5-BROMO-2-(DIMETHYLAMINO)PYRAZINE
- Product Name
- 5-BROMO-2-(DIMETHYLAMINO)PYRAZINE
- CAS No.
- 446286-94-8
- Chemical Name
- 5-BROMO-2-(DIMETHYLAMINO)PYRAZINE
- Synonyms
- 2-BROMO-5-DIMETHYLAMINOPYRAZINE;5-BROMO-2-(DIMETHYLAMINO)PYRAZINE;(5-BROMO-2-PYRAZINYL)DIMETHYLAMINE;5-bromo-N,N-dimethylpyrazin-2-amine;2-Pyrazinamine, 5-bromo-N,N-dimethyl-;(5-BroMo-pyrazin-2-yl)-diMethyl-aMine
- CBNumber
- CB51504058
- Molecular Formula
- C6H8BrN3
- Formula Weight
- 202.05
- MOL File
- 446286-94-8.mol
5-BROMO-2-(DIMETHYLAMINO)PYRAZINE Property
- Boiling point:
- 265.2±35.0 °C(Predicted)
- Density
- 1.553±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 1.74±0.10(Predicted)
- Appearance
- Light yellow to yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- FB139368
- Product name
- 5-Bromo-N,N-dimethylpyrazin-2-amine
- Packaging
- 500mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- FB139368
- Product name
- 5-Bromo-N,N-dimethylpyrazin-2-amine
- Packaging
- 1g
- Price
- $91
- Updated
- 2021/12/16
- Product number
- FB139368
- Product name
- 5-Bromo-N,N-dimethylpyrazin-2-amine
- Packaging
- 2g
- Price
- $158
- Updated
- 2021/12/16
- Product number
- FB139368
- Product name
- 5-Bromo-N,N-dimethylpyrazin-2-amine
- Packaging
- 5G
- Price
- $316
- Updated
- 2021/12/16
- Product number
- HCH0356231
- Product name
- (5-BROMO-2-PYRAZINYL)DIMETHYLAMINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $503.05
- Updated
- 2021/12/16
5-BROMO-2-(DIMETHYLAMINO)PYRAZINE Chemical Properties,Usage,Production
Synthesis
59489-71-3
74-88-4
446286-94-8
2-Amino-5-bromopyrazine (1,170 mg, 6.72 mmol) was dissolved in tetrahydrofuran (THF, 100 mL) and iodomethane (CH3I, 1.2 mL, 19.5 mmol) was added. The reaction mixture was cooled to 0 °C, 60% sodium hydride (NaH, 1.5 g, 37.5 mmol) was added slowly and stirred at this temperature for 5 hours. Upon completion of the reaction, a small amount of methanol was added to quench the excess sodium hydride, followed by the addition of water (10 mL). The reaction mixture was extracted with ethyl acetate (3 x 200 mL), the organic layers were combined and dried over anhydrous sodium sulfate. The organic layer was concentrated under reduced pressure and the resulting crude product was purified by column chromatography [silica gel 48.5 g; eluent: hexane-ethyl acetate (1:1)] to afford 5-bromo-2-(dimethylamino)pyrazine (1,096 mg, 5.4 mmol, 80% yield) as a light yellow powdery solid.
References
[1] Patent: JP2015/193584, 2015, A. Location in patent: Paragraph 0080; 0081
5-BROMO-2-(DIMETHYLAMINO)PYRAZINE Preparation Products And Raw materials
Raw materials
Preparation Products
5-BROMO-2-(DIMETHYLAMINO)PYRAZINE Suppliers
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