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CETRORELIX

Product Name
CETRORELIX
CAS No.
145672-81-7
Chemical Name
CETRORELIX
Synonyms
Cetrorelix impurity;Ns 75a;D 20761;Ovurelix;Cetrotid;Sb 075 acetate;SB-075 ACETATE;NS-75A;Cetrorelix( x acetate);Cetrorelix acetate (SB-75);Cetrorelix Acetate, 10 mM in DMSO
CBNumber
CB51478311
Molecular Formula
C70H92ClN17O14.C2H4O2
Formula Weight
1491.11
MOL File
145672-81-7.mol
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CETRORELIX Property

storage temp. 
-20°C
solubility 
methanol: soluble10%
form 
solid
color 
White to off-white
Water Solubility 
Soluble in water
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Safety

Risk Statements 
60-63
Safety Statements 
22
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Precautionary statements

P201Obtain special instructions before use.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C5249
Product name
Cetrorelix acetate
Purity
≥98% (HPLC)
Packaging
5mg
Price
$129
Updated
2024/03/01
Sigma-Aldrich
Product number
C5249
Product name
Cetrorelix acetate
Purity
≥98% (HPLC)
Packaging
25mg
Price
$516
Updated
2024/03/01
Cayman Chemical
Product number
23910
Product name
Cetrorelix (acetate)
Purity
≥95%
Packaging
1mg
Price
$40
Updated
2024/03/01
Cayman Chemical
Product number
23910
Product name
Cetrorelix (acetate)
Purity
≥95%
Packaging
5mg
Price
$99
Updated
2024/03/01
Cayman Chemical
Product number
23910
Product name
Cetrorelix (acetate)
Purity
≥95%
Packaging
10mg
Price
$158
Updated
2024/03/01
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CETRORELIX Chemical Properties,Usage,Production

Description

Cetrorelix is a synthetic peptide antagonist of the gonadotropin-releasing hormone receptor (GnRHR) with a Kd value of 0.2 nM for radioligand binding to murine LTK- cells expressing human GnRHR. It inhibits the activation of hGnRHR and a downstream luciferase reporter gene in murine LTK- cells by the GnRHR agonist [D-Trp6]GnRH (IC50 = 1.2 nM). In vivo, cetrorelix (60 μg per day) reduces tumor volume to 35% of control and decreases serum luteinizing hormone levels by 50% in a human epithelial ovarian cancer mouse xenograft model. Centrorelix (0.5 mg/kg) protects the primordial follicles (PMF) in mouse ovaries from damage induced by cyclophosphamide with 65% to 86% PMF survival compared to 46% PMF survival with a saline control. Formulations containing cetrorelix have been used to prevent ovulation during in vitro fertilization.

Uses

Cetrorelix, a luteinizing hormone releasing hormone receptor (LHRHR) antagonist, was used to study its safety, mechanism of action, metabolism, and efficacy as a therapeutic agent for the treatment of blood cancers such as multiple myeloma (MM). Cetrorelix is used to evaluate its effects on a wide range of physiological processes and malignancies that involve luteinizing hormone releasing hormone receptor signaling pathways involving processes such as steroidogenesis.

Uses

Cetrorelix Acetate is an gonadotropin-releasing hormone antagonist and is used to treat hormone-sensitive cancers of the prostate and breast.

Definition

ChEBI: The acetic acid salt of cetrorelix. A gonadotrophin-releasing hormone (GnRH) antagonist, it is used for treatment of infertility and of hormone-sensitive cancers of the prostate and breast.

Biochem/physiol Actions

Cetrorelix acetate is a luteinizing hormone releasing hormone receptor antagonist. It causes prepubertal reduction in bone modeling, bone density and bone strength comparable to post-menopausal bone loss.

storage

Store at -20°C

CETRORELIX Preparation Products And Raw materials

Raw materials

Preparation Products

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CETRORELIX Suppliers

Canada 1 China 87 India 5 United Kingdom 1 United States 11 USA 1 Global 106
MedChemexpress LLC
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021-58955995
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609-228-5909
Email
sales@medchemexpress.cn
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United States
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Creative Peptides
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info@creative-peptides.com
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United States
ProdList
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Musechem
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+1-800-259-7612
Fax
+1-800-259-7612
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info@musechem.com
Country
United States
ProdList
4660
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TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32161
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58
BOC Sciences
Tel
16314854226; +16314854226
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inquiry@bocsci.com
Country
United States
ProdList
19741
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58
InvivoChem
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+1-708-310-1919 +1-13798911105
Fax
708-557-7486
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sales@invivochem.cn
Country
United States
ProdList
6391
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58
TargetMol Chemicals Inc.
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support@targetmol.com
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United States
ProdList
38631
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58
NE Scientific
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United States
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5030
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55
Cayman Chemical Company
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cayman@caymanchem.com
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United States
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6213
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MedChemExpress
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United States
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6398
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Riedel-de Haen AG
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United States
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View Lastest Price from CETRORELIX manufacturers

Shandong Huizhihan Supply Chain Co., Ltd
Product
Cetrorelix 145672-81-7
Price
US $0.00-0.00/box
Min. Order
1box
Purity
99%
Supply Ability
1000
Release date
2024-10-31
Longyan Tianhua Biological Technology Co., Ltd
Product
CETRORELIX 145672-81-7
Price
US $15.00/g
Min. Order
1Kg/Bag
Purity
99%
Supply Ability
20 Tons
Release date
2020-10-27
Career Henan Chemical Co
Product
CETRORELIX 145672-81-7
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100kG
Release date
2019-07-04

145672-81-7, CETRORELIXRelated Search:

CETRORELIX CETRORELIX cetrorelix Acetylated cetrorelix NA CETRORELIX ACETATE (Sitraric Acetate) Deamidated cetrorelix AC-(D-ALA[3-(2-NAPHTHYL)])-[D-PHE(4-CL)]-(D-ALA[3-(3-PYRIDYL)])-SER-TYR-(D-CIT)-LEU-ARG-PRO-D-ALA-NH2, ACETATE Cetrorelix trifluoroacetate Cetrorelix acetate Cetrorelix acetate

  • D 20761
  • D-Alaninamide, N-acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-L-tyrosyl-N5-(aminocarbonyl)-D-ornithyl-L-leucyl-L-arginyl-L-prolyl-, acetate (salt)
  • Ns 75a
  • Sb 075 acetate
  • Cetrorelix Acetate,SB-075 acetate,NS-75A, >98%
  • Cetrorelix impurity
  • SB-075 ACETATE;NS-75A
  • Cetrotid
  • Ovurelix
  • N-acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-L-tyrosyl-N5-(aminocarbonyl)-D-ornithyl-L-leucyl-L-arginyl-L-prolyl-D-alaninamide acetic acid salt
  • Cetrorelix( x acetate)
  • Cetrorelix acetate (SB-75)
  • Cetrorelix AcetateQ: What is Cetrorelix Acetate Q: What is the CAS Number of Cetrorelix Acetate Q: What is the storage condition of Cetrorelix Acetate Q: What are the applications of Cetrorelix Acetate
  • SB-75,GnRH Receptor,Cetrorelix Acetate,Inhibitor,SB 75,Gonadotropin releasing hormone receptor,inhibit,SB75,GNRHR
  • (S)-N-((R)-1-Amino-1-oxopropan-2-yl)-1-((2S,5S,8R,11S,14S,17R,20R,23R)-20-(4-chlorobenzyl)-2-(3-guanidinopropyl)-11-(4-hydroxybenzyl)-14-(hydroxymethyl)-5-isobutyl-23-(naphthalen-2-ylmethyl)-4,7,10,13,16,19,22,25-octaoxo-17-(pyridin-3-ylmethyl)-8-(3-ureid
  • Cetrorelix Acetate, 10 mM in DMSO
  • 145672-81-7
  • C70H92ClN17O14xC2H4O2
  • Amines, Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals