Mozavaptan Hydrochloride
- Product Name
- Mozavaptan Hydrochloride
- CAS No.
- 138470-70-9
- Chemical Name
- Mozavaptan Hydrochloride
- Synonyms
- Mozavaptan HCl;OPC 31260 hydrochloride;Mozavaptan Hydrochloride;MOROBKPIULFQDC-UHFFFAOYSA-N;OPC 31260 hydrochloride >=98% (HPLC);5-(Dimethylamino)-1-[4-(2-methylbenzamido)benzoyl]-2,3,4,5-tetrahydro-1H-benzazepine hydrochloride;N-[4-(5-Dimethylamino-2,3,4,5-tetrahydro-1-benzazepine-1-carbonyl)phenyl]-2-methylbenzamide hydrochloride;N-[4-[[5-(Dimethylamino)-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]carbonyl]phenyl]-2-methylbenzamide hydrochloride;Benzamide,N-[4-[[5-(dimethylamino)-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]carbonyl]phenyl]-2-methyl-,hydrochloride (1:1)
- CBNumber
- CB11508553
- Molecular Formula
- C27H29N3O2.ClH
- Formula Weight
- 464.006
- MOL File
- 138470-70-9.mol
Mozavaptan Hydrochloride Property
- storage temp.
- 2-8°C
- solubility
- DMSO: ≥15mg/mL
- form
- powder
- color
- white to tan
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- O1266
- Product name
- OPC 31260 hydrochloride
- Purity
- ≥98% (HPLC)
- Packaging
- 10mg
- Price
- $95.3
- Updated
- 2024/03/01
- Product number
- O1266
- Product name
- OPC 31260 hydrochloride
- Purity
- ≥98% (HPLC)
- Packaging
- 50mg
- Price
- $388
- Updated
- 2024/03/01
- Product number
- 16664
- Product name
- Mozavaptan (hydrochloride)
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $36
- Updated
- 2024/03/01
- Product number
- 16664
- Product name
- Mozavaptan (hydrochloride)
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $58
- Updated
- 2024/03/01
- Product number
- 16664
- Product name
- Mozavaptan (hydrochloride)
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $126
- Updated
- 2024/03/01
Mozavaptan Hydrochloride Chemical Properties,Usage,Production
Uses
Mozavaptan is a benzazepine derivative that antagonizes the binding of arginine vasopressin (AVP) to vasopressin receptors located in the liver (V1; IC50 = 1.2 μM) and kidney (V2; IC50 = 14 nM). At 10-100 μg/kg, mozavaptan can inhibit the antidiuretic action of AVP, promoting aquaresis when administered intravenously to rats. The therapeutic potential of mozavaptan in ectopic antidiuretic hormone syndrome, heart failure, and other complications related to hyponatremia has been studied.
Definition
ChEBI: Mozavaptane hydrochloride is a member of benzamides.
Biochem/physiol Actions
OPC 31260 is a vasopressin V2 selective antagonist. Arginine vasopressin (AVP) plays an important part in circulatory and water homeostasis. The V2 receptor subtype is important in water retention, cardiac remodeling in congestive heart failure (CHF), and renal hemodynamic alterations, and is considered a target for polysystic kidney disease. OPC-31260 has been shown to inhibit the development of polycystic kidney disease in several animal models.
Mozavaptan Hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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