METHYL CARBAMOYLACETATE
- Product Name
- METHYL CARBAMOYLACETATE
- CAS No.
- 51513-29-2
- Chemical Name
- METHYL CARBAMOYLACETATE
- Synonyms
- SKL247;METHYL MALONAMATE;Methylmalonamate,98%;Pramexol Impurity 68;METHYL CARBAMOYLACETATE;METHYL MALONATE MONOAMIDE;Methyl 3-aMino-3-oxopropanoate;Methyl 3-Amino-3-oxopropionate;malonic acid monomethyl ester monoamide;3-Amino-3-oxo-propanoic acid methyl ester
- CBNumber
- CB5149564
- Molecular Formula
- C4H7NO3
- Formula Weight
- 117.1
- MOL File
- 51513-29-2.mol
METHYL CARBAMOYLACETATE Property
- Melting point:
- 39-44 °C
- Boiling point:
- 263.7±23.0 °C(Predicted)
- Density
- 1.184±0.06 g/cm3(Predicted)
- storage temp.
- Store at room temperature
- pka
- 13.51±0.46(Predicted)
- form
- solid
- Appearance
- White to off-white Solid
- BRN
- 2237801
- InChI
- InChI=1S/C4H7NO3/c1-8-4(7)2-3(5)6/h2H2,1H3,(H2,5,6)
- InChIKey
- LSNSJCKGQREPDW-UHFFFAOYSA-N
- SMILES
- C(OC)(=O)CC(N)=O
Safety
- Safety Statements
- 22-24/25
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 63407
- Product name
- Methyl malonate monoamide
- Purity
- ≥97.0% (HPLC)
- Packaging
- 10g
- Price
- $140
- Updated
- 2025/07/31
- Product number
- M219788
- Product name
- Methyl3-Amino-3-oxopropanoate
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- CHM1047922
- Product name
- METHYL MALONATE MONOAMIDE
- Purity
- 95.00%
- Packaging
- 10G
- Price
- $1202.92
- Updated
- 2021/12/16
- Product number
- CD13011894
- Product name
- Methyl3-amino-3-oxopropanoate
- Purity
- 97%
- Packaging
- 5g
- Price
- $84
- Updated
- 2021/12/16
- Product number
- CD13011894
- Product name
- Methyl3-amino-3-oxopropanoate
- Purity
- 97%
- Packaging
- 10g
- Price
- $149
- Updated
- 2021/12/16
METHYL CARBAMOYLACETATE Chemical Properties,Usage,Production
Synthesis
3196-73-4
814-49-3
51513-29-2
The general procedure for the synthesis of methylmalonamide from methyl 3-aminopropionate hydrochloride and diethyl chlorophosphate is as follows: Example 10: Synthesis of 2-methoxycarbonyl ethylamides of monoacetic acid A 1. Monic acid A (1.72 g; 5 mM) was dissolved in THF (40 ml). 2. Triethylamine (0.7 ml; 5 mM) and diethyl chlorophosphate (0.85 g; 5 mM) were added and the reaction was stirred under argon protection for 3 hours. 3. The resulting triethylamine hydrochloride precipitate was removed by filtration. 4. To the filtrate, aqueous THF solution (50%; 40 ml) of β-alanine methyl ester hydrochloride (0.7 g; 5 mM) and triethylamine (0.7 ml) were added and the reaction was stirred at room temperature overnight. 5. After completion of the reaction, the reaction solution was evaporated to dryness. 6. The residue was dissolved in water (20 ml), washed with saturated brine and extracted with ethyl acetate (5 x 40 ml). 7. The ethyl acetate extracts were combined, dried with anhydrous MgSO4 and evaporated to dryness to give an oil. 8. Purification by silica gel column chromatography (Type 60, 30 g) gave the target product as an oil (0.335 g; 16% yield). The characterization data of the product were as follows: νmax (CDCl3) 3420, 3000, 1730, 1665, 1635 cm-1; λmax (EtOH) 222 nm (εm 14,790). δH (CDCl3) 6.47 (1H, t, NH), 5.65 (1H, s, C2-H), 3.67 (3H, s, -CO2CH3), 2.11 (3H, s, C15-CH3), 1.20 (3H, d, C14-CH3), 0.91 (3H, d, C17-CH3). δC (CDCl3) 173.0 (C1'), 167.6 (C1), 151.3 (C3), 120.0 (C2), 75.1 (C5), 70.8 (C13), 70.5 (C7), 69.0 (C6), 65.4 (C16), 60.9 (C11), 55.7 (C10), 51.8 (OMe), 42.7 (C4, C12), 39.8 (C8), 34.9 (C3'), 34.0 (C2'), 31.8 (C9), 20.7 (C7), 18.8 (C15), 12.5 (C17).
References
[1] Patent: US4200635, 1980, A
METHYL CARBAMOYLACETATE Preparation Products And Raw materials
Raw materials
Preparation Products
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