ChemicalBook > CAS DataBase List > 7-CHLOROPYRAZOLO[1,5-A]PYRIMIDINE

7-CHLOROPYRAZOLO[1,5-A]PYRIMIDINE

Uses

Product Name: 7-CHLOROPYRAZOLO[1,5-A]PYRIMIDINE
CAS No.: 58347-49-2
Chemical Name: 7-CHLOROPYRAZOLO[1,5-A]PYRIMIDINE
Synonyms: 7-CHLOROPYRAZOLO[1,5-A]PYRIMIDINE;Pyrazolo[1,5-a]pyrimidine, 7-chloro-
CBNumber: CB51517825
Molecular Formula: C6H4ClN3
Formula Weight: 153.57
MOL File: 58347-49-2.mol

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7-CHLOROPYRAZOLO[1,5-A]PYRIMIDINE Property

Melting point:: 96-98℃
Density: 1.51
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: Powder
pka: -0.59±0.40(Predicted)
color: Off-white to yellow to pink to brown
InChI: InChI=1S/C6H4ClN3/c7-5-1-3-8-6-2-4-9-10(5)6/h1-4H
InChIKey: YCZQHXPIKQHABJ-UHFFFAOYSA-N
SMILES: C12=CC=NN1C(Cl)=CC=N2

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P363Wash contaminated clothing before reuse.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: C381290
Product name: 7-Chloropyrazolo[1,5-a]pyrimidine
Packaging: 50mg
Price: $45
Updated: 2021/12/16

Usbiological

Product number: 295673
Product name: 7-Chloropyrazolo[1,5-a]pyrimidine
Packaging: 100mg
Price: $369
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H32-5-GY
Product name: 7-Chloropyrazolo[1,5-a]pyrimidine
Purity: 97%
Packaging: 5G
Price: $384
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 38130
Product name: 7-Chloropyrazolo[1,5-α]pyrimidine
Purity: 95+%
Packaging: 1g
Price: $395
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC57422
Product name: 7-Chloropyrazolo[1,5-a]pyrimidine
Packaging: 5G
Price: $420
Updated: 2021/12/16

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7-CHLOROPYRAZOLO[1,5-A]PYRIMIDINE Chemical Properties,Usage,Production

Uses

7-Clopizo[1,5-A]pyrimidine is a heterocyclic organic compound that can be used as an organic intermediate.

Synthesis

29274-23-5

58347-49-2

Pyrazolo[1,5-a]pyrimidin-7(4H)-one (0.50 g, 3.70 mmol) was added with phosphorus trichloride (0.88 mL, 9.62 mmol) and diisopropylethylamine (DIEA, 0.13 mL, 0.74 mmol), mixed well and then the reaction was stirred at 90 °C overnight. After completion of the reaction, the reaction mixture was slowly poured into ice water and extracted with dichloromethane, and the extract was washed with brine. The organic phase was dried over anhydrous sodium sulfate, filtered and concentrated in vacuum. The crude product was purified by silica gel column chromatography (eluent: hexane/ethyl acetate = 9:1) to afford the target compound 7-chloropyrazolo[1,5-a]pyrimidine (83 mg, 71% yield).LRMS (m/z): 154 (M + 1)+.1H NMR (400 MHz, DMSO-d6) δ ppm: 6.93 (d, 1H), 7.43 (d, 1H), 8.37 (d, 1H), 8.37 (d, 1H). 1H), 8.37 (d, 1H), 8.52 (d, 1H).

References

[1] Patent: EP2518071, 2012, A1. Location in patent: Page/Page column 38
[2] Patent: WO2012/146667, 2012, A1. Location in patent: Page/Page column 90
[3] Patent: WO2012/146666, 2012, A1. Location in patent: Page/Page column 160
[4] Patent: WO2007/17678, 2007, A1. Location in patent: Page/Page column 44
[5] Journal of Medicinal Chemistry, 1981, vol. 24, # 5, p. 610 - 613

7-CHLOROPYRAZOLO[1,5-A]PYRIMIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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7-CHLOROPYRAZOLO[1,5-A]PYRIMIDINE Suppliers

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View Lastest Price from 7-CHLOROPYRAZOLO[1,5-A]PYRIMIDINE manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 7-Chloropyrazolo[1,5-a]pyriMidine 58347-49-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20T
Release date: 2020-05-15

Career Henan Chemical Co

Product: 7-CHLOROPYRAZOLO[1,5-A]PYRIMIDINE 58347-49-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95%
Supply Ability: 500kg
Release date: 2018-08-19

58347-49-2, 7-CHLOROPYRAZOLO[1,5-A]PYRIMIDINERelated Search:

PYRAZOLO[1,5-A]PYRIDIN-3-YLAMINE HYDROCHLORIDE ethyl pyrazolo[1,5-a]pyrazine-3-carboxylate PYRAZOLO[1,5-A]PYRIDIN-3-YLAMINE pyrazolo[1,5-a]pyridin-5-ylMethanol Pyrazolo[1,5-a]pyridine-3-carboxylic acid ETHYL PYRAZOLO[1,5-A]PYRIDINE-3-CARBOXYLATE pyrazolo[1,5-a]pyrazine-3-carboxylic acid Pyrazolo[1,5-a]pyridin-3-amine, hydrochloride (1:1) pyrazolo[1,5-a]pyrazine Pyrazolo[1,5-a]pyriMidin-7-ol 7-CHLORO-3-PHENYL-PYRAZOLO[1,5-A]PYRIMIDINE Pyrazolo[1,5-a]pyridine, 5-(chloromethyl)- Pyrazolo[1,5-a]pyridine-5-methanol Pyrazolo[1,5-a]pyrazin-3-amine 5,7-DICHLOROPYRAZOLO[1,5-A]PYRIMIDINE 8-CHLORO-2-M-TOLYL-6,7-DIHYDRO-5H-CYCLOPENTA[D]-PYRAZOLO[1,5-A]PYRIMIDINE 7-CHLOROPYRAZOLO[1,5-A]PYRIMIDINE 7-CHLORO-2-(4-CHLORO-PHENYL)-5-PHENYL-PYRAZOLO[1,5-A]PYRIMIDINE

7-CHLOROPYRAZOLO[1,5-A]PYRIMIDINE

Pyrazolo[1,5-a]pyrimidine, 7-chloro-

58347-49-2

Heterocycle-Pyrimidine series