ChemicalBook > CAS DataBase List > L-Homocystine

L-Homocystine

Product Name: L-Homocystine
CAS No.: 626-72-2
Chemical Name: L-Homocystine
Synonyms: (2S,2'S)-4,4'-Disulfanediylbis(2-aMinobutanoic acid);H-HoCys-OH;(H-HCY-OH)2;(H-Hcy-OH)?;H-L-HCystine;(H-HOCYS-OH)2;H-L-HOCYSTINE;(H-Hcys-OH) 2;L-Homocystine;(H-HOMOCYS-OH)2
CBNumber: CB5155903
Molecular Formula: C8H16N2O4S2
Formula Weight: 268.35
MOL File: 626-72-2.mol

Less

L-Homocystine Property

Melting point:: 281-284 °C (dec.)(lit.)
alpha: 77 º (c=1% in 1N HCl)
Boiling point:: 507.6±50.0 °C(Predicted)
Density: 1.443±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: H2O : 5 mg/mL (18.63 mM; ultrasonic and adjust pH to 3 with H2O)DMSO : 1 mg/mL (3.73 mM; ultrasonic and adjust pH to 5 with HCl)
form: Powder
pka: 1.90±0.10(Predicted)
color: Off-white to light yellow
optical activity: 73.7°(C=0.97g/100ml 1N HCL)
BRN: 1728583
InChI: InChI=1S/C8H16N2O4S2/c9-5(7(11)12)1-3-15-16-4-2-6(10)8(13)14/h5-6H,1-4,9-10H2,(H,11,12)(H,13,14)/t5-,6-/m0/s1
InChIKey: ZTVZLYBCZNMWCF-WDSKDSINSA-N
SMILES: S(CC[C@H](N)C(O)=O)SCC[C@H](N)C(O)=O
CAS DataBase Reference: 626-72-2(CAS DataBase Reference)
EPA Substance Registry System: L-Homocystine (626-72-2)

Less

Safety

Safety Statements: 22-24/25
WGK Germany: 3
HS Code: 29309090

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: H6010
Product name: L-Homocystine
Purity: ≥98% (HPLC)
Packaging: 100mg
Price: $129
Updated: 2025/07/31

Sigma-Aldrich

Product number: H6010
Product name: L-Homocystine
Purity: ≥98% (HPLC)
Packaging: 1g
Price: $583.77
Updated: 2025/07/31

Sigma-Aldrich

Product number: H6010
Product name: L-Homocystine
Purity: ≥98% (HPLC)
Packaging: 500mg
Price: $371
Updated: 2025/07/31

TRC

Product number: H591360
Product name: L-Homocystine
Packaging: 10g
Price: $145
Updated: 2021/12/16

Usbiological

Product number: H7000
Product name: L-Homocystine, 99%
Packaging: 1g
Price: $330
Updated: 2021/12/16

Less

L-Homocystine Chemical Properties,Usage,Production

Chemical Properties

L-homocysteine is an aliphatic amino acid with the molecular formula (C8H16N2O4S2). It is a white powder with an acidic taste and is easily soluble in water. It has limited solubility in ethanol. L-homocysteine has a sulfhydryl group on its side chain, which allows it to form disulfide bonds with other L-homocysteine residues in proteins. This feature contributes to the stable three-dimensional structure of proteins. As a result, L-homocysteine finds extensive applications in industries such as pharmaceuticals, food, feed, and cosmetics.

Uses

Increased levels lead to hyperhomocysteinemia; a cardiovascular risk factor in prediction of coronary heart disease as well as being associated with congenital birth defects, pregnancy complications and cancer.

Definition

ChEBI: L,L-homocystine is a homocystine in which both chiral centres have L configuration. It is functionally related to a L-homocysteine. It is a tautomer of a L,L-homocystine zwitterion.

Biological Activity

L-Homocystine is the oxidized member of the L-homocysteine:L-homocystine pair. Homocysteine/homocystine is derived from methionine. Homocysteine is a pro-thrombotic factor, vasodilation impairing agent, pro-inflammatory factor and endoplasmatic reticulum-stress inducer used to study cardiovascular disease mechanisms.

Synthesis

L-homoserine(626-72-2) is biosynthesized from L-aspartate, which is synthesized from oxaloacetate, a TCA cycle intermediate. Homoserine is activated through esterification to form the O-acetyl ester by the enzyme homoserine O-acetyltransferase. In certain organisms, including the yeast Saccharomyces cerevisiae and certain bacteria, hydrogen sulfide reacts with O-acetyl-L-homoserine, replacing the acetyl group and forming L-homocysteine.

Purification Methods

The acid (3g) is dissolved in freshly boiled H2O (30mL) under N2, cooled under N2 (all operations should be under N2), absolute EtOH (100mL) is added, the acid is filtered off, and a second crop is obtained by diluting the filtrate to 500mL with absolute EtOH, kept overnight in a refrigerator, filtered, washed with EtOH and dried in a vacuum. The D(R,R)-form has similar properties but is –ve in M HCl and +ve in H2O. [du Vigneaud & Patterson J Biol Chem 109 101 1935, du Vigneaud & Brown Biochemical Preparations 5 93, 95 1975, Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 pp 2667-2670 1961, Beilstein 4 III 1643, 4 IV 3199, Koegel et al. J Am Chem Soc 77 5708 1955.]

L-Homocystine Preparation Products And Raw materials

Raw materials

Preparation Products

Less

L-Homocystine Suppliers

Canada 1 China 206 Germany 5 India 4 Japan 2 Switzerland 4 The Netherlands 2 United Kingdom 4 United States 31 Global 259

Nanjing Derno Pharmaceutical Technology Co., Ltd.

Tel: 025-86957866 13952093866
Fax: 025-68661287
Email: sales@dernopharm.com
Country: China
ProdList: 932
Advantage: 58

Jia Xing Isenchem Co.,Ltd

Tel: 0573-85285100 18627885956
Fax: 0573-85285100
Email: isenchem@163.com
Country: China
ProdList: 9310
Advantage: 66

Xinxiang Junlong Biotechnology Co., Ltd

Tel: +86-15517316871 15517316871
Email: 1225342923@qq.com
Country: China
ProdList: 23
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: chenyj@titansci.com
Country: China
ProdList: 14101
Advantage: 59

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@163.com
Country: China
ProdList: 283
Advantage: 58

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

Shandong Xiya Chemical Co., Ltd

Tel: 4009903999 13355009207
Fax: 0539-6365991
Email: 3007715519@qq.com
Country: China
ProdList: 18729
Advantage: 57

China Langchem Inc.

Tel: 0086-21-58956006
Fax: 0086-21-58956100
Country: China
ProdList: 7811
Advantage: 57

Spectrum Chemical Manufacturing Corp.

Tel: 021-021-021-67601398-809-809-809 15221380277
Fax: 021-57711696
Email: marketing_china@spectrumchemical.com
Country: China
ProdList: 9658
Advantage: 60

Beijing HuaMeiHuLiBiological Chemical

Tel: 010-56205725
Fax: 010-65763397
Email: waley188@sohu.com
Country: China
ProdList: 12335
Advantage: 58

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-6206333 13167063860
Fax: 021-50323701
Email: anhua.mao@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

The future of Shanghai Industrial Co., Ltd.

Tel: 021-61552785
Fax: 021-55660885
Email: sales@shshiji.com
Country: China
ProdList: 9546
Advantage: 55

Guangzhou Isun Pharmaceutical Co., Ltd

Tel: 020-39119399 18927568969
Fax: 020-39119999
Email: isunpharm@qq.com
Country: China
ProdList: 4720
Advantage: 55

TargetMol Chemicals Inc.

Tel: 021-021-33632979 15002134094
Fax: 021-33632979
Email: marketing@targetmol.com
Country: China
ProdList: 7783
Advantage: 58

Shanghai BeiZhuo Biotech Co., Ltd.

Tel: 021-61119791,13386096464
Fax: 021-50190009
Email: bzswkf@foxmail.com
Country: China
ProdList: 3921
Advantage: 50

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

Sichuan Wei Keqi Biological Technology Co., Ltd.

Tel: 028-81700200 18116577057
Fax: 028-81705658
Email: 3003855609@qq.com
Country: China
ProdList: 7778
Advantage: 56

Chengdu HuaXia Chemical Reagent Co. Ltd

Tel: 400-1166-196 13458535857
Fax: QQ：800101999
Email: cdhxsj@163.com
Country: China
ProdList: 13350
Advantage: 58

Finetech Industry Limited

Tel: 027-87465837 19945049750
Fax: 027-8777-2287
Email: sales@finetechnology-ind.com
Country: China
ProdList: 9637
Advantage: 58

Hunan HuaTeng Pharmaceutical Co., Ltd.,

Tel: 400-8592883
Fax: 0731-82251112
Email: sales@huatengsci.com
Country: China
ProdList: 5872
Advantage: 58

Suzhou yacoo science co.,Ltd

Tel: 0512-87182056 18013166090
Fax: 0512-87182056
Email: lingling.qi@yacoo.com.cn
Country: China
ProdList: 6295
Advantage: 60

Shanghai YuLue Chemical Co., Ltd.

Tel: 021-60345187 13671753212
Fax: 021-34702061
Email: lzz841106@aliyun.com
Country: China
ProdList: 10263
Advantage: 55

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51395
Advantage: 80

Struchem Co., Ltd.

Tel: 0512-63009836 18994340901
Fax: 0512-63006936
Email: helen@struchem.com
Country: China
ProdList: 3981
Advantage: 60

Beijing NuoqiYa Biotechnology Co., Ltd.

Tel: 4000-819-385 010-62329685 13718666987
Fax: 010-62340519
Country: China
ProdList: 1971
Advantage: 55

Codow Chemical Co.,Ltd.

Tel: 18620099427
Fax: +86-20-62619665
Email: amy@howeipharm.com
Country: China
ProdList: 6687
Advantage: 55

Shanghai Haozhixiang Biotechnology Co., Ltd

Tel: 526763801 13301653310
Fax: +86-21-51619052
Email: 526763801@qq.com
Country: China
ProdList: 9274
Advantage: 55

Shanghai Xilong Biochemical Technology Co., Ltd.

Tel: 021-52907766-8042
Fax: 021-52906523
Country: China
ProdList: 9941
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Shanghai QianYan Bio-technology Co., Ltd

Tel: 02781293128
Email: orders@biochemsafebuy.com
Country: China
ProdList: 9923
Advantage: 55

Wuxi Asia Peptide Biotechnology Limited Company

Tel: 0510-83583050 13771062561
Fax: 0510-83583039
Email: willsun@peptide-search.com
Country: China
ProdList: 6716
Advantage: 58

Henan Jiuhua Biological Technology Co., Ltd.

Tel: 15738884691 153248764872949584887 237654463
Fax: 0371-55320919
Email: jiuhuabiochem@163.com
Country: China
ProdList: 2750
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Shanghai Uteam Biotechnology Co., Ltd.

Tel: 021-36031160 13311776681
Email: 3338195766@QQ.com
Country: China
ProdList: 5093
Advantage: 55

Shanghai Biological Technology Development Co., Ltd.

Tel: 021-69955236-807 13918189704
Fax: 021-65211385
Email: chinaruji@chinaruji.com
Country: China
ProdList: 5095
Advantage: 55

Nanjing Peptide Biotech Ltd.

Tel: 025-58361106-805 15951641583
Fax: 025-58361106-806
Email: zhao.xu@njpeptide.com
Country: China
ProdList: 9979
Advantage: 55

Amatek Scientific Co. Ltd.

Tel: 0512-56316828
Fax: 0512-56316826
Email: info@amateksci.com
Country: China
ProdList: 28785
Advantage: 58

Hangzhou Molcore Biopharmatech Co.,Ltd

Tel: 400-711-5280 86-571-81025280
Fax: 86-571-85806285
Email: sales@molcore.com
Country: China
ProdList: 9967
Advantage: 58

Jiaxing Deyi Chemical Co., Ltd.

Tel: 86-0573-85866609 13325730825
Fax: 0573-85866609
Email: 945717149@qq.com
Country: China
ProdList: 8593
Advantage: 58

Guangzhou LES biological Technology Co.,Ltd.

Tel: 13672434928
Fax: -
Email: 3307355104@qq.com
Country: China
ProdList: 3650
Advantage: 58

Shanghai Zhen Li Biological Technology Co., Ltd

Tel: 021-16621358918; 18516310516
Fax: 13045646768
Email: zhenlipharma888@163.com
Country: China
ProdList: 19035
Advantage: 58

Aikon International Limited

Tel: 025-58859352 18068836627
Fax: 02557626880
Email: sales01@aikonchem.com
Country: China
ProdList: 16027
Advantage: 58

Shanghai Haohong Pharmaceutical Co., Ltd.

Tel: 400-8210725 400821072
Fax: 021-58955996
Email: malulu@leyan.com
Country: China
ProdList: 25000
Advantage: 58

Tianjin heowns Biochemical Technology Co., Ltd.

Tel: 400-6387771-6039 18920764717
Email: sales@heowns.com
Country: China
ProdList: 23771
Advantage: 60

3A Chemicals

Tel: 400-668-9898
Fax: 010-51582189
Email: service@3achem.com
Country: China
ProdList: 20557
Advantage: 58

Zhengzhou Acme Chemical Co., Ltd.

Tel: 0371-63315541 13323832564
Fax: QQ:3001332135
Email: 3001332135@qq.com
Country: China
ProdList: 9972
Advantage: 58

Less

View Lastest Price from L-Homocystine manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: L-Homocystine 626-72-2
Price: US $2.00-5.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-07-17

WUHAN FORTUNA CHEMICAL CO., LTD

Product: L-Homocystine 626-72-2
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 5000kg/month
Release date: 2021-10-13

Henan Bao Enluo International TradeCo.，LTD

Product: L-Homocystine 626-72-2
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 500t/month
Release date: 2023-08-01

626-72-2, L-HomocystineRelated Search:

4-Aminobutyric acid D-2-Aminobutyric acid N-Acetyl-L-cysteine DL-Homocysteine L-Cystine DL-2-AMINOBUTYRIC ACID L-Cysteine Selenium sulfide DL-3-Aminobutyric acid Indole-3-butyric acid DL-2-Aminobutyric acid L(+)-2-Aminobutyric acid Cyproterone acetate 3-CARBOXYPROPYL DISULFIDE Butyl disulfide Methyl propyl disulfide r-Amino Butryric Acid ETHYL PROPYL DISULFIDE

(2S,2'S)-2,2'-Diamino-(4,4'-dithiobisbutyric acid)

3,3'-(Dithiobismethylene)bisalanine

4,4'-Dithiobis[(2S)-2-aminobutanoic acid]

4,4'-Dithiobis[(S)-2-aminobutanoic acid]

4,4'-Dithiobis[(S)-2-aminobutyric acid]

(2S,2'S)-4,4'-Disulfanediylbis(2-aMinobutanoic acid)

(2S,2'S)-4,4'-Dithiobis[2-aMinobutanoic Acid]

[S-(R*,R*)]-4,4'-Dithiobis[2-aMinobutanoic Acid]

L-Homocystine ,99%

L-Homocystine,L-4,4′-Dithiobis(2-aminobutanoic acid)

L-HOMOCYSTINE, >=98% (HPLC)

(H-L-HomoCys-OH)2

L-Homocystine≥ 99% (Assay)

H-HoCys-OH L-4,4'-Dithiobis(2-aminobutanoic acid)

(H-HCY-OH)2

(H-HOCYS-OH)2

(H-HOMOCYS-OH)2

H-L-HOCYSTINE

L-4,4'-DITHIO-BIS(2-AMINOBUTANOIC ACID)

4,4’-dithiobis[2-amino-,[s-(theta,theta)]-butanoicaci

(H-Hcy-OH)?

L-homocystine cell culture tested

[S-(R*,R*)]-4,4'-dithiobis[2-aminobutyric] acid

2-amino-4-(3-amino-3-carboxy-propyl)disulfanyl-butanoic acid

H-HoCys-OH

(H-Hcys-OH) 2

L-Homocystine

H-L-HCystine

(2S)-2-amino-4-{[(3S)-3-amino-3-carboxypropyl]disulfanyl}butanoic acid

Butanoic acid, 4,4'-dithiobis[2-amino-, (2S,2'S)-

L-Homocystine USP/EP/BP

L Homocystine,Inhibitor,Endogenous Metabolite,LHomocystine,inhibit,L-Homocystine

Vincamine Impurity 1( Vincamine EP Impurity A )

<sc>L</sc>-Homocystine

(2S)-2-Amino-4-[[(3S)-3-amino-4-hydroxy-4-oxo-butyl]disulfanyl]butanoic acid

626-72-2

C8H16N2O4S2

Unnatural Amino Acid Derivatives

Specialty Synthesis

Peptide Synthesis

Homo-Amino Acids

Amines

Intermediates & Fine Chemicals

Pharmaceuticals

Sulfur & Selenium Compounds

Amino Acids