Mozavaptan

Product Name: Mozavaptan
CAS No.: 137975-06-5
Chemical Name: Mozavaptan
Synonyms: CS-134;OPC31260l;OPC 31260;MOZAVAPTAN;Mozavaptan USP/EP/BP;Mozavaptan (OPC-31260);N-(4-(5-(Dimethylamino);OPC-31260; OPC31260L; OPC 31260;-2,3,4,5-tetrahydro-1H-benzo[b]azepine-1-carbonyl);5-(Dimethylamino)-1-[4-(2-methylbenzamido)benzoyl]-2,3,4,5-tetrahydro-1H-benzazepine
CBNumber: CB51388577
Molecular Formula: C27H29N3O2
Formula Weight: 427.54
MOL File: 137975-06-5.mol

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Mozavaptan Property

Melting point:: 213 - 217°C
Boiling point:: 543.0±50.0 °C(Predicted)
Density: 1.21±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 13.04±0.70(Predicted)
color: White to Off-White

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: M732720
Product name: Mozavaptan
Packaging: 5mg
Price: $130
Updated: 2021/12/16

ApexBio Technology

Product number: B2299
Product name: Mozavaptan
Packaging: 10mg
Price: $95
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD71413
Product name: 5-(Dimethylamino)-1-[4-(2-methylbenzamido)benzoyl]-2,3,4,5-tetrahydro-1H-benzazepine
Packaging: 100mg
Price: $120
Updated: 2021/12/16

ChemScene

Product number: CS-6286
Product name: Mozavaptan
Purity: 99.89%
Packaging: 10mg
Price: $60
Updated: 2021/12/16

ChemScene

Product number: CS-6286
Product name: Mozavaptan
Purity: 99.89%
Packaging: 50mg
Price: $180
Updated: 2021/12/16

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Mozavaptan Chemical Properties,Usage,Production

Description

Mozavaptan is an oral vasopressin V2 antagonist that has been launched in Japan for inappropriate antidiuretic hormone secretion syndrome (IADHS), an affliction manifesting as hyponatremia. It joins another nonpeptidic benzazepine, conivaptan, which corrects sodium and water imbalance by blocking the renal V2 receptor resulting in enhanced diuresis, thereby effectively increasing serum sodium concentration. While conivaptan inhibits both V1 and V2 receptors, mozavaptan is significantly more selective for V2 (IC50 of 14nM vs. 1.2 mM for V1).

Originator

Otsuka (Japan)

Uses

Mozavaptan is a vasopressin-receptor antagonist. It is used in the treatment of congestive heart failure and hyponatremia.

Uses

vasopressin V2 receptor antagonist

Definition

ChEBI: Mozavaptan is a member of benzamides.

brand name

Physuline

Synthesis

The reported synthesis of mozavaptan is shown in the scheme. Readily available benzazepin-5-one 39 was refluxed with 40% methyl amine methanol solution in the presence of molecular sieves for 5h followed by the reduction of the resulting imine with sodium borohydride to give the monomethyl amine. Reductive alkylation of the monomethyl amine with formaldehyde in the presence of sodium cyanoborohydride gave the dimethyl amino benzazepine 40. Removal of the tosyl group was facilitated by heating 40 in polyphosphoric acid at 150oC for 2 h to give 41 in 97% yield. Reaction of the resulting benzazepine 41 with p-nitrobenzoyl chloride (42) in the presence of triethylamine provided amide 43 which was hydrogenated in the presence of 10% Pd/C in ethanol at room temperature to give aniline 44. Acylation of aniline 44 with 2-methylbenzoylchloride (45) in the presence of triethylamine gave mozavaptan (VI) in 54% yield.

Mozavaptan Preparation Products And Raw materials

Raw materials

Preparation Products

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Mozavaptan Suppliers

China 115 France 1 Germany 1 India 1 United Kingdom 1 United States 16 Global 135

MedChemexpress LLC

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InvivoChem

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BOC Sciences

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View Lastest Price from Mozavaptan manufacturers

Hebei Weibang Biotechnology Co., Ltd

Product: Mozavaptan 137975-06-5
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-06

Hebei Mojin Biotechnology Co., Ltd

Product: Mozavaptan 137975-06-5
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2023-09-05

Zhuozhou Wenxi import and Export Co., Ltd

Product: Mozavaptan 137975-06-5
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

137975-06-5, MozavaptanRelated Search:

Pyrazine (S)-(+)-Benzyl glycidyl ether Iodobenzene N-ACETYL-L-TYROSINE ETHYL ESTER β-Lonone 3-Hydroxypyridine Pyrrolidine Indoline Isoquinoline Tolvaptan Pidotimod Mozavaptan 2,3,4,5-Tetrahydro-1H-benzo[b]azepine 2,3,4,5-TETRAHYDRO-1H-BENZO[B]AZEPIN-5-YLAMINE N-{4-[(methylamino)methyl]phenyl}acetamide 4-amino-N-(2-ethylphenyl)benzamide 4-AMINO-N-ETHYL-N-PHENYLBENZAMIDE Mozavaptan Hydrochloride

OPC 31260

MOZAVAPTAN

5-(Dimethylamino)-1-[4-(2-methylbenzamido)benzoyl]-2,3,4,5-tetrahydro-1H-benzazepine

Benzamide, N-[4-[[5-(dimethylamino)-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]carbonyl]phenyl]-2-methyl-

-2,3,4,5-tetrahydro-1H-benzo[b]azepine-1-carbonyl)

N-(4-(5-(Dimethylamino)

CS-134

OPC-31260; OPC31260L; OPC 31260

OPC31260l

N-[4-[[5-(dimethylamino)-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]carbonyl]phenyl]-2-methyl-

Mozavaptan USP/EP/BP

N-[4-[5-(dimethylamino)-2,3,4,5-tetrahydro-1-benzazepine-1-carbonyl]phenyl]-2-methylbenzamide

N-(4-(5-(Dimethylamino)-2,3,4,5-tetrahydro-1H-benzo[b]azepine-1-carbonyl)phenyl)-2-methylbenzamide

Mozavaptan (OPC-31260)

137975-06-5

Inhibitors

Pharmaceutical intermediate