Nefazodone

Product Name: Nefazodone
CAS No.: 83366-66-9
Chemical Name: Nefazodone
Synonyms: SERZONE;Dutonin;Nefadar;BMY-13754;NEFAZODONE;MJ-13754-1;MJ-13754-I;Nefazodone base;l)-5-ethyl-4-(2-phenoxyethyl)-;Nefazodone (base and/or unspecified salts)
CBNumber: CB5144862
Molecular Formula: C25H32ClN5O2
Formula Weight: 470.01
MOL File: 83366-66-9.mol

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Nefazodone Property

Melting point:: 180-182°C
Boiling point:: 599.6±60.0 °C(Predicted)
Density: 1.23±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: ~11 mg/mL at 60 °C
form: solid
pka: pKa 6.5 (Uncertain)
color: white
CAS DataBase Reference: 83366-66-9(CAS DataBase Reference)
NIST Chemistry Reference: Nefazodone(83366-66-9)

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Safety

Safety Statements: 22-24/25
WGK Germany: 3
Hazardous Substances Data: 83366-66-9(Hazardous Substances Data)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: API0003523
Product name: NEFAZODONE
Purity: 95.00%
Packaging: 1G
Price: $800
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 12475
Product name: NefazodoneHCl
Packaging: 10mg
Price: $845
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0003523
Product name: NEFAZODONE
Purity: 95.00%
Packaging: 10G
Price: $4400
Updated: 2021/12/16

Crysdot

Product number: CD33000073
Product name: Nefazodone
Purity: 95+%
Packaging: 1g
Price: $772
Updated: 2021/12/16

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Nefazodone Chemical Properties,Usage,Production

Chemical Properties

Crystalline Solid

Originator

Dutonin,Bristol-Myers Squibb,USA

Uses

A selective serotonin 5-HT2 receptor antagonist. An antidepressant

Definition

ChEBI: Nefazodone is a N-arylpiperazine, a N-alkylpiperazine, a member of triazoles, a member of monochlorobenzenes and an aromatic ether. It has a role as an antidepressant, a serotonergic antagonist, a serotonin uptake inhibitor, an alpha-adrenergic antagonist and an analgesic.

brand name

Serzone (Bristol-Myers Squibb).

Therapeutic Function

Antidepressant

Biological Functions

Although nefazodone (Serzone) is structurally related to trazodone, it is less sedating. It does not block α₁- adrenoreceptors, and its use is not associated with priapism. Nefazodone inhibits the neuronal reuptake of serotonin and blocks 5HT2A receptors. Its short half-life requires dosing twice a day. Nefazodone is not associated with weight gain or sexual dysfunction. It inhibits the cytochrome P450 3A4 isoenzyme that is responsible for 50% of known oxidative metabolism, and therefore, nefazodone can elevate levels of drugs dependent on this pathway for metabolism.

Nefazodone Preparation Products And Raw materials

Raw materials

Urethane 3-Amino-5-mercapto-1,2,4-triazole Bromoethane 1-Bromo-3-chloropropane

Preparation Products

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Nefazodone Suppliers

Canada 3 China 37 Germany 2 India 2 Italy 1 Switzerland 1 The Netherlands 1 United Kingdom 3 United States 15 USA 1 Global 66

LGM Pharma

Tel: 1-(800)-881-8210
Fax: 615-250-9817
Email: inquiries@lgmpharma.com
Country: United States
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TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32161
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TargetMol Chemicals Inc.

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Alfa Chemistry

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Olinax Inc.

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ProdList: 404
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ACIC Fine Chemicals Inc.

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ProdList: 492
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Medical Isotopes

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Country: United States
ProdList: 6181
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Waterstone Technology, LLC

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ProdList: 6786
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Altan Corporation

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HONEST JOY HOLDINGS LIMITED

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ProdList: 6675
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SynFine Research

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LKT Laboratories, Inc.

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ChemPacific Corporation

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AK Scientific, Inc.

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Aagami, Inc.

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Country: United States
ProdList: 557
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View Lastest Price from Nefazodone manufacturers

Career Henan Chemical Co

Product: Nefazodone 83366-66-9
Price: US $1.00/KG
Min. Order: 1G
Purity: 98%
Supply Ability: 100KG
Release date: 2018-08-20

83366-66-9, NefazodoneRelated Search:

Trazodone Triadimefon Propyl butyrate Furazolidone N,N-Diisopropylethylamine 2-Ethylhexyl ferulate N-Aminoethylpiperazine Trazodone hydrochloride Piperacillin Ethylparaben Ethyl acrylate Ethanol Ethyl acetate Linezolid Dihydromyrcenol Levodropropizine Ethylbenzene Propyl gallate

3h-1,2,4-triazol-3-one,2,4-dihydro-2-3-(4-(3-chlorophenyl)-1-piperazinyl)propy

l)-5-ethyl-4-(2-phenoxyethyl)-

BMY-13754

SERZONE

MJ-13754-1

NEFAZODONE

2-[3-[4-(3-CHLOROPHENYL)-1-PIPERAZINYL]PROPYL]-5-ETHYL-2,4-DIHYDRO-4-(2-PHENOXYETHYL)-3H-1,2,4-TRIAZOL-3-ONE HYDROCHLORIDE

Nefazodone base

2-[3-[4-(3-Chlorophenyl)-1-piperazinyl]propyl]-5-ethyl-2,4-dihydro-4-(2-phenoxyethyl)-3H-1,2,4-triazol-3-one, Hydrochloride

3H-1,2,4-Triazol-3-one, 2-3-4-(3-chlorophenyl)-1-piperazinylpropyl-5-ethyl-2,4-dihydro-4-(2-phenoxyethyl)-

Nefazodone (base and/or unspecified salts)

Dutonin

MJ-13754-I

2-[3-[4-(3-Chlorophenyl)piperazino]propyl]-4-(2-phenoxyethyl)-5-ethyl-2H-1,2,4-triazole-3(4H)-one

2-[3-[4-(3-Chlorophenyl)-1-piperazinyl]propyl]-5-ethyl-2,4-dihydro-4-(2-phenoxyethyl)-3H-1,2,4-triazol-3-one

2-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-ethyl-4-(2-phenoxyethyl)-1,2,4-triazol-3-one

Nefadar

83366-66-9

C25H32ClN5O2

API

Intermediates & Fine Chemicals

Pharmaceuticals