Ethyl malonyl hydrazide
- Product Name
- Ethyl malonyl hydrazide
- CAS No.
- 30866-24-1
- Chemical Name
- Ethyl malonyl hydrazide
- Synonyms
- Nsc75205;N1-Ethylmalonohydrazide;Ethyl malonyl hydrazine;ETHYL MALONYL HYDRAZIDE;ETHYL 3-HYDRAZINO-3-OXOPROPIONATE;Ethyl 3-oxo-3-hydrazino-propionate;ethyl 2-(hydrazinecarbonyl)acetate;ethyl 3-hydrazinyl-3-oxopropanoate;Ethyl 3-hydrazino-3-oxopropionate 97%;Propanedioic acid, 1-ethyl ester, 3-hydrazide
- CBNumber
- CB1441037
- Molecular Formula
- C5H10N2O3
- Formula Weight
- 146.14
- MOL File
- 30866-24-1.mol
Ethyl malonyl hydrazide Property
- Melting point:
- 72-75 °C (lit.)
- Boiling point:
- 320.9±25.0 °C(Predicted)
- Density
- 1.176±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- form
- solid
- pka
- 12.02±0.35(Predicted)
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C5H10N2O3/c1-2-10-5(9)3-4(8)7-6/h2-3,6H2,1H3,(H,7,8)
- InChIKey
- HCPOCMMGKBZWSJ-UHFFFAOYSA-N
- SMILES
- C(C(=O)NN)C(=O)OCC
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 222805
- Product name
- N1-Ethylmalonohydrazide
- Purity
- 97%
- Packaging
- 1g
- Price
- $18
- Updated
- 2021/12/16
- Product number
- 9988AL
- Product name
- Ethyl 3-hydrazino-3-oxopropionate
- Packaging
- 5g
- Price
- $117
- Updated
- 2021/12/16
- Product number
- 4148-1-45
- Product name
- Ethyl 3-hydrazino-3-oxopropionate
- Packaging
- 1g
- Price
- $136
- Updated
- 2021/12/16
- Product number
- 9988AL
- Product name
- Ethyl 3-hydrazino-3-oxopropionate
- Packaging
- 10g
- Price
- $164
- Updated
- 2021/12/16
- Product number
- 9988AL
- Product name
- Ethyl 3-hydrazino-3-oxopropionate
- Packaging
- 100g
- Price
- $644
- Updated
- 2021/12/16
Ethyl malonyl hydrazide Chemical Properties,Usage,Production
Uses
Ethyl 3-hydrazino-3-oxopropionate may be used in the following studies:
- As starting reagent in the step-wise construction of complex pyrrole-pyrazole system.,
- Synthesis of 4,5-dihydro-1H-pyrazoles, via reaction with 4-alkoxy-1,1,1-trifluoro-3-alken-2-ones, using conventional thermal heating method and a microwave-assisted method.
- Synthesis of pyrazolopyridazine.
Synthesis
105-53-3
30866-24-1
General procedure for the synthesis of ethyl 3-oxo-3-hydrazinopropionate from diethyl malonate: diethyl malonate (10 g, 62.5 mmol) was dissolved in 50 ml of anhydrous ethanol, followed by slow addition of 85% hydrazine hydrate (1.44 g, 1.44 mol). The reaction mixture was stirred and reacted at room temperature overnight. After completion of the reaction, filtration was carried out and the filtrate was collected. The solvent was removed by distillation under reduced pressure to give the crude product. The crude product was purified by recrystallization with a mixed solvent of ethyl acetate/petroleum ether to finally obtain the target compound ethyl 3-oxo-3-hydrazinopropionate (2.10 g, 64% yield) as a white solid.
References
[1] Patent: CN107629014, 2018, A. Location in patent: Paragraph 0016; 0017
[2] European Journal of Medicinal Chemistry, 2008, vol. 43, # 3, p. 584 - 594
[3] Liebigs Annalen der Chemie, 1990, # 9, p. 841 - 846
[4] European Journal of Medicinal Chemistry, 2013, vol. 70, p. 358 - 363
[5] Chinese Chemical Letters, 2017, vol. 28, # 5, p. 1031 - 1034
Ethyl malonyl hydrazide Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Ethyl malonyl hydrazide manufacturers
- Product
- Ethyl malonyl hydrazide 30866-24-1
- Price
- US $1.00/Kg
- Min. Order
- 1Kg
- Purity
- 98%
- Supply Ability
- 20T
- Release date
- 2024-07-22
- Product
- Ethyl malonyl hydrazide 30866-24-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1000KGS
- Release date
- 2020-01-02