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adoprazine

Product Name
adoprazine
CAS No.
222551-17-9
Chemical Name
adoprazine
Synonyms
SLV313;SLV 313;adoprazine;Unii-7snb18Q89d;Adoprazine (SLV313);SLV 313;SLV313;SLV-313;Adoprazine, 10 mM in DMSO;1-(2,3-Dihydro-1,4-benzodioxin-5-yl)-4-[[5-(4-fluorophenyl)-3-pyridinyl]methyl]piperazine;Piperazine, 1-(2,3-dihydro-1,4-benzodioxin-5-yl)-4-[[5-(4-fluorophenyl)-3-pyridinyl]methyl]-;1-(2,3-Dihydrobenzo[b][1,4]dioxin-5-yl)-4-((5-(4-fluorophenyl)pyridin-3-yl)methyl)piperazine
CBNumber
CB51518488
Molecular Formula
C24H24FN3O2
Formula Weight
405.46
MOL File
222551-17-9.mol
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adoprazine Property

Boiling point:
565.0±50.0 °C(Predicted)
Density 
1.256
storage temp. 
Store at -20°C
solubility 
DMSO : 50 mg/mL (123.32 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
form 
Powder
pka
6.07±0.10(Predicted)
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0673
Product name
Adoprazine
Purity
98.10%
Packaging
5mg
Price
$240
Updated
2021/12/16
ChemScene
Product number
CS-0673
Product name
Adoprazine
Purity
98.10%
Packaging
10mg
Price
$408
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
KIN0001417
Product name
ADOPRAZINE
Purity
95.00%
Packaging
5MG
Price
$424.6
Updated
2021/12/16
ChemScene
Product number
CS-0673
Product name
Adoprazine
Purity
98.10%
Packaging
50mg
Price
$1080
Updated
2021/12/16
DC Chemicals
Product number
DC9324
Product name
Adoprazine
Purity
>98%
Packaging
1g
Price
$3600
Updated
2021/12/16
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adoprazine Chemical Properties,Usage,Production

Uses

Adoprazine (SLV313) is a full 5-HT1A receptor agonist with a pEC50 of 9 at cloned h5-HT1A receptors. Adoprazine (SLV313) is a full D2 and D3 receptor antagonist with pA2s of 9.3 and 8.9 at hD2 and hD3 receptors, respectively. Adoprazine (SLV313) has the characteristics of atypical antipsychotics[1].

Biological Activity

Adoprazine (SLV313) is a full agonist at the 5-HT1A receptor with a pEC50 of 9 at the h5-HT1A receptor. Adoprazine (SLV313) is a complete antagonist of D2 and D3 receptors with a pA2 value of 9.3 in hD2 receptor and 8.9 in hD3 receptor. It (SLV313) has atypical antipsychotic properties.

in vitro

Adoprazine (SLV313) has high affinity at human recombinant D 2 , D 3 , D 4 , 5-HT < sub> 2B , and 5-HT 1A receptors, with pK i s of 8.4, 8.4, 8.0, 7.9 and 9.1 , respectively. Adoprazine (SLV313) acts as a high potency dopamine D 2 receptor antagonist and an efficacious serotonin 5-HT 1A receptor agonist, with E max value (% effect of 10 μM 5-HT) of 73 and pK B value of 8.5 .

in vivo

Adoprazine (SLV313) (0.1-10 mg/kg; po; single) is sufficient to reduce extracellular 5-HT and increase dopamine levels in the nucleus accumbens in a dose- and time-dependent manner.

Animal Model: Male Wistar rats (275-350 g)
Dosage: 0.1 mg/kg, 0.3 mg/kg, 1 mg/kg, 3 mg/kg, 10 mg/kg
Administration: po; single
Result : Led to a dose- and time-dependent increase in extracellular levels of DA, DOPAC, and HVA. In contrast, led to a reduction in 5-HT levels and no change in 5-HIAA levels.

target

5-HT 1A Receptor

9 (pEC 50 )

D 2 < /sub> Receptor

9.3 (pA2)

D 3 Receptor

8.9 (pA2)

D 4 Receptor

8.0 (pKi)

5-HT 7 Receptor

7.2 (pKi)

5-HT 1A < /sub> Receptor

9.1 (pKi)

D 2 Receptor

8.4 (pKi)

D 3 Receptor

8.4 (pKi)

IC 50

5-HT1A Receptor: 9 (pEC50); D2 Receptor: 9.3 (pA2); D3 Receptor: 8.9 (pA2); D4 Receptor: 8.0 (pKi); 5-HT7 Receptor: 7.2 (pKi); 5-HT1A Receptor: 9.1 (pKi); D2 Receptor: 8.4 (pKi); D3 Receptor: 8.4 (pKi)

References

[1] Andrew C McCreary, et al. SLV313 (1-(2,3-dihydro-benzo[1,4]dioxin-5-yl)-4- [5-(4-fluoro-phenyl)-pyridin-3-ylmethyl]-piperazine monohydrochloride): a novel dopamine D2 receptor antagonist and 5-HT1A receptor agonist potential antipsychotic drug. Neuropsychopharmacology. 2007 Jan;32(1):78-94. DOI:10.1038/sj.npp.1301098
[2] Liesbeth A Bruins Slot, et al. Differential profile of antipsychotics at serotonin 5-HT1A and dopamine D2S receptors coupled to extracellular signal-regulated kinase. Eur J Pharmacol. 2006 Mar 18;534(1-3):63-70. DOI:10.1016/j.ejphar.2006.01.027

adoprazine Preparation Products And Raw materials

Raw materials

Preparation Products

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adoprazine Suppliers

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222551-17-9, adoprazineRelated Search:

Dibenzothiophene DIBENZAZEPINE Phthalan 1,4-Benzodioxan

  • adoprazine
  • 1-(2,3-Dihydro-1,4-benzodioxin-5-yl)-4-[[5-(4-fluorophenyl)-3-pyridinyl]methyl]piperazine
  • Unii-7snb18Q89d
  • SLV 313
  • SLV313
  • Adoprazine (SLV313)
  • SLV 313;SLV313;SLV-313
  • Piperazine, 1-(2,3-dihydro-1,4-benzodioxin-5-yl)-4-[[5-(4-fluorophenyl)-3-pyridinyl]methyl]-
  • 1-(2,3-Dihydrobenzo[b][1,4]dioxin-5-yl)-4-((5-(4-fluorophenyl)pyridin-3-yl)methyl)piperazine , Adoprazine
  • Adoprazine, 10 mM in DMSO
  • 1-(2,3-Dihydrobenzo[b][1,4]dioxin-5-yl)-4-((5-(4-fluorophenyl)pyridin-3-yl)methyl)piperazine
  • 222551-17-9