rafivirumab
- Product Name
- rafivirumab
- CAS No.
- 944548-37-2
- Chemical Name
- rafivirumab
- Synonyms
- rafivirumab;Research Grade Rafivirumab;Rafivirumab (anti-Rabies virus GP);Research Grade Rafivirumab(DVV03902)
- CBNumber
- CB51518529
- Formula Weight
- 0
- MOL File
- Mol file
rafivirumab Property
- form
- Liquid
- color
- Colorless to light yellow
rafivirumab Chemical Properties,Usage,Production
Uses
Rafivirumab (CR57) is an anti-rabies virus monoclonal antibody for the prophylaxis of rabies. Rafivirumab has neutralizing potency against a broad spectrum of RABV variants. Rafivirumab can be used for research of cocktails[1][2][3].
in vivo
Rafivirumab (3-12 μg/kg,i.m.) together with CR4098 increases survival in syrian hamsters infected with bat rabies viruses[2].
| Animal Model: | Syrian hamsters infected with bat rabies viruses[2]. |
| Dosage: | 6, 12, 16, 18 or 24 μg/kg of CL184 (mixture of Rafivirumab and CR4098 in 1:1 protein ratio) |
| Administration: | i.m. |
| Result: | Increased survival rate. |
References
[1] Kramer RA, et al. The human antibody repertoire specific for rabies virus glycoprotein as selected from immune libraries. Eur J Immunol. 2005 Jul;35(7):2131-45. DOI:10.1002/eji.200526134
[2] Franka R, et al. In Vivo Efficacy of a Cocktail of Human Monoclonal Antibodies (CL184) Against Diverse North American Bat Rabies Virus Variants. Trop Med Infect Dis. 2017 Sep 20;2(3):48. DOI:10.3390/tropicalmed2030048
[3] Ejemel M, et al. A cocktail of human monoclonal antibodies broadly neutralizes North American rabies virus variants as a promising candidate for rabies post-exposure prophylaxis. Sci Rep. 2022 Jun 7;12(1):9403. DOI:10.1038/s41598-022-13527-0
rafivirumab Preparation Products And Raw materials
Raw materials
Preparation Products
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