Ganitumab
- Product Name
- Ganitumab
- CAS No.
- 905703-97-1
- Chemical Name
- Ganitumab
- Synonyms
- AMG 479;Ganitumab;Ganitumab 4.92mg/ml;Ganitumab (anti-IGF1R);Research Grade Ganitumab;Research Grade Ganitumab (DHC29902)
- CBNumber
- CB38080757
- Formula Weight
- 0
- MOL File
- Mol file
Ganitumab Property
- form
- Liquid
- color
- Colorless to light yellow
Ganitumab Chemical Properties,Usage,Production
Uses
Ganitumab (AMG 479) is a recombinant human monoclonal antibody to the human type 1 insulin-like growth factor receptor (IGF1R). Ganitumab recognizes murine IGF1R with sub-nanomolar affinity (KD=0.22 nM) and inhibits the interaction of murine IGF1R with IGF1 and IGF2. Ganitumab can be used in research of cancer[1].
in vivo
Ganitumab (AMG 479; 1 mg/dose; i.p; Na?ve and tumor-bearing mice) inhibits IGF1-induced activation of mIGF1R in murine lungs[1].
Ganitumab (300 μg/dose; i.p.; female athymic nude mice) reduces peripheral blood neutrophils[1].
Ganitumab (300 μg/dose; i.p.; male athymic nude mice) causes impaired glucose tolerance in male mice and increases serum levels of mGH, mIGF1 and mIGFBP3[1].
| Animal Model: | Na?ve and tumor-bearing mice[1] |
| Dosage: | 1 mg/dose |
| Administration: | Intraperitoneal injection |
| Result: | Inhibited the IGF1-induced activation of mIGF1R and inhibited 80% tumor growth. |
| Animal Model: | Male athymic nude mice[1] |
| Dosage: | 300 μg/dose |
| Administration: | Intraperitoneal injection, twice per week for a total of five doses |
| Result: | Had significantly higher serum glucose levels than hIgG1-pretreated mice. Increased serum levels of mIGF1, mIGFPB3 and mGH. |
| Animal Model: | Female athymic nude mice[1] |
| Dosage: | 300 μg/dose |
| Administration: | Intraperitoneal injection, twice per week for a total of five doses |
| Result: | Reduced the number of peripheral neutrophils up to 50% compared with hIgG1 controls. |
References
[1] Moody G, et, al. IGF1R blockade with ganitumab results in systemic effects on the GH-IGF axis in mice. J Endocrinol. 2014 Mar 17;221(1):145-55. DOI:10.1530/JOE-13-0306
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