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Margetuximab

Product Name
Margetuximab
CAS No.
1350624-75-7
Chemical Name
Margetuximab
Synonyms
Margetuximab;Margetuximab (anti-HER2);Research Grade Margetuximab;Research Grade Margetuximab(DHC09604)
CBNumber
CB98080890
Formula Weight
0
MOL File
Mol file
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Margetuximab Property

storage temp. 
Store at -20°C
form 
Liquid
color 
Colorless to light yellow
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Hazard and Precautionary Statements (GHS)

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Margetuximab Chemical Properties,Usage,Production

Uses

Margetuximab (MGAH22) is a chimeric anti-HER2 monoclonal antibody optimized Fc domain, with an EC50 value of 39.33 ng/mL. Margetuximab can be used for researching metastatic HER2-positive breast cancer[1].

in vivo

Margetuximab (2-4 mg/kg; IP 5 or 6 times at weekly) can firstly and significantly reduces the tumor size at day 30 - 37 in mice model[1]. Margetuximab (15-150 mg/kg; IV; 6 weekly) exhibits well tolerated in cynomolgus monkeys, decreases NK cells by an average of 51%, and induces IL-6 release[1]. Margetuximab (50 mg/kg; IV; single dosage) exhibits favorable safety profile[1]. Pharmacokinetic Parameters of Margetuximab in cynomolgus monkeys[1].

Male, IV (50 mg/kg)Female, IV (50 mg/kg)
Cmax (mg/mL)1.62 ± 0.101.70 ± 0.14
AUC0-￥ (mg·hour/mL)294.1 ± 53.2314.2 ± 31.3
T1/2β (days)9.3 ± 1.89.7 ± 1.1
Clearance (mL/hour)0.43 ± 0.070.40 ± 0.04
VSS (mL)132 ± 2127 ± 8

References

[1] Nordstrom JL, et al. Anti-tumor activity and toxicokinetics analysis of MGAH22, an anti-HER2 monoclonal antibody with enhanced Fcγ receptor binding properties. Breast Cancer Res. 2011;13(6):R123. doi:10.1186/bcr3069

Margetuximab Preparation Products And Raw materials

Raw materials

Preparation Products

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Margetuximab Suppliers

China 15 United States 1 Global 16
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8000
Advantage
62
Guangzhou Hongyuan Chemical Co.,Ltd
Tel
15817493340
Email
981810490@qq.com
Country
China
ProdList
1566
Advantage
58
Wuhan Chemstan Biotechnology Co., Ltd.
Tel
027-65317797 15926423062
Fax
QQ：422450190
Email
422450190@qq.com
Country
China
ProdList
10308
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24961
Advantage
58
Biolab Reagents
Tel
027-65279366 18108604356
Email
products@biolabreagent.com
Country
China
ProdList
9868
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58
Wuhan Jingkangen Biomedical Technology Co., Ltd
Tel
13720134139 086-15871494362 13720134139
Email
orders@jknbiochem.com
Country
China
ProdList
6762
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58
Shanghai Yifei Biotechnology Co. , Ltd.
Tel
021-65675885 18964387627
Email
customer_service@efebio.com
Country
China
ProdList
11973
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58
Shanghai Aladdin Biochemical Technology Co.,Ltd.
Tel
400-6206333 13167063860
Email
anhua.mao@aladdin-e.com
Country
China
ProdList
48457
Advantage
58
Changsha Fuzhen Biotechnology Co.，LTD
Tel
0731-13823398 15111215862
Email
313359644@qq.com
Country
China
ProdList
4161
Advantage
58

1350624-75-7, MargetuximabRelated Search:

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  • Margetuximab
  • Research Grade Margetuximab(DHC09604)
  • Margetuximab (anti-HER2)
  • Research Grade Margetuximab
  • 1350624-75-7