Diridavumab

Product Name: Diridavumab
CAS No.: 1393659-46-5
Chemical Name: Diridavumab
Synonyms: Diridavumab;Research Grade Diridavumab;Research Grade Diridavumab(DVV03801)
CBNumber: CB68080905
Formula Weight: 0
MOL File: Mol file

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Diridavumab Property

form: Liquid
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

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Diridavumab Chemical Properties,Usage,Production

Uses

Diridavumab is a monoclonal anti-HA stalk antibody. Diridavumab stabilizes the prefusion HA structure and prevents pH-dependent fusion of cellular and viral membranes in endosomes. Diridavumab can be used in research of H2 influenza virus[1].

in vivo

Diridavumab (CR6261; 1.7-15 mg/kg; i.p.; BALB/c mice with H2 influenza virus) protects mice against lethal H2 influenza virus in a dose-dependent manner^[1].

Animal Model:	BALB/c mice with H2 influenza virus^[1]
Dosage:	1.7, 5, or 15 mg/kg
Administration:	Intraperitoneal injection
Result:	Prevented mortality and decreased the percent weight loss. Decreased viral load, altered antigen distribution, and reduced the severity of airway inflammation.

References

[1] Sutton TC, et, al. In Vitro Neutralization Is Not Predictive of Prophylactic Efficacy of Broadly Neutralizing Monoclonal Antibodies CR6261 and CR9114 against Lethal H2 Influenza Virus Challenge in Mice. J Virol. 2017 Nov 30;91(24):e01603-17. DOI:10.1128/JVI.01603-17

Diridavumab Preparation Products And Raw materials

Raw materials

Preparation Products

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Diridavumab Suppliers

China 12 Global 12

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1393659-46-5, DiridavumabRelated Search:

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Diridavumab

Research Grade Diridavumab(DVV03801)

Research Grade Diridavumab

1393659-46-5