychalcone methyllinderone ROBTEIN 2-[(1Z,2E)-1-Hydroxy-3-phenyl-2-propenylidene]-4-methoxy-4-cyclopentene-1,3-dione 2'-HYDROXY-3,4,5,6'-TETRAMETHOXYCHALCONE Pashanone 2'-O-Methylisoliquiritigenin 2',4'-Dihydroxy-3',6'-dimethoxychalcone 5,7,8-TRIHYDROXYFLAVONE

  • helichrysetin
  • 1-(2,4-Dihydroxy-6-methoxy-phenyl)-3-(4-hydroxy-phenyl)-propenone
  • (E)-1-(2,4-dihydroxy-6-methoxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one
  • 2-Propen-1-one, 1-(2,4-dihydroxy-6-methoxyphenyl)-3-(4-hydroxyphenyl)-, (2E)-
  • (2E)-1-(2,4-Dihydroxy-6-methoxyphenyl)-3-(4-hydroxyphenyl)-2-propen-1-one
  • Heliocentric
  • Inhibitor,Apoptosis,growth,DCIS,Helichrysetin,inhibit,cell,cycle,ID2,anticancer
  • 2',4,4'-Trihydroxy 6'-methoxychalcone
  • Helichrysetin, 10 mM in DMSO
  • 62014-87-3