4-(4-AMINO-3-FLUOROPHENOXY)-N-METHYLPICOLINAMIDE

Product Name: 4-(4-AMINO-3-FLUOROPHENOXY)-N-METHYLPICOLINAMIDE
CAS No.: 757251-39-1
Chemical Name: 4-(4-AMINO-3-FLUOROPHENOXY)-N-METHYLPICOLINAMIDE
Synonyms: RG-M2;Regofenib impurity 4;Regorafenib USP RC A;Regorafenib Impurity 35;Regorafenib Intermediate;Regorafenib EP Impurity A;4-(4-amino-3-fluorophenoxy);1,3-dimethyl-35-nitrosourea;Regorafenib Related Compound A;AFP-Picolin Methylamide Impurity
CBNumber: CB51486673
Molecular Formula: C13H12FN3O2
Formula Weight: 261.25
MOL File: 757251-39-1.mol

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4-(4-AMINO-3-FLUOROPHENOXY)-N-METHYLPICOLINAMIDE Property

Melting point:: 143 °C
Boiling point:: 459.8±45.0 °C(Predicted)
Density: 1.305
vapor pressure: 0Pa at 20℃
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Chloroform (Slightly), DMSO (Sparingly), Methanol (Slightly)
form: Solid
pka: 13.92±0.46(Predicted)
color: Orange to Dark Red to Brown
Water Solubility: 190mg/L at 20℃
InChI: InChI=1S/C13H12FN3O2/c1-16-13(18)12-7-9(4-5-17-12)19-8-2-3-11(15)10(14)6-8/h2-7H,15H2,1H3,(H,16,18)
InChIKey: ZQHJPIPGBODVTG-UHFFFAOYSA-N
SMILES: C1(C(NC)=O)=NC=CC(OC2=CC=C(N)C(F)=C2)=C1
LogP: 1.3 at 25℃

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Safety

HS Code: 2933.39.9200

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: Y0002093
Product name: Regorafenib impurity A
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: 15 mg
Price: $118
Updated: 2025/07/31

Sigma-Aldrich

Product number: 1600212
Product name: Regorafenib Related Compound A
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 15mg
Price: $986
Updated: 2025/07/31

Sigma-Aldrich

Product number: Y0002093
Product name: Regorafenib impurity A
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: Y0002093
Price: $150
Updated: 2024/03/01

TCI Chemical

Product number: A2979
Product name: 4-(4-Amino-3-fluorophenoxy)-N-methyl-2-pyridinecarboxamide
Purity: >98.0%(HPLC)
Packaging: 200mg
Price: $33
Updated: 2025/07/31

TCI Chemical

Product number: A2979
Product name: 4-(4-Amino-3-fluorophenoxy)-N-methyl-2-pyridinecarboxamide
Purity: >98.0%(HPLC)
Packaging: 1g
Price: $99
Updated: 2025/07/31

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4-(4-AMINO-3-FLUOROPHENOXY)-N-METHYLPICOLINAMIDE Chemical Properties,Usage,Production

Chemical Properties

4-(4-Amino-3-fluorophenoxy)-N-methylpicolinamide has the appearance of a white to yellow powder or crystals, which is stable and non-reactive under normal conditions of use, storage and transport.

Uses

4-(4-Amino-3-fluorophenoxy)-N-methylpyridine-2-carboxamide is a compound used as a reagent to synthesize Regorafenib (R143000), a multikinase inhibitor that is used to treat patients with advanced colorectal cancer.

Definition

ChEBI: 4-(4-Amino-3-fluorophenoxy)-N-methyl-2-pyridinecarboxamide is an aromatic ether.

Synthesis

399-95-1

220000-87-3

757251-39-1

Under nitrogen atmosphere, 363 g of 4-amino-3-fluorophenol, 374 g of 4-chloro-N-methylpyridine-2-carboxamide and 3740 mL of N,N-dimethylacetamide were sequentially added to the reaction vessel and stirred until completely dissolved. Subsequently, 115 g of sodium hydroxide was added and the temperature of the reaction system was raised to 105 °C and the temperature was maintained for 1 hour. Upon completion of the reaction, 5600 mL of water was added to the system, the mixture was cooled to 10 °C and stirred at this temperature overnight to promote crystallization. After separation by filtration, 509 g of the brown solid product 4-(4-amino-3-fluorophenoxy)-N-methylpyridine-2-carboxamide was obtained by drying. The product was analyzed by high performance liquid chromatography (HPLC) and showed a purity of 99.3%, a melting point of 141.5-142.5 °C and a yield of 88.9%.

References

[1] Patent: CN108997209, 2018, A. Location in patent: Paragraph 0024; 0025; 0027; 0029; 0031; 0033; 0035
[2] Patent: US2017/334856, 2017, A1. Location in patent: Paragraph 0036
[3] Bioorganic and Medicinal Chemistry Letters, 2018, vol. 28, # 4, p. 577 - 583
[4] Patent: CN104592105, 2017, B. Location in patent: Paragraph 0227; 0228; 0229; 0230; 0233-0235; 0238-0241
[5] Patent: US2008/90856, 2008, A1. Location in patent: Page/Page column 34

4-(4-AMINO-3-FLUOROPHENOXY)-N-METHYLPICOLINAMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-(4-AMINO-3-FLUOROPHENOXY)-N-METHYLPICOLINAMIDE Suppliers

Americas 1 China 234 Europe 1 India 13 Japan 1 Switzerland 1 United Kingdom 1 United States 13 Global 265

Yangzhou QinYuan Pharmaceutical Co., Ltd.

Tel: 0514-80939770 13773367191
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Chemsky（shanghai）International Co.,Ltd.

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Jinan Trio PharmaTech Co., Ltd.

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S.Z. PhyStandard Bio-Tech. Co., Ltd.

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Tianjin Branch Chong pharmaceutical intermediates Co., Ltd.

Tel: 022-60116533 13207668525
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View Lastest Price from 4-(4-AMINO-3-FLUOROPHENOXY)-N-METHYLPICOLINAMIDE manufacturers

Hubei Lidu New Material Technology Co., Ltd

Product: 4-(4-Amino-3-fluorophenoxy)-N-methylpicolinamide 757251-39-1
Price: US $0.00-0.00/g
Min. Order: 1g
Purity: 98%
Supply Ability: 20 tons
Release date: 2025-07-24

LY Global chemicals co.,ltd .

Product: 4-(4-AMINO-3-FLUOROPHENOXY)-N-METHYLPICOLINAMIDE 757251-39-1
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98.0%min
Supply Ability: 100kg
Release date: 2023-03-11

Shanghai Rlavie Technology Co ltd

Product: 4-(4-Amino-3-fluorophenoxy)-N-methylpyridine-2-carboxamide 757251-39-1
Price: US $0.00-0.00/G
Min. Order: 1G
Purity: 98%min
Supply Ability: 50kgs/month
Release date: 2022-09-11

757251-39-1, 4-(4-AMINO-3-FLUOROPHENOXY)-N-METHYLPICOLINAMIDERelated Search:

1,3-Benzenediol, 5-fluoro-4-nitro- 4-(4-Fluorophenyl)-1-Methyl- Paroxetine Selexipag Impurity 6 (4-BENZYLOXYCARBONYLAMINOPHENYL)BORONIC ACID, PINACOL ESTER PAROXETINE RELATED COMPOUND C (15 MG) ((+)-TRANS-PAROXETINE HYDROCHLORIDE) S-Silodosin 6,6'-bis(2-methyl-2H-tetrazol-5-yl)-3,3'-bipyridine 2-[(4,6-Dimethyl-2-pyrimidinyl)oxy]-3,3-diphenyl-2-propenoic Acid Cabozantinib Impurity E 4-Amino-3-fluorophenol 4-[4-[[[[4-Chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluorophenoxy]-N-methyl-2-pyridinecarboxamide hydrate 4-Chloro-alpha,alpha,alpha-trifluoro-m-toluidine Regorafenib Regorafenib iMpurity Benzene, 1-chloro-3-isocyanato-5-(trifluoromethyl)- 2-Pyridinecarboxylic acid, 4,5,6-trichloro-, methyl ester 1,3-Benzenediol, 4-amino-5-fluoro-

4-(4-AMINO-3-FLUOROPHENOXY)-N-METHYLPICOLINAMIDE

2-Pyridinecarboxamide,4-(4-amino-3-fluorophenoxy)-N-methyl-

4-(4-Amino-3-fluorophenoxy)pyridine-2-carboxylic acid methylamine

4-(4-amino-3-fluorophenoxy)

4-(4-amino-3-fluorophenoxy)-N-methylpyridine-2-carboxamid

Regorafenib Impurity 35

4-(4-Amino-3-fluorophenoxy)pyridine-2-carboxylic acid methylamide

4-(4-Amino-3-fluorophenoxy)-N-methylpyridine-2-carboxamide

4-(4-AMINO-3-FLUOROPHENOXY)-N-METHYL-2-PYRIDINECARBOXAMIDE

4-(4-Amino-3-fluorophenoxy)-N-methylpicolinamide EINECS

4-(4-AMINO-3-FLUOROPHENOXY)-N-METHYLPICOLIMIDE

Regorafenib Intermediate

Regofenib impurity 4

AFP-Picolin Methylamide Impurity

Regorafenib USP RC A

Regorafenib EP Impurity A

AFP-Picolin Methylamide ImpurityQ: What is AFP-Picolin Methylamide Impurity Q: What is the CAS Number of AFP-Picolin Methylamide Impurity Q: What is the storage condition of AFP-Picolin Methylamide Impurity Q: What are the applications of AFP-Picolin Methylamide Impurity

RG-M2

Regorafenib EP Impurity A (Regorafenib USP Related Compound A)

4- (4-Amino-3-fluorophenoxy) - N-methyl-2-pyridylformamide

1,3-dimethyl-35-nitrosourea

Regorafenib Related Compound A

5-(4-amino-3-fluorophenoxy)-4-chloro-N-methylpicolinamide

757251-39-1

797251-39-1

Regorafenib