ChemicalBook > CAS DataBase List > Ethyl malonyl hydrazide

Ethyl malonyl hydrazide

Product Name: Ethyl malonyl hydrazide
CAS No.: 30866-24-1
Chemical Name: Ethyl malonyl hydrazide
Synonyms: Nsc75205;N1-Ethylmalonohydrazide;Ethyl malonyl hydrazine;ETHYL MALONYL HYDRAZIDE;ETHYL 3-HYDRAZINO-3-OXOPROPIONATE;Ethyl 3-oxo-3-hydrazino-propionate;ethyl 2-(hydrazinecarbonyl)acetate;ethyl 3-hydrazinyl-3-oxopropanoate;Ethyl 3-hydrazino-3-oxopropionate 97%;Propanedioic acid, 1-ethyl ester, 3-hydrazide
CBNumber: CB1441037
Molecular Formula: C5H10N2O3
Formula Weight: 146.14
MOL File: 30866-24-1.mol

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Ethyl malonyl hydrazide Property

Melting point:: 72-75 °C (lit.)
Boiling point:: 320.9±25.0 °C(Predicted)
Density: 1.176±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
form: solid
pka: 12.02±0.35(Predicted)
Appearance: White to off-white Solid
InChI: InChI=1S/C5H10N2O3/c1-2-10-5(9)3-4(8)7-6/h2-3,6H2,1H3,(H,7,8)
InChIKey: HCPOCMMGKBZWSJ-UHFFFAOYSA-N
SMILES: C(C(=O)NN)C(=O)OCC

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-37/39
WGK Germany: 3
HS Code: 2928009090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Oakwood

Product number: 222805
Product name: N1-Ethylmalonohydrazide
Purity: 97%
Packaging: 1g
Price: $18
Updated: 2021/12/16

AK Scientific

Product number: 9988AL
Product name: Ethyl 3-hydrazino-3-oxopropionate
Packaging: 5g
Price: $117
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4148-1-45
Product name: Ethyl 3-hydrazino-3-oxopropionate
Packaging: 1g
Price: $136
Updated: 2021/12/16

AK Scientific

Product number: 9988AL
Product name: Ethyl 3-hydrazino-3-oxopropionate
Packaging: 10g
Price: $164
Updated: 2021/12/16

AK Scientific

Product number: 9988AL
Product name: Ethyl 3-hydrazino-3-oxopropionate
Packaging: 100g
Price: $644
Updated: 2021/12/16

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Ethyl malonyl hydrazide Chemical Properties,Usage,Production

Uses

Ethyl 3-hydrazino-3-oxopropionate may be used in the following studies:

As starting reagent in the step-wise construction of complex pyrrole-pyrazole system.,
Synthesis of 4,5-dihydro-1H-pyrazoles, via reaction with 4-alkoxy-1,1,1-trifluoro-3-alken-2-ones, using conventional thermal heating method and a microwave-assisted method.
Synthesis of pyrazolopyridazine.

Synthesis

105-53-3

30866-24-1

General procedure for the synthesis of ethyl 3-oxo-3-hydrazinopropionate from diethyl malonate: diethyl malonate (10 g, 62.5 mmol) was dissolved in 50 ml of anhydrous ethanol, followed by slow addition of 85% hydrazine hydrate (1.44 g, 1.44 mol). The reaction mixture was stirred and reacted at room temperature overnight. After completion of the reaction, filtration was carried out and the filtrate was collected. The solvent was removed by distillation under reduced pressure to give the crude product. The crude product was purified by recrystallization with a mixed solvent of ethyl acetate/petroleum ether to finally obtain the target compound ethyl 3-oxo-3-hydrazinopropionate (2.10 g, 64% yield) as a white solid.

References

[1] Patent: CN107629014, 2018, A. Location in patent: Paragraph 0016; 0017
[2] European Journal of Medicinal Chemistry, 2008, vol. 43, # 3, p. 584 - 594
[3] Liebigs Annalen der Chemie, 1990, # 9, p. 841 - 846
[4] European Journal of Medicinal Chemistry, 2013, vol. 70, p. 358 - 363
[5] Chinese Chemical Letters, 2017, vol. 28, # 5, p. 1031 - 1034

Ethyl malonyl hydrazide Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Ethyl malonyl hydrazide manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Ethyl malonyl hydrazide 30866-24-1
Price: US $1.00/Kg
Min. Order: 1Kg
Purity: 98%
Supply Ability: 20T
Release date: 2024-07-22

Career Henan Chemical Co

Product: Ethyl malonyl hydrazide 30866-24-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1000KGS
Release date: 2020-01-02

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ETHYL MALONYL HYDRAZIDE

ETHYL 3-HYDRAZINO-3-OXOPROPIONATE

Ethyl 3-oxo-3-hydrazino-propionate

Nsc75205

ethyl 3-hydrazinyl-3-oxopropanoate

Ethyl 3-hydrazino-3-oxopropionate 97%

Ethyl malonyl hydrazine

N1-Ethylmalonohydrazide

ethyl 2-(hydrazinecarbonyl)acetate

Propanedioic acid, 1-ethyl ester, 3-hydrazide

Ethyl 3-<WBR>hydrazino-<WBR>3-<WBR>oxopropionate

30866-24-1

H2NNHCOCH2CO2C2H5

Building Blocks

Carbonyl Compounds

ESTER

Organic Building Blocks

Hydrazides