CETRORELIX
- Product Name
- CETRORELIX
- CAS No.
- 145672-81-7
- Chemical Name
- CETRORELIX
- Synonyms
- Cetrorelix impurity;Ns 75a;D 20761;Ovurelix;Cetrotid;Sb 075 acetate;Cetrorelix acetate;Cetrorelix acetate;SB-075 ACETATE;NS-75A;Cetrorelix( x acetate)
- CBNumber
- CB51478311
- Molecular Formula
- C70H92ClN17O14.C2H4O2
- Formula Weight
- 1491.11
- MOL File
- 145672-81-7.mol
CETRORELIX Property
- storage temp.
- -20°C
- solubility
- methanol: soluble10%
- form
- solid
- color
- White to off-white
- Water Solubility
- Soluble in water
- Sequence
- N-acetyl-{2-Naph-Ala}-{Cl-Phe}-{3Py-Ala}-Ser-Tyr-{Cit}-Leu-Arg-Pro-Ala-NH2
- InChIKey
- KFEFLCOCAHJBEA-YIQVFHPZNA-N
N-Bromosuccinimide Price
- Product number
- C5249
- Product name
- Cetrorelix acetate
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $371
- Updated
- 2026/03/19
- Product number
- C5249
- Product name
- Cetrorelix acetate
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $568
- Updated
- 2026/03/19
- Product number
- 23910
- Product name
- Cetrorelix (acetate)
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $40
- Updated
- 2024/03/01
- Product number
- 23910
- Product name
- Cetrorelix (acetate)
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $99
- Updated
- 2024/03/01
- Product number
- 23910
- Product name
- Cetrorelix (acetate)
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $158
- Updated
- 2024/03/01
CETRORELIX Chemical Properties,Usage,Production
Description
Cetrorelix is a synthetic peptide antagonist of the gonadotropin-releasing hormone receptor (GnRHR) with a Kd value of 0.2 nM for radioligand binding to murine LTK- cells expressing human GnRHR. It inhibits the activation of hGnRHR and a downstream luciferase reporter gene in murine LTK- cells by the GnRHR agonist [D-Trp6]GnRH (IC50 = 1.2 nM). In vivo, cetrorelix (60 μg per day) reduces tumor volume to 35% of control and decreases serum luteinizing hormone levels by 50% in a human epithelial ovarian cancer mouse xenograft model. Centrorelix (0.5 mg/kg) protects the primordial follicles (PMF) in mouse ovaries from damage induced by cyclophosphamide with 65% to 86% PMF survival compared to 46% PMF survival with a saline control. Formulations containing cetrorelix have been used to prevent ovulation during in vitro fertilization.
Uses
Cetrorelix, a luteinizing hormone releasing hormone receptor (LHRHR) antagonist, was used to study its safety, mechanism of action, metabolism, and efficacy as a therapeutic agent for the treatment of blood cancers such as multiple myeloma (MM). Cetrorelix is used to evaluate its effects on a wide range of physiological processes and malignancies that involve luteinizing hormone releasing hormone receptor signaling pathways involving processes such as steroidogenesis.
Uses
Cetrorelix Acetate is an gonadotropin-releasing hormone antagonist and is used to treat hormone-sensitive cancers of the prostate and breast.
Definition
ChEBI: The acetic acid salt of cetrorelix. A gonadotrophin-releasing hormone (GnRH) antagonist, it is used for treatment of infertility and of hormone-sensitive cancers of the prostate and breast.
Biochem/physiol Actions
Cetrorelix acetate is a luteinizing hormone releasing hormone receptor antagonist. It causes prepubertal reduction in bone modeling, bone density and bone strength comparable to post-menopausal bone loss.
storage
Store at -20°C
References
[1] THOMAS BECKERS Peter H Helmut Reilnder. Characterization of Gonadotropin-Releasing Hormone Analogs Based on a Sensitive Cellular Luciferase Reporter Gene Assay[J]. Analytical biochemistry, 1997, 251 1: Pages 17-23. DOI: 10.1006/abio.1997.2208
[2] T YANO. Inhibition of growth of OV-1063 human epithelial ovarian cancer xenografts in nude mice by treatment with luteinizing hormone-releasing hormone antagonist SB-75.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1994, 91 15: 7090-7094. DOI: 10.1073/pnas.91.15.7090
[3] DROR MEIROW. The GnRH antagonist cetrorelix reduces cyclophosphamide-induced ovarian follicular destruction in mice.[J]. Human reproduction, 2004, 19 6: 1294-1299. DOI: 10.1093/humrep/deh257
CETRORELIX Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from CETRORELIX manufacturers
- Product
- Cetrorelix Acetate 145672-81-7
- Price
- US $2.00-5.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-06-19
- Product
- CETRORELIX 145672-81-7
- Price
- US $15.00/g
- Min. Order
- 1Kg/Bag
- Purity
- 99%
- Supply Ability
- 20 Tons
- Release date
- 2020-10-27
- Product
- CETRORELIX 145672-81-7
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kG
- Release date
- 2019-07-04