7-CHLOROPYRAZOLO[1,5-A]PYRIMIDINE
Uses- Product Name
- 7-CHLOROPYRAZOLO[1,5-A]PYRIMIDINE
- CAS No.
- 58347-49-2
- Chemical Name
- 7-CHLOROPYRAZOLO[1,5-A]PYRIMIDINE
- Synonyms
- 7-CHLOROPYRAZOLO[1,5-A]PYRIMIDINE;Pyrazolo[1,5-a]pyrimidine, 7-chloro-
- CBNumber
- CB51517825
- Molecular Formula
- C6H4ClN3
- Formula Weight
- 153.57
- MOL File
- 58347-49-2.mol
7-CHLOROPYRAZOLO[1,5-A]PYRIMIDINE Property
- Melting point:
- 96-98℃
- Density
- 1.51
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- Powder
- pka
- -0.59±0.40(Predicted)
- color
- Off-white to yellow to pink to brown
- InChI
- InChI=1S/C6H4ClN3/c7-5-1-3-8-6-2-4-9-10(5)6/h1-4H
- InChIKey
- YCZQHXPIKQHABJ-UHFFFAOYSA-N
- SMILES
- C12=CC=NN1C(Cl)=CC=N2
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P363Wash contaminated clothing before reuse.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- C381290
- Product name
- 7-Chloropyrazolo[1,5-a]pyrimidine
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 295673
- Product name
- 7-Chloropyrazolo[1,5-a]pyrimidine
- Packaging
- 100mg
- Price
- $369
- Updated
- 2021/12/16
- Product number
- 3H32-5-GY
- Product name
- 7-Chloropyrazolo[1,5-a]pyrimidine
- Purity
- 97%
- Packaging
- 5G
- Price
- $384
- Updated
- 2021/12/16
- Product number
- 38130
- Product name
- 7-Chloropyrazolo[1,5-α]pyrimidine
- Purity
- 95+%
- Packaging
- 1g
- Price
- $395
- Updated
- 2021/12/16
- Product number
- FC57422
- Product name
- 7-Chloropyrazolo[1,5-a]pyrimidine
- Packaging
- 5G
- Price
- $420
- Updated
- 2021/12/16
7-CHLOROPYRAZOLO[1,5-A]PYRIMIDINE Chemical Properties,Usage,Production
Uses
7-Clopizo[1,5-A]pyrimidine is a heterocyclic organic compound that can be used as an organic intermediate.
Synthesis
29274-23-5
58347-49-2
Pyrazolo[1,5-a]pyrimidin-7(4H)-one (0.50 g, 3.70 mmol) was added with phosphorus trichloride (0.88 mL, 9.62 mmol) and diisopropylethylamine (DIEA, 0.13 mL, 0.74 mmol), mixed well and then the reaction was stirred at 90 °C overnight. After completion of the reaction, the reaction mixture was slowly poured into ice water and extracted with dichloromethane, and the extract was washed with brine. The organic phase was dried over anhydrous sodium sulfate, filtered and concentrated in vacuum. The crude product was purified by silica gel column chromatography (eluent: hexane/ethyl acetate = 9:1) to afford the target compound 7-chloropyrazolo[1,5-a]pyrimidine (83 mg, 71% yield).LRMS (m/z): 154 (M + 1)+.1H NMR (400 MHz, DMSO-d6) δ ppm: 6.93 (d, 1H), 7.43 (d, 1H), 8.37 (d, 1H), 8.37 (d, 1H). 1H), 8.37 (d, 1H), 8.52 (d, 1H).
References
[1] Patent: EP2518071, 2012, A1. Location in patent: Page/Page column 38
[2] Patent: WO2012/146667, 2012, A1. Location in patent: Page/Page column 90
[3] Patent: WO2012/146666, 2012, A1. Location in patent: Page/Page column 160
[4] Patent: WO2007/17678, 2007, A1. Location in patent: Page/Page column 44
[5] Journal of Medicinal Chemistry, 1981, vol. 24, # 5, p. 610 - 613
7-CHLOROPYRAZOLO[1,5-A]PYRIMIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 7-CHLOROPYRAZOLO[1,5-A]PYRIMIDINE manufacturers
- Product
- 7-Chloropyrazolo[1,5-a]pyriMidine 58347-49-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2020-05-15
- Product
- 7-CHLOROPYRAZOLO[1,5-A]PYRIMIDINE 58347-49-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95%
- Supply Ability
- 500kg
- Release date
- 2018-08-19